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UniProtKB/Swiss-Prot entry Q8NFZ8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CADM4_HUMAN
Primary accession number Q8NFZ8
Secondary accession numbers B2R7L5 Q9Y4A4
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 51)
Name and origin of the protein
Protein name Cell adhesion molecule 4 [Precursor]
Synonyms Immunoglobulin superfamily member 4C
Nectin-like protein 4
TSLC1-like protein 2
Gene name
Name: CADM4
Synonyms: IGSF4C, NECL4, TSLL2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
DOI=10.1038/sj.onc.1204696; PubMed=11536053 [NCBI, ExPASy, EBI, Israel, Japan]
Fukuhara H., Kuramochi M., Nobukuni T., Fukami T., Saino M., Maruyama T., Nomura S., Sekiya T., Murakami Y.;
"Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins.";
Oncogene 20:5401-5407(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Amygdala;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02399; PubMed=15057824 [NCBI, ExPASy, EBI, Israel, Japan]
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[4]
FUNCTION, SUBUNIT, AND TISSUE SPECIFICITY.
DOI=10.1038/sj.onc.1209192; PubMed=16261159 [NCBI, ExPASy, EBI, Israel, Japan]
Williams Y.N., Masuda M., Sakurai-Yageta M., Maruyama T., Shibuya M., Murakami Y.;
"Cell adhesion and prostate tumor-suppressor activity of TSLL2/IGSF4C, an immunoglobulin superfamily molecule homologous to TSLC1/IGSF4.";
Oncogene 25:1446-1453(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF363368; AAM60750.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK313028; BAG35862.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC005525; AAC32740.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00176427; -.
RefSeq NP_660339.1; -.
UniGene Hs.370984
3D structure databases
ModBase Q8NFZ8.
PTM databases
PhosphoSite Q8NFZ8; -.
Organism-specific databases
GeneCards GC19M048821; -.
HGNC HGNC:30825; CADM4.
GenAtlas CADM4.
HPA HPA012612; -.
MIM 609744; gene. [NCBI / EBI]
Gene expression databases
ArrayExpress Q8NFZ8; -.
Bgee Q8NFZ8; -.
CleanEx HS_CADM4; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from UniProtKB-KW).
GO:0007155; Biological process: cell adhesion (inferred from electronic annotation from UniProtKB-KW).
GO:0007049; Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0045786; Biological process: negative regulation of cell cycle (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR013162; CD80_C2-set.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013106; Ig_V-set.
IPR003585; Neurexin-like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF08205; C2-set_2; 1.
PF07679; I-set; 1.
PF07686; V-set; 1.
Pfam graphical view of domain structure.
SMART SM00294; 4.1m; 1.
SM00409; IG; 2.
SM00408; IGc2; 1.
SMART graphical view of domain structure.
PROSITE PS50835; IG_LIKE; 2.
PROSITE graphical view of domain structure (profiles).
Proteomic databases
PeptideAtlas Q8NFZ8; -.
PRIDE Q8NFZ8; -.
Genome annotation databases
Ensembl ENSG00000105767; Homo sapiens. [Contig view]
GeneID 199731; -.
KEGG hsa:199731; -.
Phylogenomic databases
HOGENOM Q8NFZ8; -.
HOVERGEN Q8NFZ8; -.
OMA Q8NFZ8; MGRARRF.
Other
NextBio 89714; -.
SOURCE CADM4; Homo sapiens.
ProtoNet Q8NFZ8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Anti-oncogene; Cell adhesion; Cell cycle; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   388  368     Cell adhesion molecule 4. PRO_0000291980
TOPO_DOM   21   324  304     Extracellular (Potential). 
TRANSMEM   325   345  21     Potential. 
TOPO_DOM   346   388  43     Cytoplasmic (Potential). 
DOMAIN   21   119  99     Ig-like V-type. 
DOMAIN   124   219  96     Ig-like C2-type 1. 
DOMAIN   224   307  84     Ig-like C2-type 2. 
CARBOHYD   31    31        N-linked (GlcNAc...) (Potential). 
CARBOHYD   67    67        N-linked (GlcNAc...) (Potential). 
CARBOHYD   286   286        N-linked (GlcNAc...) (Potential). 
DISULFID   44   104        By similarity. 
DISULFID   145   199        By similarity. 
DISULFID   245   291        By similarity. 
VARIANT   225   225  1     T -> A (in dbSNP:rs34246023 [NCBI]). VAR_032906 
Sequence information
Length: 388 AA [This is the length of the unprocessed precursor] Molecular weight: 42785 Da [This is the MW of the unprocessed precursor] CRC64: B22301C9E21A9339 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA 

        70         80         90        100        110        120 
RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV 

       130        140        150        160        170        180 
LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAATLRWYR DRKELKGVSS SQENGKVWSV 

       190        200        210        220        230        240 
ASTVRFRVDR KDDGGIIICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT 

       250        260        270        280        290        300 
LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA 

       310        320        330        340        350        360 
RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA 

       370        380 
SGLDEQGEAR EAFLNGSDGH KRKEEFFI 

Q8NFZ8 in FASTA format

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