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UniProtKB/Swiss-Prot entry Q8RG88

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_FUSNN
Primary accession number Q8RG88
Secondary accession numbers None
Integrated into Swiss-Prot on July 26, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 46)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: FN0420
From
Fusobacterium nucleatum subsp. nucleatum [TaxID: 76856] [HAMAP proteome]
Taxonomy Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Fusobacterium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25586 / CIP 101130 / JCM 8532 / LMG 13131;
DOI=10.1128/JB.184.7.2005-2018.2002; PubMed=11889109 [NCBI, ExPASy, EBI, Israel, Japan]
Kapatral V., Anderson I., Ivanova N., Reznik G., Los T., Lykidis A., Bhattacharyya A., Bartman A., Gardner W., Grechkin G., Zhu L., Vasieva O., Chu L., Kogan Y., Chaga O., Goltsman E., Bernal A., Larsen N., D'Souza M., Walunas T., Pusch G., Haselkorn R., Fonstein M., Kyrpides N.C., Overbeek R.;
"Genome sequence and analysis of the oral bacterium Fusobacterium nucleatum strain ATCC 25586.";
J. Bacteriol. 184:2005-2018(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009951; AAL94623.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_603324.1; -.
3D structure databases
ModBase Q8RG88.
Enzyme and pathway databases
BioCyc FNUC190304:FN0420-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
BLOCKS Q8RG88.
Genome annotation databases
GeneID 992862; -.
GenomeReviews AE009951_GR; FN0420.
KEGG fnu:FN0420; -.
NMPDR fig|190304.1.peg.1003; -.
Phylogenomic databases
HOGENOM Q8RG88; -.
Genome annotation databases
CMR Q8RG88; FN0420.
Other
ProtoNet Q8RG88.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   425  425     Dihydroorotase. PRO_0000147234
METAL   56    56        Zinc 1 (By similarity). 
METAL   58    58        Zinc 1 (By similarity). 
METAL   174   174        Zinc 2 (By similarity). 
METAL   227   227        Zinc 2 (By similarity). 
METAL   300   300        Zinc 1 (By similarity). 
Sequence information
Length: 425 AA [This is the length of the unprocessed precursor] Molecular weight: 47382 Da [This is the MW of the unprocessed precursor] CRC64: 1AA264FD8179C981 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLLKNCKILK NTKFEKVDIL IRDNKIEKIS ENIDITDENI IDIKNRFVTA GFIDVHVHWR 

        70         80         90        100        110        120 
EPGFSKKETV YTASRAAARG GFTTVMTMPN LNPVPDSVET LNKQLEIIKK DSVIRAIPYG 

       130        140        150        160        170        180 
AITKEEYGRE LSDMEAIASN VFAFTDDGRG VQSANVMYEA MLMGAKLNKA IVAHCEDNSL 

       190        200        210        220        230        240 
IRGGAMHEGK RSAELGIKGI PSICESTQIV RDVLLAEAAN CHYHVCHISA KESVRAVREG 

       250        260        270        280        290        300 
KKNGIKVTCE VTPHHLLSCD EDIKEDNGMW KMNPPLRSRE DRNALIVGIL DGTIDIIATD 

       310        320        330        340        350        360 
HAPHTMEEKI RGIEKSSFGI VGSETAFAQL YTKFVKTDIF SLEMLVKLMS ENVAKIFDLP 

       370        380        390        400        410        420 
YGKLEENSFA DIVVIDLEKE ITINPNNFLS KGKNTPYINE KINGIPVLTI SNGKIAYIDK 


EEINL
Q8RG88 in FASTA format

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