NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1016/S0140-6736(02)08713-5; PubMed=12044378 [NCBI, ExPASy, EBI, Israel, Japan]
Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y., Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
"Genome and virulence determinants of high virulence community-acquired MRSA.";
Lancet 359:1819-1827(2002).

Comments

FUNCTION: Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).
CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
PATHWAY: Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis .
SIMILARITY: Belongs to the UDPGP type 2 family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BA000033; BAB96284.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_647236.1; -.

3D structure databases

HSSP

P26393; 1IIN. [HSSP ENTRY / PDB]

ModBase

Q8NUU9.

Enzyme and pathway databases

BioCyc

SAUR196620:MW2419-MON; -.

Ontologies

GO:0003983;	Molecular function: UTP:glucose-1-phosphate uridylyltransferase activity (inferred from electronic annotation from InterPro).
GO:0009058;	Biological process: biosynthetic process (inferred from electronic annotation from InterPro).
GO:0006011;	Biological process: UDP-glucose metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR005771; GalU_trans_bac.
IPR005835; NTP_transferase.
Graphical view of domain structure.

Pfam

PF00483; NTP_transferase; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01099; galU; 1.

ProtoNet

Q8NUU9.

Genome annotation databases

GeneID

1004555; -.

GenomeReviews

BA000033_GR; MW2419.

KEGG

sam:MW2419; -.

Phylogenomic databases

HOGENOM

Q8NUU9; -.

Genome annotation databases

CMR

Q8NUU9; MW2419.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carbohydrate metabolism; Complete proteome; Nucleotidyltransferase; Transferase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 288`	`288`		`UTP--glucose-1-phosphate uridylyltransferase.`	`PRO_0000308309`

Sequence information

Length: 288 AA [This is the length of the unprocessed precursor]

Molecular weight: 32509 Da [This is the MW of the unprocessed precursor]

CRC64: 126BF003999D4418 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGRH 

        70         80         90        100        110        120 
KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF YVRQKEQKGL GHAISSARQF 

       130        140        150        160        170        180 
IGNEPFAVLL GDDIVESEVP AVKQLIDVYE ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG 

       190        200        210        220        230        240 
RQYEVKKFVE KPAQGTAPSN LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND 

       250        260        270        280 
NQVYAYDFEG ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKELGL

Q8NUU9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools