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UniProtKB/Swiss-Prot entry Q8P2B4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MURE_STRP8
Primary accession number Q8P2B4
Secondary accession numbers None
Integrated into Swiss-Prot on November 25, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
Synonyms EC 6.3.2.7
UDP-MurNAc-L-Ala-D-Glu:L-Lys ligase
L-lysine-adding enzyme
UDP-N-acetylmuramyl-tripeptide synthetase
UDP-MurNAc-tripeptide synthetase
Gene name
Name: murE
OrderedLocusNames: spyM18_0440
From
Streptococcus pyogenes serotype M18 [TaxID: 301451] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MGAS8232 / Serotype M18;
DOI=10.1073/pnas.062526099; PubMed=11917108 [NCBI, ExPASy, EBI, Israel, Japan]
Smoot J.C., Barbian K.D., Van Gompel J.J., Smoot L.M., Chaussee M.S., Sylva G.L., Sturdevant D.E., Ricklefs S.M., Porcella S.F., Parkins L.D., Beres S.B., Campbell D.S., Smith T.M., Zhang Q., Kapur V., Daly J.A., Veasy L.G., Musser J.M.;
"Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks.";
Proc. Natl. Acad. Sci. U.S.A. 99:4668-4673(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE009984; AAL97178.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_606679.1; -.
3D structure databases
HSSP P22188; 1E8C. [HSSP ENTRY / PDB]
ModBase Q8P2B4.
Enzyme and pathway databases
BioCyc SPYO186103:SPYM18_0440-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0047482; Molecular function: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity (inferred from electronic annotation from EC).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301; Biological process: cell division (inferred from electronic annotation from InterPro).
GO:0009252; Biological process: peptidoglycan biosynthetic process (inferred from electronic annotation from HAMAP).
GO:0008360; Biological process: regulation of cell shape (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
HAMAP MF_00208; -; 1.
PBIL [Tree]
InterPro IPR004101; Mur_ligase_C.
IPR013221; Mur_ligase_cen.
IPR005761; UDP-N-AcMur-Glu-dNH2Pim_ligase.
Graphical view of domain structure.
Gene3D G3DSA:3.90.190.20; Mur_ligase_C; 1.
G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
Pfam PF02875; Mur_ligase_C; 1.
PF08245; Mur_ligase_M; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01085; murE; 1.
ProtoNet Q8P2B4.
Genome annotation databases
GeneID 995254; -.
GenomeReviews AE009949_GR; spyM18_0440.
KEGG spm:spyM18_0440; -.
Phylogenomic databases
HOGENOM Q8P2B4; -.
Genome annotation databases
CMR Q8P2B4; spyM18_0440.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Cell cycle; Cell division; Cell shape; Cell wall biogenesis/degradation; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Peptidoglycan synthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   481  481     UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase. PRO_0000101958
NP_BIND   118   124  7     ATP (Potential). 
REGION   160   161  2     UDP-MurNAc-L-Ala-D-Glu binding (By similarity). 
MOTIF   404   407  4     L-lysine recognition motif. 
BINDING   42    42        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
BINDING   158   158        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
BINDING   187   187        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
BINDING   195   195        UDP-MurNAc-L-Ala-D-Glu (By similarity). 
MOD_RES   229   229        N6-carboxylysine (By similarity). 
Sequence information
Length: 481 AA [This is the length of the unprocessed precursor] Molecular weight: 53479 Da [This is the MW of the unprocessed precursor] CRC64: B630BA6E4E7F51E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MITIEQLLDI LKKDHNFREV LDADGYHYHY QGLSFERLSY DSRQVDGKTL FFAKGATFKA 

        70         80         90        100        110        120 
DYLKEAITNG LQLYISEVDY ELGIPVVLVT DIKKAMSLIA MAFYGNPQEK LKLLAFTGTK 

       130        140        150        160        170        180 
GKTTAAYFAY HMLKESYKPA MFSTMNTTLD GKTFFKSQLT TPESLDLFAM MAECVTNGMT 

       190        200        210        220        230        240 
HLIMEVSSQA YLVDRVYGLT FDVGVFLNIS PDHIGPIEHP TFEDYFYHKR LLMENSRAVV 

       250        260        270        280        290        300 
INSGMDHFSF LADQVADQEH VFYGPLSDNQ ITTSQAFSFE AKGQLAGHYD IQLIGHFNQE 

       310        320        330        340        350        360 
NAMAAGLACL RLGASLADIQ KGIAKTRVPG RMEVLTMTNH AKVFVDYAHN GDSLEKLLSV 

       370        380        390        400        410        420 
VEEHQTGKLM LILGAPGNKG ESRRADFGRV IHQHPNLTVI LTADDPNFED PEDISKEIAS 

       430        440        450        460        470        480 
HIARPVEIIS DREQAIQKAM SLCQGAKDAV IIAGKGADAY QIVKGQQVAY AGDLAIAKHY 


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Q8P2B4 in FASTA format

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