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UniProtKB/Swiss-Prot entry Q8R0Y6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FTHFD_MOUSE
Primary accession number Q8R0Y6
Secondary accession numbers None
Integrated into Swiss-Prot on October 25, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 64)
Name and origin of the protein
Protein name 10-formyltetrahydrofolate dehydrogenase
Synonyms 10-FTHFDH
EC 1.5.1.6
Aldehyde dehydrogenase family 1 member L1
Gene name
Name: Aldh1l1
Synonyms: Fthfd
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Liver;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC025939; AAH25939.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC028817; AAH28817.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030722; AAH30722.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030723; AAH30723.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030727; AAH30727.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC030730; AAH30730.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_081682.1; -.
UniGene Mm.30035
3D structure databases
HSSP Q28399; 1O9J. [HSSP ENTRY / PDB]
SMR Q8R0Y6; 1-307, 302-402, 405-902.
ModBase Q8R0Y6.
PTM databases
PhosphoSite Q8R0Y6; -.
Organism-specific databases
MGI MGI:1340024; Aldh1l1.
Gene expression databases
ArrayExpress Q8R0Y6; -.
CleanEx MM_ALDH1L1; -.
GermOnline ENSMUSG00000030088; Mus musculus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0048037; Molecular function: cofactor binding (inferred from electronic annotation from InterPro).
GO:0016155; Molecular function: formyltetrahydrofolate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0016742; Molecular function: hydroxymethyl-, formyl- and related transferase activity (inferred from electronic annotation from InterPro).
GO:0009258; Biological process: 10-formyltetrahydrofolate catabolic process (inferred from electronic annotation from InterPro).
GO:0009058; Biological process: biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR011407; 10_FTHF_DHase.
IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR005793; Formyl_trans_C.
IPR002376; Formyl_transf_N.
IPR001555; GART_AS.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
G3DSA:3.10.25.10; Formyl_trans_C; 1.
G3DSA:3.40.50.170; Formyl_transf_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
PF02911; Formyl_trans_C; 1.
PF00551; Formyl_trans_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036489; 10-FTHFDH; 1.
PROSITE PS50075; ACP_DOMAIN; 1.
PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PS00373; GART; 1.
PS00012; PHOSPHOPANTETHEINE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8R0Y6.
Genome annotation databases
Ensembl ENSMUSG00000030088; Mus musculus. [Contig view]
GeneID 107747; -.
KEGG mmu:107747; -.
Phylogenomic databases
HOGENOM Q8R0Y6; -.
HOVERGEN Q8R0Y6; -.
Other
NextBio 359368; -.
SOURCE Aldh1l1; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; NADP; One-carbon metabolism; Oxidoreductase; Phosphopantetheine; Phosphoprotein.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   902  902     10-formyltetrahydrofolate dehydrogenase. PRO_0000199420
DOMAIN   323   392  70     Acyl carrier. 
REGION   1   203  203     GART. 
REGION   417   902  486     Aldehyde dehydrogenase. 
ACT_SITE   106   106        Proton donor (By similarity). 
ACT_SITE   673   673        By similarity. 
ACT_SITE   707   707        By similarity. 
BINDING   354   354        Phosphopantetheine (covalent) (By similarity). 
SITE   142   142  1     Essential for catalytic activity (By similarity). 
MOD_RES   354   354        Phosphoserine (By similarity). 
Sequence information
Length: 902 AA [This is the length of the unprocessed precursor] Molecular weight: 98709 Da [This is the MW of the unprocessed precursor] CRC64: 9B5526A7FB41909E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIAVIGQSL FGQEVYCQLR KEGHEVVGVF TIPDKDGKAD PLGLEAEKDG VPVFKFPRWR 

        70         80         90        100        110        120 
ARGQALPEVV AKYQALGAEL NVLPFCSQFI PMEVINAPRH GSIIYHPSLL PRHRGASAIN 

       130        140        150        160        170        180 
WTLIHGDKKG GFTIFWADDG LDTGDLLLQK ECDVLPDDTV STLYNRFLFP EGIKGMVQAV 

       190        200        210        220        230        240 
RLIAEGTAPR RPQPEEGATY EGIQKKETAM INWDQPAEAI HNWIRGNDKV PGAWTEACGQ 

       250        260        270        280        290        300 
KLTFFNSTLN TSGLVAQGEA LPIPGAHRPG LVTKAGLILF GNDDRMLLVK NIQLEDGKMM 

       310        320        330        340        350        360 
PASQFFKGSA SSALELTEEE LATAEAVRSS WMRILPNVPE VEDSTDFFKS GAASVDVVRL 

       370        380        390        400        410        420 
VEEVKELCDG LELENEDVYM ATTFGDFIQL LVRKLRGEDG ESECVINYVE KAVKKLTLQM 

       430        440        450        460        470        480 
PYQLFIGGEF VDAEGAKTYS TINPTDGSVI CQVSLAQVSD VDKAVAAAKE AFENGLWGKI 

       490        500        510        520        530        540 
NARDRGRLLY RLADLMEQHQ EELATIEALD AGAVYTLALK THVGMSIQTF RYFAGWCDKI 

       550        560        570        580        590        600 
QGATIPINQA RPNRNLTLTK KEPVGVCGIV IPWNYPLMML SWKTAACLAA GNTVVIKPAQ 

       610        620        630        640        650        660 
VTPLTALKFA ELTLKAGIPK GVVNILPGSG SLVGQRLSDH PDVRKIGFTG STEVGKHIMK 

       670        680        690        700        710        720 
SCALSNVKKV SLELGGKSPL IIFADCDLNK AVQMGMSSVF FNKGENCIAA GRLFVEDSIH 

       730        740        750        760        770        780 
DQFVQKVVEE VGKMKIGNPL DRDTNHGPQN HEAHLRKLVE YCQRGVKEGA TLVCGGNQVP 

       790        800        810        820        830        840 
RPGFFFQPTV FTDVEDHMYI AKEESFGPIM IISRFADGDV DAVLSRANAT EFGLASGVFT 

       850        860        870        880        890        900 
RDINKALYVS DKLQAGTVFV NTYNKTDVAA PFGGFKQSGF GKDLGEAALN EYLRIKTVTF 


EY
Q8R0Y6 in FASTA format

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