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UniProtKB/Swiss-Prot entry Q8NG68

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TTL_HUMAN
Primary accession number Q8NG68
Secondary accession numbers Q7Z302 Q8N426
Integrated into Swiss-Prot on May 10, 2004
Sequence was last modified on March 1, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name Tubulin--tyrosine ligase
Synonyms TTL
EC 6.3.2.25
Gene name
Name: TTL
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Miyazaki K., Okamoto Y., Kato C., Sakamoto M., Ohira M., Morohashi A., Nakagawara A.;
"Homo sapiens tubulin tyrosine ligase mRNA, complete cds.";
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 205-377.
TISSUE=Uterus;
The German cDNA consortium;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB071393; BAC06832.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC036819; AAH36819.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX538316; CAD98091.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_714923.1; -.
UniGene Hs.358997
3D structure databases
ModBase Q8NG68.
PTM databases
PhosphoSite Q8NG68; -.
Organism-specific databases
HGNC HGNC:21586; TTL.
GenAtlas TTL.
MIM 608291; gene. [NCBI / EBI]
PharmGKB PA134934330; -.
GeneCards Q8NG68.
Gene expression databases
ArrayExpress Q8NG68; -.
CleanEx HS_TTL; -.
GermOnline ENSG00000114999; Homo sapiens.
Ontologies
GO
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0030955; Molecular function: potassium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004835; Molecular function: tubulin-tyrosine ligase activity (inferred from electronic annotation from InterPro).
GO:0006464; Biological process: protein modification process (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR004344; Tub_tyr_ligase.
Graphical view of domain structure.
PANTHER PTHR12241; Tub_tyr_ligase; 1.
Pfam PF03133; TTL; 1.
Pfam graphical view of domain structure.
PROSITE PS51221; TTL; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8NG68.
Proteomic databases
PeptideAtlas Q8NG68; -.
Genome annotation databases
Ensembl ENSG00000114999; Homo sapiens. [Contig view]
GeneID 150465; -.
KEGG hsa:150465; -.
Phylogenomic databases
HOGENOM Q8NG68; -.
HOVERGEN Q8NG68; -.
Other
LinkHub Q8NG68; -.
NextBio 86445; -.
SOURCE TTL; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Ligase; Magnesium; Potassium.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   377  377     Tubulin--tyrosine ligase. PRO_0000212434
DOMAIN   3   370  368     TTL. 
CONFLICT   245   245        I -> V (in Ref. 3; CAD98091). 
Sequence information
Length: 377 AA [This is the length of the unprocessed precursor] Molecular weight: 43212 Da [This is the MW of the unprocessed precursor] CRC64: 7A13E2C28E1AD6EA [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MYTFVVRDEN SSVYAEVSRL LLATGHWKRL RRDNPRFNLM LGERNRLPFG RLGHEPGLVQ 

        70         80         90        100        110        120 
LVNYYRGADK LCRKASLVKL IKTSPELAES CTWFPESYVI YPTNLKTPVA PAQNGIQPPI 

       130        140        150        160        170        180 
SNSRTDEREF FLASYNRKKE DGEGNVWIAK SSAGAKGEGI LISSEASELL DFIDNQGQVH 

       190        200        210        220        230        240 
VIQKYLEHPL LLEPGHRKFD IRSWVLVDHQ YNIYLYREGV LRTASEPYHV DNFQDKTCHL 

       250        260        270        280        290        300 
TNHCIQKEYS KNYGKYEEGN EMFFKEFNQY LTSALNITLE SSILLQIKHI IRNCLLSVEP 

       310        320        330        340        350        360 
AISTKHLPYQ SFQLFGFDFM VDEELKVWLI EVNGAPACAQ KLYAELCQGI VDIAISSVFP 

       370 
PPDVEQPQTQ PAAFIKL
Q8NG68 in FASTA format

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