[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY. PubMed=11432789 [NCBI, ExPASy, EBI, Israel, Japan] Aoki N., Aoyama K., Nagata M., Matsuda T.; "A growing family of dual specificity phosphatases with low molecular masses."; J. Biochem. 130:133-140(2001).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=C57BL/6J; The mouse genome sequencing consortium; Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). TISSUE=Brain; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[4]	NUCLEOTIDE SEQUENCE [MRNA] OF 1-125 (ISOFORM 1). DOI=10.1093/nar/29.24.4983; PubMed=11812828 [NCBI, ExPASy, EBI, Israel, Japan] Mu X., Zhao S., Pershad R., Hsieh T.-F., Scarpa A., Wang S.W., White R.A., Beremand P.D., Thomas T.L., Gan L., Klein W.H.; "Gene expression in the developing mouse retina by EST sequencing and microarray analysis."; Nucleic Acids Res. 29:4983-4993(2001).

Comments

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.
CATALYTIC ACTIVITY: A phosphoprotein + H₂O = a protein + phosphate.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	Q8R4V2-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q8R4V2-2
Note: Inactive. Lacks the active site.
Features which should be applied to build the isoform sequence: VSP_007294, VSP_007295.

TISSUE SPECIFICITY: Isoform 2 is highly expressed in testis.
SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
SEQUENCE CAUTION:
- Sequence=BU924460; Type=Frameshift; Positions=120;

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AF357887; AAM00226.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AL833801; CAM23680.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC116841; AAI16842.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC116843; AAI16844.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BU924460; -; NOT_ANNOTATED_CDS; mRNA.	[EMBL / GenBank / DDBJ]

UniGene

Mm.330671

3D structure databases

HSSP

P51452; 1VHR. [HSSP ENTRY / PDB]

SMR

Q8R4V2; 1-125.

ModBase

Q8R4V2.

Organism-specific databases

MGI

MGI:1934928; Dusp15.

Gene expression databases

ArrayExpress

Q8R4V2; -.

CleanEx

MM_DUSP15; -.

GermOnline

ENSMUSG00000042662; Mus musculus.

Ontologies

GO:0004725;	Molecular function: protein tyrosine phosphatase activity (inferred from electronic annotation from InterPro).
GO:0016311;	Biological process: dephosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000387; Tyr_Pase.
IPR016130; Tyr_Pase_AS.
IPR000340; Tyr_Pase_dual_specific.
Graphical view of domain structure.

Pfam

PF00782; DSPc; 1.
Pfam graphical view of domain structure.

SMART

SM00195; DSPc; 1.
SMART graphical view of domain structure.

PROSITE

PS00383; TYR_PHOSPHATASE_1; 1.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

Q8R4V2.

Genome annotation databases

Ensembl

ENSMUSG00000042662; Mus musculus. [Contig view]

Phylogenomic databases

HOGENOM

Q8R4V2; -.

HOVERGEN

Q8R4V2; -.

Other

SOURCE

Dusp15; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Hydrolase; Protein phosphatase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 235`	`235`	`Dual specificity protein phosphatase 15.`	`PRO_0000094825`
`DOMAIN`	`65 135`	`71`	`Tyrosine-protein phosphatase.`
`ACT_SITE`	`88 88`		`Phosphocysteine intermediate (By similarity).`
`VAR_SEQ`	`88 105`		`CFAGISRSTTIVIAYVMT -> WPLKHECRARSLSLLQCS (in isoform 2).`	`VSP_007294`
`VAR_SEQ`	`106 235`		`Missing (in isoform 2).`	`VSP_007295`

Sequence information

Length: 235 AA [This is the length of the unprocessed precursor]

Molecular weight: 26186 Da [This is the MW of the unprocessed precursor]

CRC64: 09A3EB05A0A7F891 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGNGMTKVLP GLYLGNFIDA KDPDQLGRNK ITHIISIHES PQPLLQDITY LRISVSDTPE 

        70         80         90        100        110        120 
VPIKKHFKEC VHFIHSCRLN GGNCLVHCFA GISRSTTIVI AYVMTVTGLG WQEVLEAIKA 

       130        140        150        160        170        180 
SRPIANPNPG FRQQLEEFGW ANSQKLRRQL EERFGEIPFR DEEDLRALLP LCRRCRQGSA 

       190        200        210        220        230 
TSAASATTAS SAAEGTLQRL VPRSPRDSHQ PLPLLARVKQ TFFCLPRCLS RKGGK

Q8R4V2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools