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UniProtKB/Swiss-Prot entry Q8N983


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name RM43_HUMAN
Primary accession number Q8N983
Secondary accession numbers Q5JW06 Q7Z719 Q7Z7H6 Q86XN1 Q9BYC7
Integrated into Swiss-Prot on July 19, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 46)
Name and origin of the protein
Protein name 39S ribosomal protein L43, mitochondrial [Precursor]
Synonyms L43mt
MRP-L43
Mitochondrial ribosomal protein bMRP36a
Gene name
Name: MRPL43
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4), AND SUBCELLULAR LOCATION.
DOI=10.1074/jbc.M100826200; PubMed=11279069 [NCBI, ExPASy, EBI, Israel, Japan]
Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.;
"Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria.";
J. Biol. Chem. 276:21724-21736(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature02462; PubMed=15164054 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
TISSUE=Ovary, Pancreas, Skin, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY, AND COREGULATION WITH PEO1.
DOI=10.1093/hmg/ddh342; PubMed=15509589 [NCBI, ExPASy, EBI, Israel, Japan]
Tyynismaa H., Sembongi H., Bokori-Brown M., Granycome C., Ashley N., Poulton J., Jalanko A., Spelbrink J.N., Holt I.J., Suomalainen A.;
"Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.";
Hum. Mol. Genet. 13:3219-3227(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB049656; BAB40861.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK095556; BAC04572.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL133215; CAI10919.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC015905; AAH15905.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC041165; AAH41165.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC052639; AAH52639.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC053373; AAH53373.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_789762.1; -.
NP_789763.1; -.
UniGene Hs.421848
3D structure databases
ModBase Q8N983.
Protein-protein interaction databases
IntAct Q8N983; -.
Organism-specific databases
H-InvDB HIX0009131; -.
HGNC HGNC:14517; MRPL43.
GenAtlas MRPL43.
MIM 611848; gene. [NCBI / EBI]
PharmGKB PA30975; -.
GeneCards Q8N983.
Gene expression databases
ArrayExpress Q8N983; -.
CleanEx HS_MRPL43; -.
GermOnline ENSG00000055950; Homo sapiens.
Ontologies
GO
GO:0005761; Cellular component: mitochondrial ribosome (non-traceable author statement from UniProtKB).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0003735; Molecular function: structural constituent of ribosome (non-traceable author statement from UniProtKB).
GO:0006412; Biological process: translation (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR007741; Ribos_L51_S25.
Graphical view of domain structure.
Pfam PF05047; L51_S25_CI-B8; 1.
Pfam graphical view of domain structure.
ProtoNet Q8N983.
Genome annotation databases
Ensembl ENSG00000055950; Homo sapiens. [Contig view]
GeneID 84545; -.
Phylogenomic databases
HOVERGEN Q8N983; -.
Other
NextBio 74406; -.
SOURCE MRPL43; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Mitochondrion; Ribonucleoprotein; Ribosomal protein; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   215        39S ribosomal protein L43, mitochondrial. PRO_0000030561
VAR_SEQ   156   164        DTGLRLSAV -> CLLLGAVTL (in isoform 3). VSP_011027
VAR_SEQ   156   159        DTGL -> VQAQ (in isoform 4). VSP_011029
VAR_SEQ   160   215        Missing (in isoform 4). VSP_011030
VAR_SEQ   165   215        Missing (in isoform 3). VSP_011028
VAR_SEQ   177   215        PDLPTVDPISSSLTSAPAPMLSAVSCLPIVPALTTVCSA -> ISVQSSDLPWGNTHYRPEPLSSTTWL (in isoform 2). VSP_011026
Sequence information
Length: 215 AA [This is the length of the unprocessed precursor] Molecular weight: 23431 Da [This is the MW of the unprocessed precursor] CRC64: 059C6E36FEB0D235 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTARGTPSRF LASVLHNGLG RYVQQLQRLS FSVSRDGASS RGAREFVERE VIDFARRNPG 

        70         80         90        100        110        120 
VVIYVNSRPC CVPRVVAEYL NGAVREESIH CKSVEEISTL VQKLADQSGL DVIRIRKPFH 

       130        140        150        160        170        180 
TDNPSIQGQW HPFTNKPTTF RGLRPREVQD PAPAQDTGLR LSAVAPQILL PGWPDPPDLP 

       190        200        210 
TVDPISSSLT SAPAPMLSAV SCLPIVPALT TVCSA 

Q8N983 in FASTA format

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