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UniProtKB/Swiss-Prot entry Q8N9L9


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACOT4_HUMAN
Primary accession number Q8N9L9
Secondary accession numbers Q17RF4 Q86TX0 Q86TX1 Q96N88
Integrated into Swiss-Prot on July 19, 2004
Sequence was last modified on July 19, 2004 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 47)
Name and origin of the protein
Protein name Acyl-coenzyme A thioesterase 4
Synonyms Acyl-CoA thioesterase 4
EC 3.1.2.2
Peroxisomal acyl coenzyme A thioester hydrolase Ib
Peroxisomal long-chain acyl-CoA thioesterase Ib
PTE-Ib
PTE-2b
Gene name
Name: ACOT4
Synonyms: PTE2B, PTEIB
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cerebellum, and Kidney;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Neuroblastoma, and Placenta;
Li W.B., Gruber C., Jessee J., Polayes D.;
"Full-length cDNA libraries and normalization.";
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon, and Urinary bladder;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK094223; BAC04313.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK055797; BAB71017.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248023; CAD62346.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BX248047; CAD62354.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC031799; AAH31799.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117341; AAI17342.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC117343; AAI17344.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_689544.3; -.
UniGene Hs.49433
3D structure databases
ModBase Q8N9L9.
PTM databases
PhosphoSite Q8N9L9; -.
Organism-specific databases
HGNC HGNC:19748; ACOT4.
GenAtlas ACOT4.
HPA HPA000779; -.
PharmGKB PA142672654; -.
GeneCards Q8N9L9.
Gene expression databases
ArrayExpress Q8N9L9; -.
CleanEx HS_ACOT4; -.
GermOnline ENSG00000177465; Homo sapiens.
Ontologies
GO
GO:0005794; Cellular component: Golgi apparatus (inferred from direct assay from HPA).
GO:0005730; Cellular component: nucleolus (inferred from direct assay from HPA).
GO:0005777; Cellular component: peroxisome (inferred from direct assay from HGNC).
GO:0004091; Molecular function: carboxylesterase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0016290; Molecular function: palmitoyl-CoA hydrolase activity (inferred from electronic annotation from InterPro).
GO:0006637; Biological process: acyl-CoA metabolic process (inferred from direct assay from HGNC).
GO:0043648; Biological process: dicarboxylic acid metabolic process (inferred from direct assay from HGNC).
GO:0001676; Biological process: long-chain fatty acid metabolic process (inferred from direct assay from HGNC).
GO:0032788; Biological process: saturated monocarboxylic acid metabolic process (inferred from direct assay from HGNC).
GO:0046459; Biological process: short-chain fatty acid metabolic process (inferred from direct assay from HGNC).
GO:0006104; Biological process: succinyl-CoA metabolic process (inferred from direct assay from HGNC).
GO:0032789; Biological process: unsaturated monocarboxylic acid metabolic process (inferred from direct assay from HGNC).
GO:0000038; Biological process: very-long-chain fatty acid metabolic process (inferred from direct assay from HGNC).
QuickGo view.
Family and domain databases
InterPro IPR016662; Acyl-CoA_thioEstase_long-chain.
IPR014940; BAAT_C.
IPR006862; Thio_Ohase/aa_AcTrfase.
Graphical view of domain structure.
Pfam PF08840; BAAT_C; 1.
PF04775; Bile_Hydr_Trans; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF016521; Acyl-CoA_hydro; 1.
ProtoNet Q8N9L9.
Genome annotation databases
Ensembl ENSG00000177465; Homo sapiens. [Contig view]
GeneID 122970; -.
KEGG hsa:122970; -.
Phylogenomic databases
HOGENOM Q8N9L9; -.
HOVERGEN Q8N9L9; -.
Other
LinkHub Q8N9L9; -.
NextBio 81045; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Peroxisome; Serine esterase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   421  421     Acyl-coenzyme A thioesterase 4. PRO_0000202149
MOTIF   419   421  3     Microbody targeting signal (Potential). 
ACT_SITE   232   232        Charge relay system (By similarity). 
ACT_SITE   326   326        Charge relay system (By similarity). 
ACT_SITE   360   360        Charge relay system (By similarity). 
CONFLICT   130   130        L -> P (in Ref. 1; BAC04313). 
CONFLICT   187   190        ALAY -> DLQS (in Ref. 1; BAC04313). 
Sequence information
Length: 421 AA [This is the length of the unprocessed precursor] Molecular weight: 46327 Da [This is the MW of the unprocessed precursor] CRC64: 41BBE5AA826A9F2C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSATLILEPP GRCCWNEPVR IAVRGLAPEQ RVTLRASLRD EKGALFRAHA RYCADARGEL 

        70         80         90        100        110        120 
DLERAPALGG SFAGLEPMGL LWALEPEKPF WRFLKRDVQI PFVVELEVLD GHDPEPGRLL 

       130        140        150        160        170        180 
CQAQHERHFL PPGVRRQSVR AGRVRATLFL PPGPGPFPGI IDIFGIGGGL LEYRASLLAG 

       190        200        210        220        230        240 
HGFATLALAY YNFEDLPNNM DNISLEYFEE AVCYMLQHPQ VKGPGIGLLG ISLGADICLS 

       250        260        270        280        290        300 
MASFLKNVSA TVSINGSGIS GNTAINYKHS SIPPLGYDLR RIKVAFSGLV DIVDIRNALV 

       310        320        330        340        350        360 
GGYKNPSMIP IEKAQGPILL IVGQDDHNWR SELYAQTVSE RLQAHGKEKP QIICYPGTGH 

       370        380        390        400        410        420 
YIEPPYFPLC PASLHRLLNK HVIWGGEPRA HSKAQEDAWK QILAFFCKHL GGTQKTAVPK 


L 

Q8N9L9 in FASTA format

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