[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Retina;
DOI=10.1016/S0076-6879(00)16736-9; PubMed=10800688 [NCBI, ExPASy, EBI, Israel, Japan]
Haeseleer F.,
Palczewski K.;
"Short-chain dehydrogenases/reductases in retina.";
Methods Enzymol. 316:372-383(2000).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphoma;
DOI=10.1111/j.1365-2133.2004.05651.x; PubMed=14996095 [NCBI, ExPASy, EBI, Israel, Japan]
Hartmann T.B.,
Thiel D.,
Dummer R.,
Schadendorf D.,
Eichmueller S.;
"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma.";
Br. J. Dermatol. 150:252-258(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F.,
Gurney A.L.,
Abaya E.,
Baker K.,
Baldwin D.T.,
Brush J.,
Chen J.,
Chow B.,
Chui C.,
Crowley C.,
Currell B.,
Deuel B.,
Dowd P.,
Eaton D.,
Foster J.S.,
Grimaldi C.,
Gu Q.,
Hass P.E.,
Heldens S., ![]()
Huang A.,
Kim H.S.,
Klimowski L.,
Jin Y.,
Johnson S.,
Lee J.,
Lewis L.,
Liao D.,
Mark M.R.,
Robbie E.,
Sanchez C.,
Schoenfeld J.,
Seshagiri S.,
Simmons L.,
Singh J.,
Smith V.,
Stinson J.,
Vagts A.,
Vandlen R.L.,
Watanabe C.,
Wieand D.,
Woods K.,
Xie M.-H.,
Yansura D.G.,
Yi S.,
Yu G.,
Yuan J.,
Zhang M.,
Zhang Z.,
Goddard A.D.,
Wood W.I.,
Godowski P.J.,
Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Ota T.,
Nishikawa T.,
Suzuki Y.,
Kawai-Hio Y.,
Hayashi K.,
Ishii S.,
Saito K.,
Yamamoto J.,
Wakamatsu A.,
Nagai T.,
Nakamura Y.,
Nagahari K.,
Sugano S.,
Isogai T.;
"HRI human cDNA sequencing project.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Bone marrow, Colon, Kidney, Liver, and Urinary bladder;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[6]
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TISSUE SPECIFICITY.
PubMed=9888557 [NCBI, ExPASy, EBI, Israel, Japan]
Li K.X.Z.,
Smith R.E.,
Krozowski Z.S.;
"Cloning and expression of a novel tissue specific 17beta-hydroxysteroid dehydrogenase.";
Endocr. Res. 24:663-667(1998).
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[7]
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TISSUE SPECIFICITY.
DOI=10.1016/S0303-7207(00)00417-2; PubMed=11165019 [NCBI, ExPASy, EBI, Israel, Japan]
Brereton P.,
Suzuki T.,
Sasano H.,
Li K.,
Duarte C.,
Obeyesekere V.,
Haeseleer F.,
Palczewski K.,
Smith I.,
Komesaroff P.,
Krozowski Z.;
"Pan1b (17betaHSD11)-enzymatic activity and distribution in the lung.";
Mol. Cell. Endocrinol. 171:111-117(2001).
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[8]
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ENZYME ACTIVITY IN VITRO, AND TISSUE SPECIFICITY.
DOI=10.1210/en.2002-221030; PubMed=12697717 [NCBI, ExPASy, EBI, Israel, Japan]
Chai Z.,
Brereton P.,
Suzuki T.,
Sasano H.,
Obeyesekere V.,
Escher G.,
Saffery R.,
Fuller P.,
Enriquez C.,
Krozowski Z.;
"17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells.";
Endocrinology 144:2084-2091(2003).
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[9]
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X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 28-275.
Lukacik P.,
Bunkoczi G.,
Kavanagh K.,
Ng S.,
Von delft F.,
Bray J.,
Edwards A.,
Arrowsmith C.,
Sundstrom M.,
Oppermann U.;
"Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.";
Submitted (DEC-2004) to the PDB data bank.
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- FUNCTION: Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
- CATALYTIC ACTIVITY: Estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H.
- SUBCELLULAR LOCATION: Secreted (Potential).
- TISSUE SPECIFICITY: Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.
- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
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