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UniProtKB/Swiss-Prot entry Q8R127


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SCPDH_MOUSE
Primary accession number Q8R127
Secondary accession number Q3TMB9
Integrated into Swiss-Prot on August 30, 2005
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name Probable saccharopine dehydrogenase
Synonym EC 1.5.1.9
Gene name
Name: Sccpdh
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Cerebellum, Corpora quadrigemina, and Lung;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK042919; BAC31405.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK046033; BAC32578.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK077695; BAC36962.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK082803; BAC38628.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK166018; BAE38523.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC025803; AAH25803.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_848768.1; -.
UniGene Mm.136458
3D structure databases
ModBase Q8R127.
Organism-specific databases
MGI MGI:1924486; Sccpdh.
Gene expression databases
ArrayExpress Q8R127; -.
CleanEx MM_SCCPDH; -.
GermOnline ENSMUSG00000038936; Mus musculus.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0047131; Molecular function: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity (inferred from electronic annotation from EC).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR005097; Saccharopine_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF03435; Saccharop_dh; 1.
Pfam graphical view of domain structure.
ProtoNet Q8R127.
Genome annotation databases
Ensembl ENSMUSG00000038936; Mus musculus. [Contig view]
GeneID 109232; -.
KEGG mmu:109232; -.
Phylogenomic databases
HOGENOM Q8R127; -.
HOVERGEN Q8R127; -.
Other
NextBio 361807; -.
SOURCE Sccpdh; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   429  429     Probable saccharopine dehydrogenase. PRO_0000212841
Sequence information
Length: 429 AA [This is the length of the unprocessed precursor] Molecular weight: 47129 Da [This is the MW of the unprocessed precursor] CRC64: FCC63118BFCEE7E4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MATEQRPFHL VVFGASGFTG QFVTEEVARE QIASEQSSRL PWAVAGRSKE KLQQVLEKAA 

        70         80         90        100        110        120 
QKLGRPSLSS EVGVIICDIS NPASLDEMAK QAKLVLNCVG PYRFYGEPVV KACIENGTSC 

       130        140        150        160        170        180 
IDICGEPQFL ELMHAKYHEK AAEKGVYIIG SSGFDSIPAD LGVLYTRNQM NGTLTAVESF 

       190        200        210        220        230        240 
LTINTGPEGL CIHDGTWKSA IYGFGDKGSL RKLRSVSCLK PVPIVGTKLK RRWPVSYCRE 

       250        260        270        280        290        300 
LNSYSIPFLG SDISVVKRTQ RYLHENLEDS PVQYAAYVTV GGITSVIKLM FAGLFFLFFV 

       310        320        330        340        350        360 
KFSIGRQLLI KFPWLFSFGY FSKQGPTQKQ MDETSFTMTF FGQGYSHGTC VEKNKPNIRI 

       370        380        390        400        410        420 
CTQVKGPEAG YVATPIAMVQ AAMTFLSDAS DLPKGGGVFT PGAAFSRTKL IDRLNKHGIE 


FSVISSSEV 

Q8R127 in FASTA format

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View entry in raw text format (no links)
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