NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).

Comments

FUNCTION: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction (By similarity).
CATALYTIC ACTIVITY: Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O³-phospho-L-threonine + dihydromethanophenazine.
PATHWAY: Cofactor metabolism; coenzyme B/coenzyme M regeneration; coenzyme B and coenzyme M from CoB-CoM heterodisulfide: step 1/1 .
SUBUNIT: The heterodisulfide reductase 1 is composed of three subunits; hdrA, hdrB and hdrC (By similarity).
SIMILARITY: Belongs to the hdrB family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE008384; AAM30676.1; ALT_INIT; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_633004.1; -.

3D structure databases

ModBase

Q8PY83.

Enzyme and pathway databases

BioCyc

MMAZ192952:MM0980-MON; -.

Ontologies

GO:0051912;	Molecular function: CoB--CoM heterodisulfide reductase activity (inferred from electronic annotation from EC).
GO:0015948;	Biological process: methanogenesis (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR017678; CoB/CoM_hetero-S_rdtase_bsu.
IPR004017; Cys_rich_region.
Graphical view of domain structure.

Pfam

PF02754; CCG; 2.
Pfam graphical view of domain structure.

ProtoNet

Q8PY83.

Genome annotation databases

GeneID

1479322; -.

GenomeReviews

AE008384_GR; MM_0980.

KEGG

mma:MM_0980; -.

NMPDR

fig|192952.1.peg.980; -.

Phylogenomic databases

HOGENOM

Q8PY83; -.

Genome annotation databases

CMR

Q8PY83; MM_0980.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Methanogenesis; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 300`	`300`		`CoB--CoM heterodisulfide reductase 1 subunit B.`	`PRO_0000150068`

Sequence information

Length: 300 AA [This is the length of the unprocessed precursor]

Molecular weight: 33068 Da [This is the MW of the unprocessed precursor]

CRC64: B694E9152DE0A3DE [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNKLSLFLGC IVPNRYPGIE KATKLCLQRL EIDACDLPGA SCCPAPGVFK SFDKATWLAL 

        70         80         90        100        110        120 
ASRNIVLSER MERDVLTVCN GCYGSLADAN MELKKDPEMK ACTNSCLKEI GMEFRGTSEI 

       130        140        150        160        170        180 
RHIIEFLYKE FGPEKLKEYI TTPLDLKVAL HYGCHLIKPS KDRNLGDTES PVFFDELVEA 

       190        200        210        220        230        240 
TGAKSVDYTD KMMCCGAGGG VRSGYADESL EMLEHKLDCI CKAGVDCIVN ACPFCHLQFD 

       250        260        270        280        290        300 
RGQIAVNEKF GTDYSIPVLH YSQLLGLALG FSPDQLGIEQ NAVQNIEFLA KIYEISAGLS

Q8PY83 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools