[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."; Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
[2]	IDENTIFICATION. DOI=10.1073/pnas.0307882100; PubMed=14983052 [NCBI, ExPASy, EBI, Israel, Japan] Malnic B., Godfrey P.A., Buck L.B.; "The human olfactory receptor gene family."; Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
[3]	TISSUE SPECIFICITY. DOI=10.1186/gb-2007-8-5-r86; PubMed=17509148 [NCBI, ExPASy, EBI, Israel, Japan] Zhang X., De la Cruz O., Pinto J.M., Nicolae D., Firestein S., Gilad Y.; "Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray."; Genome Biol. 8:RESEARCH0086.1-RESEARCH0086.10(2007).
[4]	VARIANTS GLY-52; CYS-75; LEU-79; ASN-84; TRP-88; GLN-131; MET-133; I-136; ARG-139; TYR-139; PRO-162; ASP-279 AND MET-292. DOI=10.1038/nature06162; PubMed=17873857 [NCBI, ExPASy, EBI, Israel, Japan] Keller A., Zhuang H., Chi Q., Vosshall L.B., Matsunami H.; "Genetic variation in a human odorant receptor alters odour perception."; Nature 449:468-472(2007).

Comments

FUNCTION: Odorant receptor. Selectively activated by androstenone and the related odorous steroid androstadienone.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Nasal olfactory epithelium.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family [view classification].
WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); URL="http://bip.weizmann.ac.il/cgi-bin/HORDE/showGene.pl?key=symbol&value=OR7D4";.
WEB RESOURCE: Name=Protein Spotlight; Note=The selfish smell -Issue 94 of May 2008; URL="http://www.expasy.org/spotlight/back_issues/sptlt094.shtml";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB065929; BAC06144.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BK004226; DAA04624.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001005191.1; -.

UniGene

Hs.446910

3D structure databases

ModBase

Q8NG98.

Protein family/group databases

GPCRDB

Q8NG98; OR7D4_HUMAN.

Organism-specific databases

HIX0040177; -.

HGNC:8380; OR7D4.

611538; gene. [NCBI / EBI]

PharmGKB

PA32628; -.

GeneCards

Q8NG98.

Gene expression databases

CleanEx

HS_OR7D4; -.

Family and domain databases

InterPro

IPR000276; GPCR_Rhodpsn.
IPR017452; GPCR_Rhodpsn_supfam.
IPR000725; Olfact_rcpt.
Graphical view of domain structure.

PANTHER

PTHR11398; Olfact_rcpt; 1.

Pfam

PF00001; 7tm_1; 1.
Pfam graphical view of domain structure.

PRINTS

PR00237; GPCRRHODOPSN.
PR00245; OLFACTORYR.

PROSITE

PS00237; G_PROTEIN_RECEP_F1_1; 1.
PS50262; G_PROTEIN_RECEP_F1_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q8NG98.

Genome annotation databases

Ensembl

ENSG00000174667; Homo sapiens. [Contig view]

GeneID

125958; -.

KEGG

hsa:125958; -.

Phylogenomic databases

HOGENOM

Q8NG98; -.

HOVERGEN

Q8NG98; -.

Other

Q8NG98; -.

OR7D4; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; Polymorphism; Receptor; Sensory transduction; Transducer; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 312`	`312`	`Olfactory receptor 7D4.`	`PRO_0000150649`
`TOPO_DOM`	`1 25`	`25`	`Extracellular (Potential).`
`TRANSMEM`	`26 46`	`21`	`1 (Potential).`
`TOPO_DOM`	`47 54`	`8`	`Cytoplasmic (Potential).`
`TRANSMEM`	`55 75`	`21`	`2 (Potential).`
`TOPO_DOM`	`76 99`	`24`	`Extracellular (Potential).`
`TRANSMEM`	`100 120`	`21`	`3 (Potential).`
`TOPO_DOM`	`121 139`	`19`	`Cytoplasmic (Potential).`
`TRANSMEM`	`140 160`	`21`	`4 (Potential).`
`TOPO_DOM`	`161 197`	`37`	`Extracellular (Potential).`
`TRANSMEM`	`198 217`	`20`	`5 (Potential).`
`TOPO_DOM`	`218 237`	`20`	`Cytoplasmic (Potential).`
`TRANSMEM`	`238 258`	`21`	`6 (Potential).`
`TOPO_DOM`	`259 271`	`13`	`Extracellular (Potential).`
`TRANSMEM`	`272 292`	`21`	`7 (Potential).`
`TOPO_DOM`	`293 312`	`20`	`Cytoplasmic (Potential).`
`CARBOHYD`	`5 5`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`97 189`		`By similarity.`
`VARIANT`	`52 52`	`1`	`D -> G.`	`VAR_037778`
`VARIANT`	`75 75`	`1`	`S -> C (in dbSNP:rs5020281 [NCBI]).`	`VAR_037779`
`VARIANT`	`79 79`	`1`	`P -> L (impaired response to androstenone and androstadienone).`	`VAR_037780`
`VARIANT`	`84 84`	`1`	`S -> N (high sensitivity to androstenone and androstadienone; dbSNP:rs5020280 [NCBI]).`	`VAR_037781`
`VARIANT`	`88 88`	`1`	`R -> W (impaired response to androstenone and androstadienone; when associated with M-133).`	`VAR_037782`
`VARIANT`	`131 131`	`1`	`H -> Q (in dbSNP:rs5020279 [NCBI]).`	`VAR_037783`
`VARIANT`	`133 133`	`1`	`T -> M (impaired response to androstenone and androstadienone; when associated with W-88; dbSNP:rs5020278 [NCBI]).`	`VAR_037784`
`VARIANT`	`136 136`	`1`	`M -> I (in dbSNP:rs5020277 [NCBI]).`	`VAR_037785`
`VARIANT`	`139 139`	`1`	`C -> R (in dbSNP:rs5020276 [NCBI]).`	`VAR_037786`
`VARIANT`	`139 139`	`1`	`C -> Y (in dbSNP:rs5020275 [NCBI]).`	`VAR_037787`
`VARIANT`	`162 162`	`1`	`L -> P.`	`VAR_037788`
`VARIANT`	`279 279`	`1`	`A -> D.`	`VAR_037789`
`VARIANT`	`292 292`	`1`	`L -> M (in dbSNP:rs4564704 [NCBI]).`	`VAR_037790`

Sequence information

Length: 312 AA [This is the length of the unprocessed precursor]

Molecular weight: 34448 Da [This is the MW of the unprocessed precursor]

CRC64: FD97DD41B890B085 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY 

        70         80         90        100        110        120 
FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ VYFLMMFAGM DTFLLAVMAY 

       130        140        150        160        170        180 
DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE 

       190        200        210        220        230        240 
PAQVLKVACS NTLLNNIVLY VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST 

       250        260        270        280        290        300 
CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 

       310 
LERLLSRADS CP

Q8NG98 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools