NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
PubMed=12125824 [NCBI, ExPASy, EBI, Israel, Japan]
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.;
"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.";
J. Mol. Microbiol. Biotechnol. 4:453-461(2002).

Comments

CATALYTIC ACTIVITY: Peptide-L-methionine + thioredoxin disulfide + H₂O = peptide-L-methionine (R)-S-oxide + thioredoxin.
COFACTOR: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein (By similarity).
SIMILARITY: Belongs to the msrB Met sulfoxide reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AE008384; AAM31330.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_633658.1; -.

3D structure databases

HSSP

P14930; 1L1D. [HSSP ENTRY / PDB]

ModBase

Q8PWF5.

Enzyme and pathway databases

BioCyc

MMAZ192952:MM1634-MON; -.

Ontologies

GO:0033743;	Molecular function: peptide-methionine (R)-S-oxide reductase activity (inferred from electronic annotation from EC).
GO:0008113;	Molecular function: peptide-methionine-(S)-S-oxide reductase activity (inferred from electronic annotation from HAMAP).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_01400; -; 1.
PBIL [Tree]

InterPro

IPR002579; MsrB.
Graphical view of domain structure.

Gene3D

G3DSA:2.170.150.20; MsrB; 1.

Pfam

PF01641; SelR; 1.
Pfam graphical view of domain structure.

ProDom

PD004057; DUF25; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR00357; MsrB; 1.

ProtoNet

Q8PWF5.

Genome annotation databases

GeneID

1479976; -.

GenomeReviews

AE008384_GR; MM_1634.

KEGG

mma:MM_1634; -.

NMPDR

fig|192952.1.peg.1634; -.

Phylogenomic databases

HOGENOM

Q8PWF5; -.

Genome annotation databases

CMR

Q8PWF5; MM_1634.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Metal-binding; Oxidoreductase; Zinc.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 140`	`140`	`Peptide methionine sulfoxide reductase msrB.`	`PRO_1000068279`
`ACT_SITE`	`121 121`		`Nucleophile (By similarity).`
`METAL`	`49 49`		`Zinc (By similarity).`
`METAL`	`52 52`		`Zinc (By similarity).`
`METAL`	`98 98`		`Zinc (By similarity).`
`METAL`	`101 101`		`Zinc (By similarity).`

Sequence information

Length: 140 AA [This is the length of the unprocessed precursor]

Molecular weight: 16038 Da [This is the MW of the unprocessed precursor]

CRC64: 8D0E0710D963DED2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAQNKIEKSE EDWKSVLTPE QYHVLRQKGT ERPFSGNLYY NKEKGIYTCA ACGQELFSSD 

        70         80         90        100        110        120 
TKFESGTGWP SFYDVISSDR VRLHEDNSYF MKRIEVVCSR CGSHLGHVFE DGPEPTGQRY 

       130        140 
CINSVSLGFT KEEDTGKEKE

Q8PWF5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools