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UniProtKB/Swiss-Prot entry Q8ND90


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PNMA1_HUMAN
Primary accession number Q8ND90
Secondary accession numbers O95144 Q8NG07
Integrated into Swiss-Prot on October 24, 2003
Sequence was last modified on October 24, 2003 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 44)
Name and origin of the protein
Protein name Paraneoplastic antigen Ma1
Synonyms Neuron- and testis-specific protein 1
37 kDa neuronal protein
Gene name
Name: PNMA1
Synonyms: MA1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Cerebellum;
DOI=10.1093/brain/122.1.27; PubMed=10050892 [NCBI, ExPASy, EBI, Israel, Japan]
Dalmau J., Gultekin S.H., Voltz R., Hoard R., DesChamps T., Balmaceda C., Batchelor T., Gerstner E., Eichen J., Frennier J., Posner J.B., Rosenfeld M.R.;
"Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders.";
Brain 122:27-39(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/j.jneuroim.2005.08.019; PubMed=16214224 [NCBI, ExPASy, EBI, Israel, Japan]
Schueller M., Jenne D.E., Voltz R.;
"The human PNMA family: novel neuronal proteins implicated in paraneoplastic neurological disease.";
J. Neuroimmunol. 169:172-176(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 162-353.
TISSUE=Testis;
The German cDNA consortium;
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF037364; AAD13810.3; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF320308; AAN05100.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC039577; AAH39577.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL834327; CAD38995.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_006020.4; -.
UniGene Hs.194709
3D structure databases
ModBase Q8ND90.
Protein-protein interaction databases
IntAct Q8ND90; -.
Organism-specific databases
H-InvDB HIX0011797; -.
HIX0015252; -.
HGNC HGNC:9158; PNMA1.
GenAtlas PNMA1.
HPA HPA003817; -.
HPA015007; -.
MIM 604010; gene. [NCBI / EBI]
PharmGKB PA33481; -.
GeneCards Q8ND90.
Gene expression databases
ArrayExpress Q8ND90; -.
CleanEx HS_PNMA1; -.
GermOnline ENSG00000176903; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (traceable author statement from ProtInc).
GO:0005730; Cellular component: nucleolus (traceable author statement from ProtInc).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0007417; Biological process: central nervous system development (traceable author statement from ProtInc).
GO:0007283; Biological process: spermatogenesis (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
BLOCKS Q8ND90.
Genome annotation databases
Ensembl ENSG00000176903; Homo sapiens. [Contig view]
GeneID 9240; -.
KEGG hsa:9240; -.
Phylogenomic databases
HOGENOM Q8ND90; -.
HOVERGEN Q8ND90; -.
Other
SOURCE PNMA1; Homo sapiens.
ProtoNet Q8ND90.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Nucleus; Tumor antigen.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   353  353     Paraneoplastic antigen Ma1. PRO_0000155199
COMPBIAS   335   341  7     Poly-Glu. 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 39761 Da [This is the MW of the unprocessed precursor] CRC64: EB7F5B6AEDA25961 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAMTLLEDWC RGMDVNSQRA LLVWGIPVNC DEAEIEETLQ AAMPQVSYRM LGRMFWREEN 

        70         80         90        100        110        120 
AKAALLELTG AVDYAAIPRE MPGKGGVWKV LFKPPTSDAE FLERLHLFLA REGWTVQDVA 

       130        140        150        160        170        180 
RVLGFQNPTP TPGPEMPAEM LNYILDNVIQ PLVESIWYKR LTLFSGRDIP GPGEETFDPW 

       190        200        210        220        230        240 
LEHTNEVLEE WQVSDVEKRR RLMESLRGPA ADVIRILKSN NPAITTAECL KALEQVFGSV 

       250        260        270        280        290        300 
ESSRDAQIKF LNTYQNPGEK LSAYVIRLEP LLQKVVEKGA IDKDNVNQAR LEQVIAGANH 

       310        320        330        340        350 
SGAIRRQLWL TGAGEGPAPN LFQLLVQIRE EEAKEEEEEA EATLLQLGLE GHF 

Q8ND90 in FASTA format

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