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UniProtKB/Swiss-Prot entry Q8NQ98

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACON_CORGL
Primary accession number Q8NQ98
Secondary accession numbers Q6M550 Q9WXJ0
Integrated into Swiss-Prot on February 7, 2006
Sequence was last modified on February 7, 2006 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 46)
Name and origin of the protein
Protein name Aconitate hydratase
Synonym EC 4.2.1.3
Gene name
Name: acn
OrderedLocusNames: Cgl1540, cg1737
From
Corynebacterium glutamicum (Brevibacterium flavum) [TaxID: 1718] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Corynebacteriaceae; Corynebacterium.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 13869 / DSMZ 1412 / NCIMB 9567;
Nakamura J., Kimura E., Oosumi T., Matsui K., Nakamatsu T.;
"Brevibacterium lactofermentum ATCC 13869 acn gene for aconitase.";
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
Nakagawa S.;
"Complete genomic sequence of Corynebacterium glutamicum ATCC 13032.";
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025;
DOI=10.1016/S0168-1656(03)00154-8; PubMed=12948626 [NCBI, ExPASy, EBI, Israel, Japan]
Kalinowski J., Bathe B., Bartels D., Bischoff N., Bott M., Burkovski A., Dusch N., Eggeling L., Eikmanns B.J., Gaigalat L., Goesmann A., Hartmann M., Huthmacher K., Kraemer R., Linke B., McHardy A.C., Meyer F., Moeckel B., Pfefferle W., Puehler A., Rey D.A., Rueckert C., Rupp O., Sahm H., Wendisch V.F., Wiegraebe I., Tauch A.;
"The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of L-aspartate-derived amino acids and vitamins.";
J. Biotechnol. 104:5-25(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB025424; BAA76717.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BA000036; BAB98933.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX927152; CAF21548.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_600755.1; -.
YP_225824.1; -.
3D structure databases
ModBase Q8NQ98.
Enzyme and pathway databases
BioCyc CGLU196627-1:CG1737-MON; -.
2D gel databases
World-2DPAGE 0001:Q8NQ98; -.
Ontologies
GO
GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding (inferred from electronic annotation from InterPro).
GO:0003994; Molecular function: aconitate hydratase activity (inferred from electronic annotation from EC).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
IPR001030; Acoase/IPM_deHydtase_lsu_aba.
IPR015937; Aconitase-like_core.
IPR015928; Aconitase/3IPM_dehydase_swvl.
IPR006249; Aconitase/Fe_reg_prot_2.
IPR015934; Aconitase/Fe_reg_prot_2/AcnD.
IPR015932; Aconitase/IPMdHydase_lsu_aba_2.
IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
Graphical view of domain structure.
Gene3D G3DSA:3.30.499.10; Acnase/IPM_dHydase_lsu_aba_1/3; 2.
G3DSA:3.20.19.10; Aconitase/3IPM_dehydase_swvl; 1.
G3DSA:3.40.1060.10; Aconitase/IPMdHydase_lsu_aba_2; 1.
PANTHER PTHR11670; Aconitase-like_core; 1.
PTHR11670:SF1; Aconitase/Fe_reg_prot_2/AcnD; 1.
Pfam PF00330; Aconitase; 1.
PF00694; Aconitase_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00415; ACONITASE.
ProDom PD000511; Aconitase_N; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01341; aconitase_1; 1.
PROSITE PS00450; ACONITASE_1; 1.
PS01244; ACONITASE_2; 1.
ProtoNet Q8NQ98.
Genome annotation databases
GeneID 1019512; -.
3344469; -.
GenomeReviews BX927147_GR; cg1737.
BA000036_GR; Cgl1540.
KEGG cgb:cg1737; -.
cgl:NCgl1482; -.
Phylogenomic databases
HOGENOM Q8NQ98; -.
Genome annotation databases
CMR Q8NQ98; Cgl1540.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Iron; Iron-sulfur; Lyase; Metal-binding; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   939  939     Aconitate hydratase. PRO_0000076657
METAL   475   475        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   541   541        Iron-sulfur (4Fe-4S) (By similarity). 
METAL   544   544        Iron-sulfur (4Fe-4S) (By similarity). 
CONFLICT   71    71        D -> N (in Ref. 1; BAA76717). 
CONFLICT   122   122        M -> V (in Ref. 1; BAA76717). 
CONFLICT   555   555        I -> Y (in Ref. 1; BAA76717). 
CONFLICT   745   745        N -> Y (in Ref. 1; BAA76717). 
CONFLICT   888   888        T -> I (in Ref. 1; BAA76717). 
Sequence information
Length: 939 AA [This is the length of the unprocessed precursor] Molecular weight: 101726 Da [This is the MW of the unprocessed precursor] CRC64: 3488BCA190A07F13 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTESKNSFNA KSTLEVGDKS YDYFALSAVP GMEKLPYSLK VLGENLLRTE DGANITNEHI 

        70         80         90        100        110        120 
EAIANWDASS DPSIEIQFTP ARVLMQDFTG VPCVVDLATM REAVAALGGD PNDVNPLNPA 

       130        140        150        160        170        180 
EMVIDHSVIV EAFGRPDALA KNVEIEYERN EERYQFLRWG SESFSNFRVV PPGTGIVHQV 

       190        200        210        220        230        240 
NIEYLARVVF DNEGLAYPDT CIGTDSHTTM ENGLGILGWG VGGIEAEAAM LGQPVSMLIP 

       250        260        270        280        290        300 
RVVGFKLTGE IPVGVTATDV VLTITEMLRD HGVVQKFVEF YGSGVKAVPL ANRATIGNMS 

       310        320        330        340        350        360 
PEFGSTCAMF PIDEETTKYL RLTGRPEEQV ALVEAYAKAQ GMWLDEDTVE AEYSEYLELD 

       370        380        390        400        410        420 
LSTVVPSIAG PKRPQDRILL SEAKEQFRKD LPTYTDDAVS VDTSIPATRM VNEGGGQPEG 

       430        440        450        460        470        480 
GVEADNYNAS WAGSGESLAT GAEGRPSKPV TVASPQGGEY TIDHGMVAIA SITSCTNTSN 

       490        500        510        520        530        540 
PSVMIGAGLI ARKAAEKGLK SKPWVKTICA PGSQVVDGYY QRADLWKDLE AMGFYLSGFG 

       550        560        570        580        590        600 
CTTCIGNSGP LPEEISAAIN EHDLTATAVL SGNRNFEGRI SPDVKMNYLA SPIMVIAYAI 

       610        620        630        640        650        660 
AGTMDFDFEN EALGQDQDGN DVFLKDIWPS TEEIEDTIQQ AISRELYEAD YADVFKGDKQ 

       670        680        690        700        710        720 
WQELDVPTGD TFEWDENSTY IRKAPYFDGM PVEPVAVTDI QGARVLAKLG DSVTTDHISP 

       730        740        750        760        770        780 
ASSIKPGTPA AQYLDEHGVE RHDYNSLGSR RGNHEVMMRG TFANIRLQNQ LVDIAGGYTR 

       790        800        810        820        830        840 
DFTQEGAPQA FIYDASVNYK AAGIPLVVLG GKEYGTGSSR DWAAKGTNLL GIRAVITESF 

       850        860        870        880        890        900 
ERIHRSNLIG MGVVPLQFPA GESHESLGLD GTETFDITGL TALNEGETPK TVKVTATKEN 

       910        920        930 
GDVVEFDAVV RIDTPGEADY YRHGGILQYV LRQMAASSK
Q8NQ98 in FASTA format

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