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UniProtKB/Swiss-Prot entry Q8Q0T0

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HDRA_METMA
Primary accession number Q8Q0T0
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 49)
Name and origin of the protein
Protein name CoB--CoM heterodisulfide reductase 1 iron-sulfur subunit A
Synonym EC 1.8.98.1
Gene name
Name: hdrA
OrderedLocusNames: MM_0056
From
Methanosarcina mazei (Methanosarcina frisia) [TaxID: 2209] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanosarcina.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE008384; AAM29752.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_632080.1; -.
3D structure databases
HSSP P00198; 2FDN. [HSSP ENTRY / PDB]
ModBase Q8Q0T0.
Enzyme and pathway databases
BioCyc MMAZ192952:MM0056-MON; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051912; Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0015948; Biological process: methanogenesis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR006076; FAD-dep_OxRdtase.
IPR003813; FlpD.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01266; DAO; 1.
PF00037; Fer4; 3.
PF02662; FlpD; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PROSITE PS00198; 4FE4S_FER_1; 2.
PS51379; 4FE4S_FER_2; 4.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8Q0T0.
Genome annotation databases
GeneID 1478398; -.
GenomeReviews AE008384_GR; MM_0056.
KEGG mma:MM_0056; -.
NMPDR fig|192952.1.peg.56; -.
Phylogenomic databases
HOGENOM Q8Q0T0; -.
Genome annotation databases
CMR Q8Q0T0; MM_0056.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Complete proteome; FAD; Flavoprotein; Iron; Iron-sulfur; Metal-binding; Methanogenesis; Oxidoreductase; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   793  793     CoB--CoM heterodisulfide reductase 1 iron-sulfur subunit A. PRO_0000150060
DOMAIN   233   264  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   282   311  30     4Fe-4S ferredoxin-type 2. 
DOMAIN   571   600  30     4Fe-4S ferredoxin-type 3. 
DOMAIN   601   629  29     4Fe-4S ferredoxin-type 4. 
NP_BIND   147   170  24     FAD (Potential). 
METAL   243   243        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   246   246        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   250   250        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   254   254        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   291   291        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   294   294        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   297   297        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   301   301        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   580   580        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   583   583        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   586   586        Iron-sulfur 3 (4Fe-4S) (Potential). 
METAL   590   590        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   609   609        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   612   612        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   615   615        Iron-sulfur 4 (4Fe-4S) (Potential). 
METAL   619   619        Iron-sulfur 3 (4Fe-4S) (Potential). 
Sequence information
Length: 793 AA [This is the length of the unprocessed precursor] Molecular weight: 86803 Da [This is the MW of the unprocessed precursor] CRC64: F34517E61FD4B362 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRIGVYVCHC GLNIAGVIDV SALEEMAGEL EDVVLAREVQ FLCSDSGQEG IIKDIKDNKI 

        70         80         90        100        110        120 
DRVVIAACSP RLHEKTFRHV MEKADLNPYL MEMVNIREQC SWVHADDPQM ATQKAFDLIR 

       130        140        150        160        170        180 
MGVAKARFLR ELSATSSKAS RNVLIIGGGV AGIEAALNLA EAGFPVTMVE RESTIGGKMA 

       190        200        210        220        230        240 
LMNEVFPTND CSICVLAPKM TEVQNHPNIT LYTYSEVTDI SGSVGKFHVR VTRKPRFVLE 

       250        260        270        280        290        300 
DKCKGCVDLC SEVCPVEIEN PMNYGIGKSR AIYMPIPQSV PQVVLIDPDH CVGCGLCQLA 

       310        320        330        340        350        360 
CPAEAVDYEQ KPEEIEFEAG AVIVSTGYQL FDASRKKEYG FGKYPDVITN MQLERMLNSA 

       370        380        390        400        410        420 
GPTGGRVLVP STGQPPESVA FIQCVGSRDK TVGNEHCSRV CCMAALKNSQ MVKERYPGTD 

       430        440        450        460        470        480 
ITIHYIDIRA AGEMYEEYYA RTQGMGVDFI RGKVAEVYAG EDGRPVVRYE NTLESRVEEE 

       490        500        510        520        530        540 
AHDLVVLSTG YEPSKAAEGI GRMLNLARRP DRFFASAHPK MRPVDAPVSG VFLAGCASGP 

       550        560        570        580        590        600 
KEIQVSIAQG SACASKVMQL LGTGELEADP MGAHVDPDKC IGCRTCVEVC KFGKISIVDK 

       610        620        630        640        650        660 
KAVVDEVSCY GCGDCSAACP VGAIQMRNFE NEQILAQVRA ATAHKSQCPF VVAFLCNWCS 

       670        680        690        700        710        720 
YACADLTGMS RIHYPTNIRV IRTMCSARIN PEFVLEALKG GADGVLVAGC RMDECHYIHG 

       730        740        750        760        770        780 
NFDAKKRMDV LKEIIKEIGL DPKRLRTLWI SAAEGERFSN TITEFVKELE EIGPIGSELK 

       790 
REYTATGLEE VAK
Q8Q0T0 in FASTA format

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