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UniProtKB/Swiss-Prot entry Q8NFT8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DNER_HUMAN
Primary accession number Q8NFT8
Secondary accession numbers A6NP39 Q53R88 Q53TP7 Q53TQ5 Q8IYT0 Q8TB42 Q9NTF1 Q9UDM2
Integrated into Swiss-Prot on October 17, 2006
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 48)
Name and origin of the protein
Protein name Delta and Notch-like epidermal growth factor-related receptor [Precursor]
Synonyms None
Gene name
Name: DNER
Synonyms: BET
ORFNames: UNQ262/PRO299
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1074/jbc.M110793200; PubMed=11950833 [NCBI, ExPASy, EBI, Israel, Japan]
Eiraku M., Hirata Y., Takeshima H., Hirano T., Kengaku M.;
"Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.";
J. Biol. Chem. 277:25400-25407(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature03466; PubMed=15815621 [NCBI, ExPASy, EBI, Israel, Japan]
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.;
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4.";
Nature 434:724-731(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-433.
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-737.
TISSUE=Amygdala;
The German cDNA consortium;
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
[7]
TISSUE SPECIFICITY.
DOI=10.1097/00001756-200205070-00035; PubMed=11997712 [NCBI, ExPASy, EBI, Israel, Japan]
Nishizumi H., Komiyama T., Miyabayashi T., Sakano S., Sakano H.;
"BET, a novel neuronal transmembrane protein with multiple EGF-like motifs.";
NeuroReport 13:909-915(2002).
[8]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-223, AND MASS SPECTROMETRY.
TISSUE=Saliva;
DOI=10.1021/pr050492k; PubMed=16740002 [NCBI, ExPASy, EBI, Israel, Japan]
Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.;
"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.";
J. Proteome Res. 5:1493-1503(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF442487; AAM21557.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358891; AAQ89250.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC007559; AAY14939.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC007748; AAY24263.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC008273; AAF19247.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AC093384; AAY14680.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
CH471063; EAW70893.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC024766; AAH24766.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC035009; AAH35009.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL137311; CAB70690.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T46247; T46247.
RefSeq NP_620711.3; -.
UniGene Hs.234074
3D structure databases
HSSP P00740; 1EDM. [HSSP ENTRY / PDB]
ModBase Q8NFT8.
PTM databases
PhosphoSite Q8NFT8; -.
Organism-specific databases
HGNC HGNC:24456; DNER.
GenAtlas DNER.
HPA HPA017320; -.
MIM 607299; gene. [NCBI / EBI]
GeneCards Q8NFT8.
Gene expression databases
ArrayExpress Q8NFT8; -.
GermOnline ENSG00000187957; Homo sapiens.
Ontologies
GO
GO:0030425; Cellular component: dendrite (inferred from direct assay from UniProtKB).
GO:0005769; Cellular component: early endosome (inferred from direct assay from UniProtKB).
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005886; Cellular component: plasma membrane (inferred from direct assay from UniProtKB).
GO:0005509; Molecular function: calcium ion binding (non-traceable author statement from UniProtKB).
GO:0030276; Molecular function: clathrin binding (traceable author statement from UniProtKB).
GO:0004888; Molecular function: transmembrane receptor activity (traceable author statement from UniProtKB).
GO:0007417; Biological process: central nervous system development (inferred from expression pattern from UniProtKB).
GO:0006897; Biological process: endocytosis (non-traceable author statement from UniProtKB).
GO:0001764; Biological process: neuron migration (non-traceable author statement from UniProtKB).
GO:0007416; Biological process: synaptogenesis (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR006210; EGF.
IPR000152; EGF-type_Asp/Asn_hydroxyl_CS.
IPR001438; EGF_2.
IPR000742; EGF_3.
IPR001881; EGF_Ca_bd.
IPR002049; EGF_laminin.
IPR006209; EGF_like.
IPR013032; EGF_like_reg_CS.
IPR003645; Fol_N.
Graphical view of domain structure.
Pfam PF00008; EGF; 9.
Pfam graphical view of domain structure.
PRINTS PR00010; EGFBLOOD.
PR00011; EGFLAMININ.
SMART SM00181; EGF; 7.
SM00179; EGF_CA; 3.
SM00274; FOLN; 1.
SMART graphical view of domain structure.
PROSITE PS00010; ASX_HYDROXYL; 2.
PS00022; EGF_1; 10.
PS01186; EGF_2; 7.
PS50026; EGF_3; 10.
PS01187; EGF_CA; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8NFT8.
Genome annotation databases
Ensembl ENSG00000187957; Homo sapiens. [Contig view]
GeneID 92737; -.
KEGG hsa:92737; -.
Phylogenomic databases
HOVERGEN Q8NFT8; -.
Other
NextBio 77861; -.
SOURCE DNER; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Activator; Calcium; Cell membrane; EGF-like domain; Glycoprotein; Membrane; Notch signaling pathway; Phosphoprotein; Polymorphism; Receptor; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    34  34     Potential. 
CHAIN   35   737  703     Delta and Notch-like epidermal growth factor-related receptor. PRO_0000253557
TOPO_DOM   35   640  606     Extracellular (Potential). 
TRANSMEM   641   661  21     Potential. 
TOPO_DOM   662   737  76     Cytoplasmic (Potential). 
DOMAIN   44    92  49     EGF-like 1. 
DOMAIN   94   133  40     EGF-like 2. 
DOMAIN   309   348  40     EGF-like 3. 
DOMAIN   349   390  42     EGF-like 4. 
DOMAIN   392   428  37     EGF-like 5. 
DOMAIN   430   466  37     EGF-like 6. 
DOMAIN   468   503  36     EGF-like 7. 
DOMAIN   505   541  37     EGF-like 8; calcium-binding (Potential). 
DOMAIN   543   579  37     EGF-like 9. 
DOMAIN   546   568  23     Follistatin-like. 
DOMAIN   581   617  37     EGF-like 10; calcium-binding (Potential). 
REGION   44   133  90     Interaction with NOTCH1 (By similarity). 
REGION   677   680  4     Interaction with AP1G1 and somatodendritic targeting (By similarity). 
MOD_RES   711   711        Phosphotyrosine (By similarity). 
MOD_RES   718   718        Phosphotyrosine (By similarity). 
MOD_RES   721   721        Phosphotyrosine (By similarity). 
CARBOHYD   223   223        N-linked (GlcNAc...). 
CARBOHYD   564   564        N-linked (GlcNAc...) (Potential). 
DISULFID   48    59        By similarity. 
DISULFID   53    80        By similarity. 
DISULFID   82    91        By similarity. 
DISULFID   98   108        By similarity. 
DISULFID   103   121        By similarity. 
DISULFID   123   132        By similarity. 
DISULFID   319   336        By similarity. 
DISULFID   338   347        By similarity. 
DISULFID   353   364        By similarity. 
DISULFID   358   378        By similarity. 
DISULFID   380   389        By similarity. 
DISULFID   396   407        By similarity. 
DISULFID   401   416        By similarity. 
DISULFID   418   427        By similarity. 
DISULFID   434   445        By similarity. 
DISULFID   439   454        By similarity. 
DISULFID   456   465        By similarity. 
DISULFID   472   482        By similarity. 
DISULFID   477   491        By similarity. 
DISULFID   493   502        By similarity. 
DISULFID   509   520        By similarity. 
DISULFID   514   529        By similarity. 
DISULFID   531   540        By similarity. 
DISULFID   547   558        By similarity. 
DISULFID   552   567        By similarity. 
DISULFID   569   578        By similarity. 
DISULFID   585   596        By similarity. 
DISULFID   590   605        By similarity. 
DISULFID   607   616        By similarity. 
VARIANT   433   433  1     P -> L (in dbSNP:rs17853365 [NCBI]). VAR_028380 
Sequence information
Length: 737 AA [This is the length of the unprocessed precursor] Molecular weight: 78475 Da [This is the MW of the unprocessed precursor] CRC64: 25A8A8A3044308BE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MQPRRAQAPG AQLLPALALL LLLLGAGPRG SSLANPVPAA PLSAPGPCAA QPCRNGGVCT 

        70         80         90        100        110        120 
SRPEPDPQHP APAGEPGYSC TCPAGISGAN CQLVADPCAS NPCHHGNCSS SSSSSSDGYL 

       130        140        150        160        170        180 
CICNEGYEGP NCEQALPSLP ATGWTESMAP RQLQPVPATQ EPDKILPRSQ ATVTLPTWQP 

       190        200        210        220        230        240 
KTGQKVVEMK WDQVEVIPDI ACGNASSNSS AGGRLVSFEV PQNTSVKIRQ DATASLILLW 

       250        260        270        280        290        300 
KVTATGFQQC SLIDGRSVTP LQASGGLVLL EEMLALGNNH FIGFVNDSVT KSIVALRLTL 

       310        320        330        340        350        360 
VVKVSTCVPG ESHANDLECS GKGKCTTKPS EATFSCTCEE QYVGTFCEEY DACQRKPCQN 

       370        380        390        400        410        420 
NASCIDANEK QDGSNFTCVC LPGYTGELCQ SKIDYCILDP CRNGATCISS LSGFTCQCPE 

       430        440        450        460        470        480 
GYFGSACEEK VDPCASSPCQ NNGTCYVDGV HFTCNCSPGF TGPTCAQLID FCALSPCAHG 

       490        500        510        520        530        540 
TCRSVGTSYK CLCDPGYHGL YCEEEYNECL SAPCLNAATC RDLVNGYECV CLAEYKGTHC 

       550        560        570        580        590        600 
ELYKDPCANV SCLNGATCDS DGLNGTCICA PGFTGEECDI DINECDSNPC HHGGSCLDQP 

       610        620        630        640        650        660 
NGYNCHCPHG WVGANCEIHL QWKSGHMAES LTNMPRHSLY IIIGALCVAF ILMLIILIVG 

       670        680        690        700        710        720 
ICRISRIEYQ GSSRPAYEEF YNCRSIDSEF SNAIASIRHA RFGKKSRPAM YDVSPIAYED 

       730 
YSPDDKPLVT LIKTKDL 

Q8NFT8 in FASTA format

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