ID   DCXR_TRIRE              Reviewed;         266 AA.
AC   Q8NK50;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-NOV-2008, entry version 30.
DE   RecName: Full=L-xylulose reductase;
DE            Short=XR;
DE            EC=1.1.1.10;
GN   Name=lxr1;
OS   Trichoderma reesei (Hypocrea jecorina).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae;
OC   Hypocrea.
OX   NCBI_TaxID=51453;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ENZYME ACTIVITY.
RX   MEDLINE=22005794; PubMed=12009906; DOI=10.1021/bi025529i;
RA   Richard P., Putkonen M., Vaeaenaenen R., Londesborough J.,
RA   Penttilae M.;
RT   "The missing link in the fungal L-arabinose catabolic pathway,
RT   identification of the L-xylulose reductase gene.";
RL   Biochemistry 41:6432-6437(2002).
CC   -!- FUNCTION: Catalyzes the NADPH-dependent reduction of L-xylulose,
CC       D-xylulose, D-fructose, and L-sorbose, with the highest affinity
CC       for L-xylulose.
CC   -!- CATALYTIC ACTIVITY: Xylitol + NADP(+) = L-xylulose + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; L-arabinose degradation via L-
CC       arabinitol; D-xylulose 5-phosphate from L-arabinose (fungi route):
CC       step 3/5.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; AF375616; AAM20896.1; -; mRNA.
DR   HSSP; Q9ZFY9; 1FK8.
DR   BioCyc; MetaCyc:MON-13194; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0050038; F:L-xylulose reductase activity; IEA:EC.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Carbohydrate metabolism; NADP; Oxidoreductase; Xylose metabolism.
FT   CHAIN         1    266       L-xylulose reductase.
FT                                /FTId=PRO_0000054558.
FT   NP_BIND      23     53       NADP (By similarity).
FT   ACT_SITE    174    174       Proton acceptor (By similarity).
FT   ACT_SITE    178    178       By similarity.
FT   BINDING     159    159       Substrate (By similarity).
SQ   SEQUENCE   266 AA;  28478 MW;  1CF56334DA86F109 CRC64;
     MPQPVPTANR LLDLFSLKGK VVVVTGASGP RGMGIEAARG CAEMGADLAI TYSSRKEGAE
     KNAEELTKEY GVKVKVYKVN QSDYNDVERF VNQVVSDFGK IDAFIANAGA TANSGVVDGS
     ASDWDHVIQV DLSGTAYCAK AVGAHFKKQG HGSLVITASM SGHVANYPQE QTSYNVAKAG
     CIHLARSLAN EWRDFARVNS ISPGYIDTGL SDFIDEKTQE LWRSMIPMGR NGDAKELKGA
     YVYLVSDASS YTTGADIVID GGYTTR
//