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UniProtKB/Swiss-Prot entry Q8N0Y7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PGAM4_HUMAN
Primary accession number Q8N0Y7
Secondary accession numbers Q8NI24 Q8NI25 Q8NI26
Integrated into Swiss-Prot on November 28, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Probable phosphoglycerate mutase 4
Synonyms EC 5.4.2.1
EC 5.4.2.4
EC 3.1.3.13
Gene name
Name: PGAM4
Synonyms: PGAM3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS CYS-40; GLN-90 AND THR-175.
PubMed=11961099 [NCBI, ExPASy, EBI, Israel, Japan]
Betran E., Wang W., Jin L., Long M.;
"Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene.";
Mol. Biol. Evol. 19:654-663(2002).
[2]
ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-106, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.molcel.2006.06.026; PubMed=16916647 [NCBI, ExPASy, EBI, Israel, Japan]
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.";
Mol. Cell 23:607-618(2006).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-92; TYR-119 AND TYR-133, AND MASS SPECTROMETRY.
DOI=10.1016/j.cell.2007.11.025; PubMed=18083107 [NCBI, ExPASy, EBI, Israel, Japan]
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.";
Cell 131:1190-1203(2007).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF465731; AAM27282.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465732; AAM27283.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465733; AAM27284.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465734; AAM27285.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465735; AAM27286.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465736; AAM27287.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465737; AAM27288.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465738; AAM27289.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465739; AAM27290.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465740; AAM27291.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465741; AAM27292.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465742; AAM27293.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465743; AAM27294.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465744; AAM27295.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF465745; AAM27296.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001025062.1; -.
XP_001126103.1; -.
UniGene Hs.632822
3D structure databases
HSSP P31217; 1E58. [HSSP ENTRY / PDB]
SMR Q8N0Y7; 2-246.
ModBase Q8N0Y7.
Organism-specific databases
HGNC HGNC:21731; PGAM4.
GenAtlas PGAM4.
PharmGKB PA142671183; -.
GeneCards Q8N0Y7.
Gene expression databases
CleanEx HS_PGAM4; -.
GermOnline ENSG00000186076; Homo sapiens.
Ontologies
GO
GO:0004083; Molecular function: bisphosphoglycerate 2-phosphatase activity (inferred from electronic annotation from EC).
GO:0004082; Molecular function: bisphosphoglycerate mutase activity (inferred from electronic annotation from EC).
GO:0004619; Molecular function: phosphoglycerate mutase activity (non-traceable author statement from UniProtKB).
GO:0006096; Biological process: glycolysis (non-traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001345; PG/BPGM_mutase.
IPR013078; PG_mutase.
IPR005952; Phosphogly_mut1.
Graphical view of domain structure.
PANTHER PTHR11931; Phosphogly_mut1; 1.
Pfam PF00300; PGAM; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01258; pgm_1; 1.
PROSITE PS00175; PG_MUTASE; 1.
ProtoNet Q8N0Y7.
Genome annotation databases
Ensembl ENSG00000186076; Homo sapiens. [Contig view]
GeneID 441531; -.
728188; -.
KEGG hsa:441531; -.
hsa:728188; -.
Phylogenomic databases
HOGENOM Q8N0Y7; -.
HOVERGEN Q8N0Y7; -.
Other
LinkHub Q8N0Y7; -.
NextBio 110285; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Glycolysis; Hydrolase; Isomerase; Phosphoprotein; Polymorphism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   254  254     Probable phosphoglycerate mutase 4. PRO_0000179832
COMPBIAS   122   131  10     Pro-rich. 
ACT_SITE   11    11        Tele-phosphohistidine intermediate (By similarity). 
ACT_SITE   186   186        By similarity. 
SITE   62    62  1     Interaction with carboxyl group of phosphoglycerates (By similarity). 
MOD_RES   92    92        Phosphotyrosine. 
MOD_RES   106   106        N6-acetyllysine. 
MOD_RES   118   118        Phosphoserine. 
MOD_RES   119   119        Phosphotyrosine. 
MOD_RES   133   133        Phosphotyrosine. 
VARIANT   40    40  1     R -> C. VAR_014355 
VARIANT   90    90  1     R -> Q. VAR_014356 
VARIANT   175   175  1     I -> T. VAR_014357 
Sequence information
Length: 254 AA [This is the length of the unprocessed precursor] Molecular weight: 28777 Da [This is the MW of the unprocessed precursor] CRC64: BB589CDEAAC2E706 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAYKLVLIR HGESTWNLEN RFSCWYDADL SPAGHEEAKR GGQALRDAGY EFDICLTSVQ 

        70         80         90        100        110        120 
KRVIRTLWTV LDAIDQMWLP VVRTWRLNER HYGGLTGLNK AETAAKHGEA QVKIWRRSYD 

       130        140        150        160        170        180 
VPPPPMEPDH PFYSNISKDR RYADLTEDQL PSYESPKDTI ARALPFWNEE IVPQIKEGKR 

       190        200        210        220        230        240 
VLIAAHGNSL QGIAKHVEGL SEEAIMELNL PTGIPIVYEL DKNLKPIKPM QFLGDEETVC 

       250 
KAIEAVAAQG KAKK 

Q8N0Y7 in FASTA format

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