CATALYTIC ACTIVITY: NAD⁺ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.
CATALYTIC ACTIVITY: NADP⁺ + protein-L-arginine = nicotinamide + N(omega)-((2'-phospho-ADP)-D-ribosyl)-protein-L-arginine.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).

ALTERNATIVE PRODUCTS: 6 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	Q8R2G4-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	Q8R2G4-2
Features which should be applied to build the isoform sequence: VSP_003376, VSP_003377.

Name	3
Isoform ID	Q8R2G4-3
Features which should be applied to build the isoform sequence: VSP_003377.

Name	4
Isoform ID	Q8R2G4-4
Features which should be applied to build the isoform sequence: VSP_003376, VSP_003378.

Name	5
Isoform ID	Q8R2G4-5
Features which should be applied to build the isoform sequence: VSP_003379.

Name	6
Isoform ID	Q8R2G4-6
Features which should be applied to build the isoform sequence: VSP_003376.

PTM: Contains two disulfide bonds (By similarity).
SIMILARITY: Belongs to the Arg-specific ADP-ribosyltransferase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ311768; CAC84539.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ311769; CAC84526.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ311770; CAC84540.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ311771; CAC84541.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ311772; CAC84542.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ311773; CAC84543.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_859417.2; -.

UniGene

Mm.263514

3D structure databases

HSSP

P20974; 1GXY. [HSSP ENTRY / PDB]

ModBase

Q8R2G4.

Organism-specific databases

MGI

MGI:1202729; Art3.

Gene expression databases

CleanEx

MM_ART3; -.

GermOnline

ENSMUSG00000034842; Mus musculus.

Ontologies

GO:0031225;	Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0003956;	Molecular function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity (inferred from electronic annotation from InterPro).
GO:0006471;	Biological process: protein amino acid ADP-ribosylation (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR000768; ART.
Graphical view of domain structure.

PANTHER

PTHR10339; ART; 1.

Pfam

PF01129; ART; 1.
Pfam graphical view of domain structure.

PRINTS

PR00970; RIBTRNSFRASE.

ProtoNet

Q8R2G4.

Genome annotation databases

Ensembl

ENSMUSG00000034842; Mus musculus. [Contig view]

GeneID

109979; -.

KEGG

mmu:109979; -.

Phylogenomic databases

HOGENOM

Q8R2G4; -.

HOVERGEN

Q8R2G4; -.

Other

NextBio

363113; -.

SOURCE

Art3; Mus musculus.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Cell membrane; Glycoprotein; Glycosyltransferase; GPI-anchor; Lipoprotein; Membrane; NAD; NADP; Signal; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 26`	`26`	`Potential.`
`CHAIN`	`27 381`	`355`	`Ecto-ADP-ribosyltransferase 3.`	`PRO_0000019327`
`PROPEP`	`382 420`	`39`	`Removed in mature form (By similarity).`	`PRO_0000019328`
`ACT_SITE`	`228 228`		`By similarity.`
`LIPID`	`381 381`		`GPI-anchor amidated serine (By similarity).`
`CARBOHYD`	`182 182`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`247 247`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`355 355`		`N-linked (GlcNAc...) (Potential).`
`VAR_SEQ`	`271 420`		`EYIDPRYLYNPGEYTLLQTTQIWTIRSLKTLVPGIKPWAP` `CKLVGTTLTLTECQKLKCYKQRKILSCRMKSLTEVEERPT` `ILVRNTSFSLKNALKYKTVKLILFFIKSSRSGSRSEIPSL` `CILWQYAPSISHGIHHFTRCFCCKLHRAIA -> GRNNLDPDRMPEIKVLQTEENPLLPDEKPDRSRGKANNPT` `PGLVPGPKSHPSASSGNTLLPSVMASTILLVASAVNFIEL (in isoform 5).`	`VSP_003379`
`VAR_SEQ`	`303 314`		`Missing (in isoform 2, isoform 4 and isoform 6).`	`VSP_003376`
`VAR_SEQ`	`343 420`		`TEVEERPTILVRNTSFSLKNALKYKTVKLILFFIKSSRSG` `SRSEIPSLCILWQYAPSISHGIHHFTRCFCCKLHRAIA -> LQVWFQVRNPIPLHPLAIRSFHQSWHPPFYSLLLL (in isoform 2 and isoform 3).`	`VSP_003377`
`VAR_SEQ`	`353 420`		`VRNTSFSLKNALKYKTVKLILFFIKSSRSGSRSEIPSLCI` `LWQYAPSISHGIHHFTRCFCCKLHRAIA -> LQVWFQVRNPIPLHPLAIRSFHQSWHPPFYSLLLL (in isoform 4).`	`VSP_003378`

Sequence information

Length: 420 AA [This is the length of the unprocessed precursor]

Molecular weight: 48302 Da [This is the MW of the unprocessed precursor]

CRC64: DA013A5718DC2FD7 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKMGHFEMVT TLLAAAVLMD IFQVKAEVLD MAENAFDDEY LKCKSRMESK YIPQMKREEW 

        70         80         90        100        110        120 
ANDALLRMVW DNAEIQWEAR KAQLFLPRNF KDTYGIALTA YVNEAQEQTS FYHTFSSAVK 

       130        140        150        160        170        180 
MAGLSRRRYI YNFPFKAFHF YLVRALQLLR RPCEKSYKTV VYSTSPDISF TFGEQNQARL 

       190        200        210        220        230        240 
GNFTLAYSAK PETADNQRVL TIQTCFGVAV GKFLNKEDDS VVLIPLSEVF QVSRKGTSND 

       250        260        270        280        290        300 
LVLQSINSTC SYYECAFLGG LKTENCIANA EYIDPRYLYN PGEYTLLQTT QIWTIRSLKT 

       310        320        330        340        350        360 
LVPGIKPWAP CKLVGTTLTL TECQKLKCYK QRKILSCRMK SLTEVEERPT ILVRNTSFSL 

       370        380        390        400        410        420 
KNALKYKTVK LILFFIKSSR SGSRSEIPSL CILWQYAPSI SHGIHHFTRC FCCKLHRAIA

Q8R2G4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools