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UniProtKB/Swiss-Prot entry Q8R429

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT2A1_MOUSE
Primary accession number Q8R429
Secondary accession numbers None
Integrated into Swiss-Prot on May 24, 2005
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 58)
Name and origin of the protein
Protein name Sarcoplasmic/endoplasmic reticulum calcium ATPase 1
Synonyms SERCA1
EC 3.6.3.8
Calcium pump 1
Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform
SR Ca(2+)-ATPase 1
Endoplasmic reticulum class 1/2 Ca(2+) ATPase
Gene name
Name: Atp2a1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c X CD-1;
TISSUE=Skeletal muscle;
Kraev A.;
"Towards a complete inventory of calcium transporters of the house mouse.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Salivary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AY081946; AAL87408.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC036292; AAH36292.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_031530.2; -.
UniGene Mm.35134
3D structure databases
HSSP P04191; 1SU4. [HSSP ENTRY / PDB]
SMR Q8R429; 1-994.
ModBase Q8R429.
PTM databases
PhosphoSite Q8R429; -.
Organism-specific databases
MGI MGI:105058; Atp2a1.
Gene expression databases
ArrayExpress Q8R429; -.
GermOnline ENSMUSG00000030730; Mus musculus.
Ontologies
GO
GO:0005793; Cellular component: ER-Golgi intermediate compartment (inferred from sequence or structural similarity from UniProtKB).
GO:0031673; Cellular component: H zone (inferred from sequence or structural similarity from UniProtKB).
GO:0031674; Cellular component: I band (inferred from sequence or structural similarity from UniProtKB).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0048471; Cellular component: perinuclear region of cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0033017; Cellular component: sarcoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0005524; Molecular function: ATP binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005509; Molecular function: calcium ion binding (inferred from sequence or structural similarity from UniProtKB).
GO:0005388; Molecular function: calcium-transporting ATPase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from sequence or structural similarity from UniProtKB).
GO:0006200; Biological process: ATP catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006816; Biological process: calcium ion transport (inferred from sequence or structural similarity from UniProtKB).
GO:0045988; Biological process: negative regulation of striated muscle contraction (inferred from sequence or structural similarity from UniProtKB).
GO:0031448; Biological process: positive regulation of fast-twitch skeletal muscle fiber contraction (inferred from sequence or structural similarity from UniProtKB).
GO:0015992; Biological process: proton transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR006068; ATPase_P_cat_C.
IPR004014; ATPase_P_cat_N.
IPR005782; Calcium_ATPase.
IPR005834; Dehalogen-like_hydro.
IPR008250; E1-E2_ATPase_reg.
IPR000695; H_ATPase.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
Pfam PF00689; Cation_ATPase_C; 1.
PF00690; Cation_ATPase_N; 1.
PF00122; E1-E2_ATPase; 1.
PF00702; Hydrolase; 1.
Pfam graphical view of domain structure.
PRINTS PR00119; CATATPASE.
PR00120; HATPASE.
TIGRFAMs TIGR01116; ATPase-IIA1_Ca; 1.
TIGR01494; ATPase_P-type; 4.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet Q8R429.
Genome annotation databases
Ensembl ENSMUSG00000030730; Mus musculus. [Contig view]
GeneID 11937; -.
KEGG mmu:11937; -.
NMPDR fig|10090.3.peg.17619; -.
Phylogenomic databases
HOGENOM Q8R429; -.
HOVERGEN Q8R429; -.
Other
NextBio 280035; -.
SOURCE Atp2a1; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Calcium; Calcium transport; Endoplasmic reticulum; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Sarcoplasmic reticulum; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   994  994     Sarcoplasmic/endoplasmic reticulum calcium ATPase 1. PRO_0000046188
TOPO_DOM   1    48  48     Cytoplasmic (By similarity). 
TRANSMEM   49    69  21     1 (By similarity). 
TOPO_DOM   70    89  20     Lumenal (By similarity). 
TRANSMEM   90   110  21     2 (By similarity). 
TOPO_DOM   111   253  143     Cytoplasmic (By similarity). 
TRANSMEM   254   273  20     3 (By similarity). 
TOPO_DOM   274   295  22     Lumenal (By similarity). 
TRANSMEM   296   313  18     4 (By similarity). 
TOPO_DOM   314   757  444     Cytoplasmic (By similarity). 
TRANSMEM   758   777  20     5 (By similarity). 
TOPO_DOM   778   787  10     Lumenal (By similarity). 
TRANSMEM   788   808  21     6 (By similarity). 
TOPO_DOM   809   828  20     Cytoplasmic (By similarity). 
TRANSMEM   829   851  23     7 (By similarity). 
TOPO_DOM   852   897  46     Lumenal (By similarity). 
TRANSMEM   898   917  20     8 (By similarity). 
TOPO_DOM   918   930  13     Cytoplasmic (By similarity). 
TRANSMEM   931   949  19     9 (By similarity). 
TOPO_DOM   950   964  15     Lumenal (By similarity). 
TRANSMEM   965   985  21     10 (By similarity). 
TOPO_DOM   986   994  9     Cytoplasmic (By similarity). 
REGION   370   400  31     Interacts with phospholamban 1 (By similarity). 
REGION   788   808  21     Interacts with phospholamban 2 (By similarity). 
ACT_SITE   351   351        4-aspartylphosphate intermediate (By similarity). 
METAL   304   304        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   305   305        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   307   307        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   309   309        Calcium 2 (By similarity). 
METAL   703   703        Magnesium (By similarity). 
METAL   707   707        Magnesium (By similarity). 
METAL   768   768        Calcium 1 (By similarity). 
METAL   771   771        Calcium 1 (By similarity). 
METAL   796   796        Calcium 2 (By similarity). 
METAL   799   799        Calcium 1 (By similarity). 
METAL   800   800        Calcium 1 (By similarity). 
METAL   800   800        Calcium 2 (By similarity). 
METAL   908   908        Calcium 1 (By similarity). 
DISULFID   876   888        By similarity. 
Sequence information
Length: 994 AA [This is the length of the unprocessed precursor] Molecular weight: 109425 Da [This is the MW of the unprocessed precursor] CRC64: 884FBDD286B4916B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MEAAHSKSTE ECLSYFGVSE TTGLTPDQVK RHLEKYGPNE LPAEEGKSLW ELVVEQFEDL 

        70         80         90        100        110        120 
LVRILLLAAC ISFVLAWFEE GEETVTAFVE PFVILLILIA NAIVGVWQER NAENAIEALK 

       130        140        150        160        170        180 
EYEPEMGKVY RADRKSVQRI KARDIVPGDI VEVAVGDKVP ADIRILSIKS TTLRVDQSIL 

       190        200        210        220        230        240 
TGESVSVIKH TDPVPDPRAV NQDKKNMLFS GTNIAAGKAV GIVATTGVST EIGKIRDQMA 

       250        260        270        280        290        300 
ATEQDKTPLQ QKLDEFGEQL SKVISLICVA VWLINIGHFN DPVHGGSWFR GAIYYFKIAV 

       310        320        330        340        350        360 
ALAVAAIPEG LPAVITTCLA LGTRRMAKKN AIVRSLPSVE TLGCTSVICS DKTGTLTTNQ 

       370        380        390        400        410        420 
MSVCKMFIID KVDGDVCSLN EFSITGSTYA PEGEVLKNDK PVRAGQYDGL VELATICALC 

       430        440        450        460        470        480 
NDSSLDFNET KGVYEKVGEA TETALTTLVE KMNVFNTEVR SLSKVERANA CNSVIRQLMK 

       490        500        510        520        530        540 
KEFTLEFSRD RKSMSVYCSP AKSSRAAVGN KMFVKGAPEG VIDRCNYVRV GTTRVPLTGP 

       550        560        570        580        590        600 
VKEKIMSVIK EWGTGRDTLR CLALATRDTP PKREEMVLDD SAKFMEYEMD LTFVGVVGML 

       610        620        630        640        650        660 
DPPRKEVTGS IQLCRDAGIR VIMITGDNKG TAIAICRRIG IFSENEEVTD RAYTGREFDD 

       670        680        690        700        710        720 
LPLAEQREAC RRACCFARVE PSHKSKIVEY LQSYDEITAM TGDGVNDAPA LKKAEIGIAM 

       730        740        750        760        770        780 
GSGTAVAKTA SEMVLADDNF STIVAAVEEG RAIYNNMKQF IRYLISSNVG EVVCIFLTAA 

       790        800        810        820        830        840 
LGLPEALIPV QLLWVNLVTD GLPATALGFN PPDLDIMDRP PRSPKEPLIS GWLFFRYMAI 

       850        860        870        880        890        900 
GGYVGAATVG AAAWWFLYAE DGPHVSYHQL THFMQCTEHN PEFDGLDCEV FEAPEPMTMA 

       910        920        930        940        950        960 
LSVLVTIEMC NALNSLSENQ SLLRMPPWVN IWLLGSICLS MSLHFLILYV DPLPMIFKLR 

       970        980        990 
ALDFTQWLMV LKISLPVIGL DELLKFIARN YLEG
Q8R429 in FASTA format

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