ID   GRP_MOUSE               Reviewed;         146 AA.
AC   Q8R1I2; Q3UTL2;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   22-JUL-2008, entry version 39.
DE   RecName: Full=Gastrin-releasing peptide;
DE            Short=GRP;
DE   Contains:
DE     RecName: Full=Neuromedin-C;
DE     AltName: Full=GRP-10;
DE   Flags: Precursor;
GN   Name=Grp;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY, AND FUNCTION IN CONTROL OF FEAR.
RX   MEDLINE=22414812; PubMed=12526815; DOI=10.1016/S0092-8674(02)01116-9;
RA   Shumyatsky G.P., Tsvetkov E., Malleret G., Vronskaya S., Hatton M.,
RA   Hampton L., Battey J.F., Dulac C., Kandel E.R., Bolshakov V.Y.;
RT   "Identification of a signaling network in lateral nucleus of amygdala
RT   important for inhibiting memory specifically related to learned
RT   fear.";
RL   Cell 111:905-918(2002).
CC   -!- FUNCTION: GRP stimulates gastrin release as well as other
CC       gastrointestinal hormones. Operates as a negative feedback
CC       regulating fear and established a causal relationship between GRP-
CC       receptor gene expression, long-term potentiation, and amygdala-
CC       dependent memory for fear.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Highly expressed both in the lateral nucleus
CC       of the amygdala, and in regions sending synaptic projections to
CC       the lateral nucleus.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin
CC       family.
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DR   EMBL; AK133508; BAE21694.1; -; mRNA.
DR   EMBL; AK139345; BAE23968.1; -; mRNA.
DR   EMBL; BC024515; AAH24515.1; -; mRNA.
DR   RefSeq; NP_778177.1; -.
DR   UniGene; Mm.20298; -.
DR   Ensembl; ENSMUSG00000024517; Mus musculus.
DR   GeneID; 225642; -.
DR   KEGG; mmu:225642; -.
DR   MGI; MGI:95833; Grp.
DR   HOVERGEN; Q8R1I2; -.
DR   ArrayExpress; Q8R1I2; -.
DR   CleanEx; MM_GRP; -.
DR   GermOnline; ENSMUSG00000024517; Mus musculus.
DR   InterPro; IPR000874; Bombesin.
DR   InterPro; IPR015674; Gastrin-RP.
DR   PANTHER; PTHR16866; Gastrin-RP; 1.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Secreted; Signal.
FT   SIGNAL        1     23       By similarity.
FT   PEPTIDE      24     52       Gastrin-releasing peptide.
FT                                /FTId=PRO_0000262472.
FT   PEPTIDE      43     52       Neuromedin-C.
FT                                /FTId=PRO_0000262473.
FT   PROPEP       56    146       By similarity.
FT                                /FTId=PRO_0000262474.
FT   MOD_RES      52     52       Methionine amide (By similarity).
FT   CONFLICT    134    134       L -> Q (in Ref. 1; BAE23968).
SQ   SEQUENCE   146 AA;  15659 MW;  83FD03C40E670CA5 CRC64;
     MRGSELSLLL LALVLCQAPR GPAAPVSTGA GGGTVLAKMY PRGSHWAVGH LMGKKSTDES
     PSLYAADRDG LKEQLRGYVR WEEAARDLLD LLEAAGNQSH QPPQHPPLSL QPTWDPEDGS
     YFNDVQTAKL VDSLLQVLKE KGGTAS
//