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[1]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U.,
Johann A.,
Hartsch T.,
Merkl R.,
Schmitz R.A.,
Martinez-Arias R.,
Henne A.,
Wiezer A.,
Baeumer S.,
Jacobi C.,
Brueggemann H.,
Lienard T.,
Christmann A.,
Boemecke M.,
Steckel S.,
Bhattacharyya A.,
Lykidis A.,
Overbeek R.,
Klenk H.-P., ![]()
Gunsalus R.P.,
Fritz H.-J.,
Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
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- FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).
- CATALYTIC ACTIVITY: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
- SIMILARITY: Belongs to the MGMT family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 158 AA [This is the length of the unprocessed precursor] |
Molecular weight: 17996 Da [This is the MW of the unprocessed precursor] |
CRC64: C3E0988D360F019B [This is a checksum on the sequence] |
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10 20 30 40 50 60
MYYHIIKSPI YPILLAGDEK GLKHLIFLKD ERKAKIPNDW VENKDFFREV SNQLEAYFSG
70 80 90 100 110 120
KLKTFDVKLA PQGTEFQKSV WKALCEIPCG ETRTYGEIAK RIQNPKAYRA VGLANNRNPI
130 140 150
AIIVPCHRVI GANGKLTGYA SGLDIKEFLL KLEENNLK
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Q8PY44 in FASTA format |
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