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UniProtKB/Swiss-Prot entry Q8N0W3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FUK_HUMAN
Primary accession number Q8N0W3
Secondary accession numbers Q5PSM3 Q5XKL6 Q6ZRA0 Q96MT9
Integrated into Swiss-Prot on November 28, 2002
Sequence was last modified on August 30, 2005 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name L-fucose kinase
Synonyms Fucokinase
EC 2.7.1.52
Gene name
Name: FUK
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
DOI=10.1016/S0006-291X(02)00541-7; PubMed=12056818 [NCBI, ExPASy, EBI, Israel, Japan]
Hinderlich S., Berger M., Blume A., Chen H., Ghaderi D., Bauer C.;
"Identification of human L-fucose kinase amino acid sequence.";
Biochem. Biophys. Res. Commun. 294:650-654(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS MET-146; THR-521; HIS-571; LEU-701; THR-858; MET-861; TRP-901; GLN-939 AND TRP-939.
SeattleSNPs program for genomic applications;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Neuron, and Thymus;
DOI=10.1038/ng1285; PubMed=14702039 [NCBI, ExPASy, EBI, Israel, Japan]
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ441184; CAD29647.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY829643; AAV67949.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK056456; BAB71190.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK128387; BAC87413.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC013735; AAH13735.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC032542; AAH32542.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JC7878; JC7878.
RefSeq NP_659496.2; -.
UniGene Hs.7907
3D structure databases
ModBase Q8N0W3.
PTM databases
PhosphoSite Q8N0W3; -.
Organism-specific databases
H-InvDB HIX0013200; -.
HGNC HGNC:29500; FUK.
GenAtlas FUK.
MIM 608675; gene. [NCBI / EBI]
PharmGKB PA134863646; -.
GeneCards Q8N0W3.
Gene expression databases
ArrayExpress Q8N0W3; -.
CleanEx HS_FUK; -.
GermOnline ENSG00000157353; Homo sapiens.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0050201; Molecular function: fucokinase activity (non-traceable author statement from UniProtKB).
GO:0016310; Biological process: phosphorylation (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR012887; Fucokinase.
IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR006206; Mev_galkinase.
Graphical view of domain structure.
Pfam PF07959; Fucokinase; 1.
PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00959; MEVGALKINASE.
PROSITE PS00627; GHMP_KINASES_ATP; FALSE_NEG.
ProtoNet Q8N0W3.
Genome annotation databases
Ensembl ENSG00000157353; Homo sapiens. [Contig view]
GeneID 197258; -.
KEGG hsa:197258; -.
NMPDR fig|9606.3.peg.12506; -.
Phylogenomic databases
HOVERGEN Q8N0W3; -.
Other
NextBio 89626; -.
SOURCE FUK; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Kinase; Nucleotide-binding; Polymorphism; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   1084  1084     L-fucose kinase. PRO_0000156672
NP_BIND   834    845  12     ATP (Potential). 
VAR_SEQ   78     78        T -> TWICVGVSLWIRGCHPPGRLPEASVHRAFPLLQ (in isoform 2). VSP_015422
VAR_SEQ   816    841        Missing (in isoform 2). VSP_015423
VARIANT   146    146  1     V -> M. VAR_021327 
VARIANT   521    521  1     A -> T (in dbSNP:rs17881069 [NCBI]). VAR_021328 
VARIANT   571    571  1     R -> H (in dbSNP:rs17886171 [NCBI]). VAR_021329 
VARIANT   701    701  1     P -> L. VAR_021330 
VARIANT   858    858  1     A -> T. VAR_021331 
VARIANT   861    861  1     V -> M. VAR_021332 
VARIANT   901    901  1     R -> W. VAR_021333 
VARIANT   939    939  1     R -> Q. VAR_021334 
VARIANT   939    939  1     R -> W. VAR_021335 
CONFLICT   400    400        L -> S (in Ref. 3; BAB71190). 
CONFLICT   609    609        C -> R (in Ref. 3; BAB71190). 
Sequence information
Length: 1084 AA [This is the length of the unprocessed precursor] Molecular weight: 117623 Da [This is the MW of the unprocessed precursor] CRC64: 153F91882F4B143C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEQPKGVDWT VIILTCQYKD SVQVFQRELE VRQKREQIPA GTLLLAVEDP EKRVGSGGAT 

        70         80         90        100        110        120 
LNALLVAAEH LSARAGFTVV TSDVLHSAWI LILHMGRDFP FDDCGRAFTC LPVENPEAPV 

       130        140        150        160        170        180 
EALVCNLDCL LDIMTYRLGP GSPPGVWVCS TDMLLSVPAN PGISWDSFRG ARVIALPGSP 

       190        200        210        220        230        240 
AYAQNHGVYL TDPQGLVLDI YYQGTEAEIQ RCVRPDGRVP LVSGVVFFSV ETAERLLATH 

       250        260        270        280        290        300 
VSPPLDACTY LGLDSGARPV QLSLFFDILH CMAENVTRED FLVGRPPELG QGDADVAGYL 

       310        320        330        340        350        360 
QSARAQLWRE LRDQPLTMAY VSSGSYSYMT SSASEFLLSL TLPGAPGAQI VHSQVEEQQL 

       370        380        390        400        410        420 
LAAGSSVVSC LLEGPVQLGP GSVLQHCHLQ GPIHIGAGCL VTGLDTAHSK ALHGRELRDL 

       430        440        450        460        470        480 
VLQGHHTRLH GSPGHAFTLV GRLDSWERQG AGTYLNVPWS EFFKRTGVRA WDLWDPETLP 

       490        500        510        520        530        540 
AEYCLPSARL FPVLHPSREL GPQDLLWMLD HQEDGGEALR AWRASWRLSW EQLQPCLDRA 

       550        560        570        580        590        600 
ATLASRRDLF FRQALHKARH VLEARQDLSL RPLIWAAVRE GCPGPLLATL DQVAAGAGDP 

       610        620        630        640        650        660 
GVAARALACV ADVLGCMAEG RGGLRSGPAA NPEWMRPFSY LECGDLAAGV EALAQERDKW 

       670        680        690        700        710        720 
LSRPALLVRA ARHYEGAGQI LIRQAVMSAQ HFVSTEQVEL PGPGQWVVAE CPARVDFSGG 

       730        740        750        760        770        780 
WSDTPPLAYE LGGAVLGLAV RVDGRRPIGA RARRIPEPEL WLAVGPRQDE MTVKIVCRCL 

       790        800        810        820        830        840 
ADLRDYCQPH APGALLKAAF ICAGIVHVHS ELQLSEQLLR TFGGGFELHT WSELPHGSGL 

       850        860        870        880        890        900 
GTSSILAGTA LAALQRAAGR VVGTEALIHA VLHLEQVLTT GGGWQDQVGG LMPGIKVGRS 

       910        920        930        940        950        960 
RAQLPLKVEV EEVTVPEGFV QKLNDHLLLV YTGKTRLARN LLQDVLRSWY ARLPAVVQNA 

       970        980        990       1000       1010       1020 
HSLVRQTEEC AEGFRQGSLP LLGQCLTSYW EQKKLMAPGC EPLTVRRMMD VLAPHVHGQS 

      1030       1040       1050       1060       1070       1080 
LAGAGGGGFL YLLTKEPQQK EALEAVLAKT EGLGNYSIHL VEVDTQGLSL KLLGTEASTC 


CPFP 

Q8N0W3 in FASTA format

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