ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8NFM4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name ADCY4_HUMAN
Primary accession number Q8NFM4
Secondary accession numbers Q17R40 Q96ML7
Integrated into Swiss-Prot on November 8, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 59)
Name and origin of the protein
Protein name Adenylate cyclase type 4
Synonyms EC 4.6.1.1
Adenylate cyclase type IV
ATP pyrophosphate-lyase 4
Adenylyl cyclase 4
Gene name
Name: ADCY4
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Spleen;
DOI=10.1081/RRS-120014589; PubMed=12503609 [NCBI, ExPASy, EBI, Israel, Japan]
Ludwig M.G., Seuwen K.;
"Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.";
J. Recept. Signal Transduct. Res. 22:79-110(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 541-1077.
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF497516; AAM94373.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117473; AAI17474.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117475; AAI17476.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK056745; BAB71270.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_640340.2; -.
UniGene Hs.443428
3D structure databases
HSSP P26769; 1CJK. [HSSP ENTRY / PDB]
SMR Q8NFM4; 865-1064.
ModBase Q8NFM4.
PTM databases
PhosphoSite Q8NFM4; -.
Organism-specific databases
H-InvDB HIX0011571; -.
HGNC HGNC:235; ADCY4.
GenAtlas ADCY4.
HPA CAB005070; -.
MIM 600292; gene. [NCBI / EBI]
PharmGKB PA24562; -.
GeneCards Q8NFM4.
Gene expression databases
ArrayExpress Q8NFM4; -.
CleanEx HS_ADCY4; -.
GermOnline ENSG00000129467; Homo sapiens.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0004016; Molecular function: adenylate cyclase activity (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0006171; Biological process: cAMP biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001054; A/G_cyclase.
IPR009398; Aden_cycl_like.
Graphical view of domain structure.
Gene3D G3DSA:3.30.70.1230; A/G_cyclase; 2.
Pfam PF06327; DUF1053; 1.
PF00211; Guanylate_cyc; 2.
Pfam graphical view of domain structure.
SMART SM00044; CYCc; 2.
SMART graphical view of domain structure.
PROSITE PS00452; GUANYLATE_CYCLASE_1; 2.
PS50125; GUANYLATE_CYCLASE_2; 2.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8NFM4.
Genome annotation databases
Ensembl ENSG00000129467; Homo sapiens. [Contig view]
GeneID 196883; -.
KEGG hsa:196883; -.
Phylogenomic databases
HOVERGEN Q8NFM4; -.
Other
NextBio 89574; -.
SOURCE ADCY4; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
cAMP biosynthesis; Glycoprotein; Lyase; Magnesium; Membrane; Metal-binding; Repeat; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1077  1077     Adenylate cyclase type 4. PRO_0000195690
TOPO_DOM   1     28  28     Cytoplasmic (Potential). 
TRANSMEM   29     50  22     Potential. 
TRANSMEM   61     80  20     Potential. 
TRANSMEM   94    117  24     Potential. 
TRANSMEM   120    138  19     Potential. 
TRANSMEM   141    162  22     Potential. 
TRANSMEM   170    190  21     Potential. 
TOPO_DOM   191    585  395     Cytoplasmic (Potential). 
TRANSMEM   586    607  22     Potential. 
TRANSMEM   611    633  23     Potential. 
TRANSMEM   664    687  24     Potential. 
TOPO_DOM   688    714  27     Extracellular (Potential). 
TRANSMEM   715    736  22     Potential. 
TRANSMEM   744    764  21     Potential. 
TRANSMEM   791    807  17     Potential. 
TOPO_DOM   808   1077  270     Cytoplasmic (Potential). 
METAL   278    278        Magnesium 1 (By similarity). 
METAL   278    278        Magnesium 2 (By similarity). 
METAL   279    279        Magnesium 2; via carbonyl oxygen (By similarity). 
METAL   322    322        Magnesium 1 (By similarity). 
METAL   322    322        Magnesium 2 (By similarity). 
CARBOHYD   697    697        N-linked (GlcNAc...) (Potential). 
CARBOHYD   704    704        N-linked (GlcNAc...) (Potential). 
CONFLICT   571    571        E -> G (in Ref. 3). 
Sequence information
Length: 1077 AA [This is the length of the unprocessed precursor] Molecular weight: 119794 Da [This is the MW of the unprocessed precursor] CRC64: 24C0D5AE495CFD50 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MARLFSPRPP PSEDLFYETY YSLSQQYPLL LLLLGIVLCA LAALLAVAWA SGRELTSDPS 

        70         80         90        100        110        120 
FLTTVLCALG GFSLLLGLAS REQRLQRWTR PLSGLVWVAL LALGHAFLFT GGVVSAWDQV 

       130        140        150        160        170        180 
SYFLFVIFTA YAMLPLGMRD AAVAGLASSL SHLLVLGLYL GPQPDSRPAL LPQLAANAVL 

       190        200        210        220        230        240 
FLCGNVAGVY HKALMERALR ATFREALSSL HSRRRLDTEK KHQEHLLLSI LPAYLAREMK 

       250        260        270        280        290        300 
AEIMARLQAG QGSRPESTNN FHSLYVKRHQ GVSVLYADIV GFTRLASECS PKELVLMLNE 

       310        320        330        340        350        360 
LFGKFDQIAK EHECMRIKIL GDCYYCVSGL PLSLPDHAIN CVRMGLDMCR AIRKLRAATG 

       370        380        390        400        410        420 
VDINMRVGVH SGSVLCGVIG LQKWQYDVWS HDVTLANHME AGGVPGRVHI TGATLALLAG 

       430        440        450        460        470        480 
AYAVEDAGME HRDPYLRELG EPTYLVIDPR AEEEDEKGTA GGLLSSLEGL KMRPSLLMTR 

       490        500        510        520        530        540 
YLESWGAAKP FAHLSHGDSP VSTSTPLPEK TLASFSTQWS LDRSRTPRGL DDELDTGDAK 

       550        560        570        580        590        600 
FFQVIEQLNS QKQWKQSKDF NPLTLYFREK EMEKEYRLSA IPAFKYYEAC TFLVFLSNFI 

       610        620        630        640        650        660 
IQMLVTNRPP ALAITYSITF LLFLLILFVC FSEDLMRCVL KGPKMLHWLP ALSGLVATRP 

       670        680        690        700        710        720 
GLRIALGTAT ILLVFAMAIT SLFFFPTSSD CPFQAPNVSS MISNLSWELP GSLPLISVPY 

       730        740        750        760        770        780 
SMHCCTLGFL SCSLFLHMSF ELKLLLLLLW LAASCSLFLH SHAWLSECLI VRLYLGPLDS 

       790        800        810        820        830        840 
RPGVLKEPKL MGAISFFIFF FTLLVLARQN EYYCRLDFLW KKKLRQEREE TETMENLTRL 

       850        860        870        880        890        900 
LLENVLPAHV APQFIGQNRR NEDLYHQSYE CVCVLFASVP DFKEFYSESN INHEGLECLR 

       910        920        930        940        950        960 
LLNEIIADFD ELLSKPKFSG VEKIKTIGST YMAATGLNAT SGQDAQQDAE RSCSHLGTMV 

       970        980        990       1000       1010       1020 
EFAVALGSKL DVINKHSFNN FRLRVGLNHG PVVAGVIGAQ KPQYDIWGNT VNVASRMEST 

      1030       1040       1050       1060       1070 
GVLGKIQVTE ETAWALQSLG YTCYSRGVIK VKGKGQLCTY FLNTDLTRTG PPSATLG 

Q8NFM4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!