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UniProtKB/Swiss-Prot entry Q8R2U6


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NUDT4_MOUSE
Primary accession number Q8R2U6
Secondary accession numbers Q8BXB9 Q9D3T6
Integrated into Swiss-Prot on July 5, 2005
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Diphosphoinositol polyphosphate phosphohydrolase 2
Synonyms DIPP-2
EC 3.6.1.52
Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 2
EC 3.6.1.-
Nucleoside diphosphate-linked moiety X motif 4
Nudix motif 4
Gene name
Name: Nudt4
Synonyms: Dipp2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Head, and Testis;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
X-RAY CRYSTALLOGRAPHY (2.62 ANGSTROMS) OF 8-145.
RIKEN structural genomics initiative (RSGI);
"Crystal structure of MS0616.";
Submitted (JAN-2007) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK017075; BAB30582.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK048062; BAC33229.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC027209; AAH27209.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_081998.3; -.
UniGene Mm.24397
3D structure databases
PDB
2DUK; X-ray; 2.62 A; A/B=8-145.[ExPASy / RCSB / EBI]
PDBsum 2DUK; -.
SMR Q8R2U6; 8-145.
ModBase Q8R2U6.
Organism-specific databases
MGI MGI:1918457; Nudt4.
Gene expression databases
ArrayExpress Q8R2U6; -.
GermOnline ENSMUSG00000020029; Mus musculus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0008486; Molecular function: diphosphoinositol-polyphosphate diphosphatase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030145; Molecular function: manganese ion binding (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000086; NUDIX_hydrolase_core.
Graphical view of domain structure.
Gene3D G3DSA:3.90.79.10; NUDIX_hydrolase; 1.
Pfam PF00293; NUDIX; 1.
Pfam graphical view of domain structure.
PRINTS PR00502; NUDIXFAMILY.
PROSITE PS00893; NUDIX; 1.
ProtoNet Q8R2U6.
Genome annotation databases
Ensembl ENSMUSG00000020029; Mus musculus. [Contig view]
GeneID 71207; -.
KEGG mmu:71207; -.
Phylogenomic databases
HOGENOM Q8R2U6; -.
HOVERGEN Q8R2U6; -.
Other
NextBio 333289; -.
SOURCE Nudt4; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Cytoplasm; Hydrolase; Magnesium; Manganese; Metal-binding.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   179  179     Diphosphoinositol polyphosphate phosphohydrolase 2. PRO_0000057059
MOTIF   50    71  22     Nudix box. 
METAL   65    65        Magnesium or manganese (By similarity). 
METAL   69    69        Magnesium or manganese (By similarity). 
CONFLICT   69    69        E -> Q (in Ref. 1; BAC33229). 
CONFLICT   168   168        A -> C (in Ref. 1; BAB30582). 
Sequence information
Length: 179 AA [This is the length of the unprocessed precursor] Molecular weight: 20156 Da [This is the MW of the unprocessed precursor] CRC64: 05A78EBBA8256B89 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKFKPNQTRT YDREGFKKRA ACLCFRSEQE DEVLLVSSSR YPDQWIVPGG GMEPEEEPGG 

        70         80         90        100        110        120 
AAVREVYEEA GVKGKLGRLL GIFENQDRKH RTYVYVLTVT EILEDWEDSV NIGRKREWFK 

       130        140        150        160        170 
VEDAIKVLQC HKPVHAEYLE KLKLGCSPTN GNSSVPSLPD NNALFVTAAP PSGVPSSIR 

Q8R2U6 in FASTA format

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