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UniProtKB/Swiss-Prot entry Q8N682


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DRAM_HUMAN
Primary accession number Q8N682
Secondary accession numbers Q7L3E3 Q9NUN1
Integrated into Swiss-Prot on May 15, 2007
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 41)
Name and origin of the protein
Protein name Damage-regulated autophagy modulator
Synonyms None
Gene name
Name: DRAM
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver, and Skin;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 78-238.
TISSUE=Placenta;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[3]
FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
DOI=10.1016/j.cell.2006.05.034; PubMed=16839881 [NCBI, ExPASy, EBI, Israel, Japan]
Crighton D., Wilkinson S., O'Prey J., Syed N., Smith P., Harrison P.R., Gasco M., Garrone O., Crook T., Ryan K.M.;
"DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.";
Cell 126:121-134(2006).
[4]
FUNCTION, AND INDUCTION.
DOI=10.1038/sj.cdd.4402108; PubMed=17304243 [NCBI, ExPASy, EBI, Israel, Japan]
Crighton D., O'prey J., Bell H.S., Ryan K.M.;
"p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death.";
Cell Death Differ. 14:1071-1079(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC013773; AAH13773.4; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC018435; AAH18435.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK002121; BAA92091.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00300813; -.
RefSeq NP_060840.2; -.
UniGene Hs.525634
3D structure databases
ModBase Q8N682.
Organism-specific databases
GeneCards GC12P100795; -.
MIM 610776; gene. [NCBI / EBI]
Gene expression databases
ArrayExpress Q8N682; -.
Bgee Q8N682; -.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005765; Cellular component: lysosomal membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0006915; Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0006914; Biological process: autophagy (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR019402; Frag1/DRAM/Sfk1.
Graphical view of domain structure.
Pfam PF10277; Frag1; 1.
Pfam graphical view of domain structure.
Genome annotation databases
Ensembl ENSG00000136048; Homo sapiens. [Contig view]
GeneID 55332; -.
KEGG hsa:55332; -.
Phylogenomic databases
HOGENOM Q8N682; -.
HOVERGEN Q8N682; -.
OMA Q8N682; FLTFIHD.
Other
NextBio 59626; -.
SOURCE DRAM; Homo sapiens.
ProtoNet Q8N682.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Apoptosis; Autophagy; Lysosome; Membrane; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   238  238     Damage-regulated autophagy modulator. PRO_0000287436
TRANSMEM   9    29  21     Potential. 
TRANSMEM   53    73  21     Potential. 
TRANSMEM   91   111  21     Potential. 
TRANSMEM   116   136  21     Potential. 
TRANSMEM   161   181  21     Potential. 
TRANSMEM   200   220  21     Potential. 
Sequence information
Length: 238 AA [This is the length of the unprocessed precursor] Molecular weight: 26253 Da [This is the MW of the unprocessed precursor] CRC64: 511875677737F6C0 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLCFLRGMAF VPFLLVTWSS AAFIISYVVA VLSGHVNPFL PYISDTGTTP PESGIFGFMI 

        70         80         90        100        110        120 
NFSAFLGAAT MYTRYKIVQK QNQTCYFSTP VFNLVSLVLG LVGCFGMGIV ANFQELAVPV 

       130        140        150        160        170        180 
VHDGGALLAF VCGVVYTLLQ SIISYKSCPQ WNSLSTCHIR MVISAVSCAA VIPMIVCASL 

       190        200        210        220        230 
ISITKLEWNP REKDYVYHVV SAICEWTVAF GFIFYFLTFI QDFQSVTLRI STEINGDI 

Q8N682 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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