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UniProtKB/Swiss-Prot entry Q8N1C3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GBRG1_HUMAN
Primary accession number Q8N1C3
Secondary accession numbers None
Integrated into Swiss-Prot on January 17, 2003
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 60)
Name and origin of the protein
Protein name Gamma-aminobutyric acid receptor subunit gamma-1 [Precursor]
Synonym GABA(A) receptor subunit gamma-1
Gene name
Name: GABRG1
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC031087; AAH31087.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Hs.375051
3D structure databases
ModBase Q8N1C3.
Organism-specific databases
HGNC HGNC:4086; GABRG1.
GenAtlas GABRG1.
MIM 137166; gene. [NCBI / EBI]
PharmGKB PA28500; -.
GeneCards Q8N1C3.
Gene expression databases
ArrayExpress Q8N1C3; -.
CleanEx HS_GABRG1; -.
GermOnline ENSG00000163285; Homo sapiens.
Family and domain databases
InterPro IPR006028; GABAA_rcpt.
IPR005438; GABBAg1_rcpt.
IPR005437; GABBAg_rcpt.
IPR006029; Neu_channel_TM.
IPR006202; Neur_chan_lig_bd.
IPR006201; Neur_channel.
Graphical view of domain structure.
Gene3D G3DSA:2.70.170.10; Neur_chan_lig_bd; 1.
PANTHER PTHR18945; Neur_channel; 1.
Pfam PF02931; Neur_chan_LBD; 1.
PF02932; Neur_chan_memb; 1.
Pfam graphical view of domain structure.
PRINTS PR00253; GABAARECEPTR.
PR01620; GABAARGAMMA.
PR01621; GABAARGAMMA1.
PR00252; NRIONCHANNEL.
TIGRFAMs TIGR00860; LIC; 1.
PROSITE PS00236; NEUROTR_ION_CHANNEL; 1.
BLOCKS Q8N1C3.
Genome annotation databases
Ensembl ENSG00000163285; Homo sapiens. [Contig view]
Phylogenomic databases
HOGENOM Q8N1C3; -.
HOVERGEN Q8N1C3; -.
Other
SOURCE GABRG1; Homo sapiens.
ProtoNet Q8N1C3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell junction; Cell membrane; Chloride; Chloride channel; Glycoprotein; Ion transport; Ionic channel; Lipoprotein; Membrane; Palmitate; Postsynaptic cell membrane; Signal; Synapse; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    35  35     Potential. 
CHAIN   36   465  430     Gamma-aminobutyric acid receptor subunit gamma-1. PRO_0000000473
TOPO_DOM   36   272  237     Extracellular (Probable). 
TRANSMEM   273   294  22     Probable. 
TRANSMEM   299   320  22     Probable. 
TRANSMEM   332   354  23     Probable. 
TOPO_DOM   355   444  90     Cytoplasmic (Probable). 
TRANSMEM   445   465  21     Probable. 
CARBOHYD   50    50        N-linked (GlcNAc...) (Potential). 
CARBOHYD   127   127        N-linked (GlcNAc...) (Potential). 
CARBOHYD   245   245        N-linked (GlcNAc...) (Potential). 
DISULFID   188   202        By similarity. 
Sequence information
Length: 465 AA [This is the length of the unprocessed precursor] Molecular weight: 53667 Da [This is the MW of the unprocessed precursor] CRC64: 6C314C955704F855 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGPLKAFLFS PFLLRSQSRG VRLVFLLLTL HLGNCVDKAD DEDDEDLTVN KTWVLAPKIH 

        70         80         90        100        110        120 
EGDITQILNS LLQGYDNKLR PDIGVRPTVI ETDVYVNSIG PVDPINMEYT IDIIFAQTWF 

       130        140        150        160        170        180 
DSRLKFNSTM KVLMLNSNMV GKIWIPDTFF RNSRKSDAHW ITTPNRLLRI WNDGRVLYTL 

       190        200        210        220        230        240 
RLTINAECYL QLHNFPMDEH SCPLEFSSYG YPKNEIEYKW KKPSVEVADP KYWRLYQFAF 

       250        260        270        280        290        300 
VGLRNSTEIT HTISGDYVIM TIFFDLSRRM GYFTIQTYIP CILTVVLSWV SFWINKDAVP 

       310        320        330        340        350        360 
ARTSLGITTV LTMTTLSTIA RKSLPKVSYV TAMDLFVSVC FIFVFAALME YGTLHYFTSN 

       370        380        390        400        410        420 
QKGKTATKDR KLKNKASMTP GLHPGSTLIP MNNISVPQED DYEYQCLEGK DCASFFCCFE 

       430        440        450        460 
DCRTGSWREG RIHIRIAKID SYSRIFFPTA FALFNLVYWV GYLYL
Q8N1C3 in FASTA format

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