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UniProtKB/Swiss-Prot entry Q8QG87


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PA21_BOTIN
Primary accession number Q8QG87
Secondary accession numbers None
Integrated into Swiss-Prot on November 28, 2002
Sequence was last modified on June 1, 2002 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 42)
Name and origin of the protein
Protein name Phospholipase A2 BITP01A [Precursor]
Synonyms EC 3.1.1.4
Phosphatidylcholine 2-acylhydrolase
BinTX-I
Gene name None
From
Bothrops insularis (Island jararaca) (Queimada jararaca) [TaxID: 8723] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Scleroglossa; Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
DOI=10.1016/S0378-1119(02)01080-6; PubMed=12459276 [NCBI, ExPASy, EBI, Israel, Japan]
Junqueira-de-Azevedo I.L.M., Ho P.L.;
"A survey of gene expression and diversity in the venom glands of the pitviper snake Bothrops insularis through the generation of expressed sequence tags (ESTs).";
Gene 299:279-291(2002).
[2]
PROTEIN SEQUENCE OF 17-138, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
TISSUE=Venom;
DOI=10.1016/j.biochi.2006.10.006; PubMed=17140721 [NCBI, ExPASy, EBI, Israel, Japan]
Cogo J.C., Lilla S., Souza G.H.M.F., Hyslop S., de Nucci G.;
"Purification, sequencing and structural analysis of two acidic phospholipases A2 from the venom of Bothrops insularis (jararaca ilhoa).";
Biochimie 88:1947-1959(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF490535; AAM09694.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P14418; 1M8R. [HSSP ENTRY / PDB]
ModBase Q8QG87.
Family and domain databases
InterPro IPR016090; Phospholipase_A2.
IPR013090; Phospholipase_A2_AS.
IPR001211; Phospholipase_A2_euk.
Graphical view of domain structure.
Gene3D G3DSA:1.20.90.10; Phospholipase_A2; 1.
PANTHER PTHR11716; Phospholipase_A2; 1.
Pfam PF00068; Phospholip_A2_1; 1.
Pfam graphical view of domain structure.
PRINTS PR00389; PHPHLIPASEA2.
ProDom PD000303; PhospholipaseA2; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00085; PA2c; 1.
SMART graphical view of domain structure.
PROSITE PS00119; PA2_ASP; 1.
PS00118; PA2_HIS; 1.
BLOCKS Q8QG87.
Phylogenomic databases
HOVERGEN Q8QG87; -.
Other
ProtoNet Q8QG87.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Direct protein sequencing; Hydrolase; Lipid degradation; Metal-binding; Secreted; Signal; Toxin.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    16  16      
CHAIN   17   138  122     Phospholipase A2 BITP01A. PRO_0000022820
ACT_SITE   63    63        By similarity. 
ACT_SITE   105   105        By similarity. 
METAL   43    43        Calcium; via carbonyl oxygen (By similarity). 
METAL   45    45        Calcium; via carbonyl oxygen (By similarity). 
METAL   47    47        Calcium; via carbonyl oxygen (By similarity). 
METAL   64    64        Calcium (By similarity). 
DISULFID   42   131        By similarity. 
DISULFID   44    60        By similarity. 
DISULFID   59   111        By similarity. 
DISULFID   65   138        By similarity. 
DISULFID   66   104        By similarity. 
DISULFID   73    97        By similarity. 
DISULFID   91   102        By similarity. 
Sequence information
Length: 138 AA [This is the length of the unprocessed precursor] Molecular weight: 15759 Da [This is the MW of the unprocessed precursor] CRC64: DFB41FD618A1CE54 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRTLWIMAVL LVGVEGNLWQ FGKMMNYVMG QSVVYKYFYY GCYCGWGGIG QPRDATDRCC 

        70         80         90        100        110        120 
FVHDCCYGKV TGCDPKTDSY TYSKENGDVV CGGDDPCKKQ ICECDRVAAT CFRDNKDTYD 

       130 
MKYWLYGAKN CQEESEPC 

Q8QG87 in FASTA format

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