ID   PNMA1_HUMAN             Reviewed;         353 AA.
AC   Q8ND90; O95144; Q8NG07;
DT   24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   24-OCT-2003, sequence version 2.
DT   04-NOV-2008, entry version 45.
DE   RecName: Full=Paraneoplastic antigen Ma1;
DE   AltName: Full=Neuron- and testis-specific protein 1;
DE   AltName: Full=37 kDa neuronal protein;
GN   Name=PNMA1; Synonyms=MA1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE
RP   SPECIFICITY.
RC   TISSUE=Cerebellum;
RX   MEDLINE=99158179; PubMed=10050892; DOI=10.1093/brain/122.1.27;
RA   Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T.,
RA   Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J.,
RA   Posner J.B., Rosenfeld M.R.;
RT   "Ma1, a novel neuron- and testis-specific protein, is recognized by
RT   the serum of patients with paraneoplastic neurological disorders.";
RL   Brain 122:27-39(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16214224; DOI=10.1016/j.jneuroim.2005.08.019;
RA   Schueller M., Jenne D.E., Voltz R.;
RT   "The human PNMA family: novel neuronal proteins implicated in
RT   paraneoplastic neurological disease.";
RL   J. Neuroimmunol. 169:172-176(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
RC   TISSUE=Testis;
RG   The German cDNA consortium;
RL   Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=In tumor cells, it
CC       is cytoplasmic.
CC   -!- TISSUE SPECIFICITY: Testis and brain specific. In some patients
CC       suffering from cancers, it is also specifically expressed by the
CC       paraneoplastic tumor cells.
CC   -!- MISCELLANEOUS: Antibodies against PNMA1 are present in sera from
CC       patients suffering of paraneoplastic neurological disorders.
CC   -!- SIMILARITY: Belongs to the PNMA family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF037364; AAD13810.3; -; mRNA.
DR   EMBL; AF320308; AAN05100.1; -; mRNA.
DR   EMBL; BC039577; AAH39577.1; -; mRNA.
DR   EMBL; AL834327; CAD38995.1; -; mRNA.
DR   RefSeq; NP_006020.4; -.
DR   UniGene; Hs.194709; -.
DR   IntAct; Q8ND90; -.
DR   Ensembl; ENSG00000176903; Homo sapiens.
DR   GeneID; 9240; -.
DR   KEGG; hsa:9240; -.
DR   H-InvDB; HIX0011797; -.
DR   H-InvDB; HIX0015252; -.
DR   HGNC; HGNC:9158; PNMA1.
DR   HPA; HPA003817; -.
DR   HPA; HPA015007; -.
DR   MIM; 604010; gene.
DR   PharmGKB; PA33481; -.
DR   HOGENOM; Q8ND90; -.
DR   HOVERGEN; Q8ND90; -.
DR   NextBio; 34641; -.
DR   ArrayExpress; Q8ND90; -.
DR   CleanEx; HS_PNMA1; -.
DR   GermOnline; ENSG00000176903; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; TAS:ProtInc.
DR   GO; GO:0005925; C:focal adhesion; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; TAS:ProtInc.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR   GO; GO:0007283; P:spermatogenesis; TAS:ProtInc.
PE   2: Evidence at transcript level;
KW   Nucleus; Tumor antigen.
FT   CHAIN         1    353       Paraneoplastic antigen Ma1.
FT                                /FTId=PRO_0000155199.
FT   COMPBIAS    335    341       Poly-Glu.
SQ   SEQUENCE   353 AA;  39761 MW;  EB7F5B6AEDA25961 CRC64;
     MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM LGRMFWREEN
     AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE FLERLHLFLA REGWTVQDVA
     RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ PLVESIWYKR LTLFSGRDIP GPGEETFDPW
     LEHTNEVLEE WQVSDVEKRR RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV
     ESSRDAQIKF LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH
     SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE GHF
//