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UniProtKB/Swiss-Prot entry Q8MNZ1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GP63_LEITR
Primary accession number Q8MNZ1
Secondary accession number Q8MNZ0
Integrated into Swiss-Prot on August 16, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 30)
Name and origin of the protein
Protein name Leishmanolysin [Precursor]
Synonyms EC 3.4.24.36
Cell surface protease
Major surface glycoprotein
Protein gp63
Promastigote surface endopeptidase
Major surface protease
Gene name
Name: mspC
From
Leishmania tropica [TaxID: 5666] 
Taxonomy Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmania.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELES MSPCLTA1 AND MSPCLTA2).
STRAIN=MHOM/SU/1974/K27;
Mauricio I.L., Stothard J.R., Miles M.A.;
"Genetic diversity in the Leishmania donovani complex.";
Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ495008; CAD42817.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ495009; CAD42818.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P08148; 1LML. [HSSP ENTRY / PDB]
SMR Q8MNZ1; 102-577.
ModBase Q8MNZ1.
Protein family/group databases
MEROPS M08.001; -.
Ontologies
GO
GO:0016020; Cellular component: membrane (inferred from electronic annotation from InterPro).
GO:0004222; Molecular function: metalloendopeptidase activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from UniProtKB-KW).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0007155; Biological process: cell adhesion (inferred from electronic annotation from InterPro).
GO:0006508; Biological process: proteolysis (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR006025; Pept_M_Zn_BS.
IPR001577; Peptidase_M8.
Graphical view of domain structure.
PANTHER PTHR10942; Peptidase_M8; 1.
Pfam PF01457; Peptidase_M8; 1.
Pfam graphical view of domain structure.
PRINTS PR00782; LSHMANOLYSIN.
PROSITE PS00142; ZINC_PROTEASE; 1.
ProtoNet Q8MNZ1.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell adhesion; Glycoprotein; Hydrolase; Metal-binding; Metalloprotease; Polymorphism; Protease; Signal; Zinc; Zymogen.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    41  41     Potential. 
PROPEP   42   102  61     Activation peptide (Potential). PRO_0000028672
CHAIN   103   657  555     Leishmanolysin. PRO_0000028673
ACT_SITE   267   267        By similarity. 
METAL   266   266        Zinc; catalytic (By similarity). 
METAL   270   270        Zinc; catalytic (By similarity). 
METAL   336   336        Zinc; catalytic (By similarity). 
CARBOHYD   107   107        N-linked (GlcNAc...) (Potential). 
CARBOHYD   302   302        N-linked (GlcNAc...) (Potential). 
CARBOHYD   399   399        N-linked (GlcNAc...) (Potential). 
CARBOHYD   409   409        N-linked (GlcNAc...) (Potential). 
CARBOHYD   445   445        N-linked (GlcNAc...) (Potential). 
CARBOHYD   466   466        N-linked (GlcNAc...) (Potential). 
CARBOHYD   501   501        N-linked (GlcNAc...) (Potential). 
DISULFID   127   144        By similarity. 
DISULFID   193   232        By similarity. 
DISULFID   316   388        By similarity. 
DISULFID   395   458        By similarity. 
DISULFID   408   427        By similarity. 
DISULFID   417   492        By similarity. 
DISULFID   469   513        By similarity. 
DISULFID   518   568        By similarity. 
DISULFID   538   561        By similarity. 
VARIANT   596   611  16     Missing (in allele mspCLtA2). 
Sequence information
Length: 657 AA [This is the length of the unprocessed precursor] Molecular weight: 70343 Da [This is the MW of the unprocessed precursor] CRC64: 83FBC04757887E51 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSVDSSSSST HRRRCVAARL VRLAAAGAAV TVAVGTAAAW AHAGALQHRC IHDAMQARVR 

        70         80         90        100        110        120 
QSVARHHTAP GAVSAVGLPY VTLDAAHTAA AADPRPGSAP TVVRAANWST LRVAVSTEDL 

       130        140        150        160        170        180 
TDPAYHCARV GQRVNNHAGA IVTCTAEDIL TDEKRDILRK YLIPQALQLH TERLKARQVQ 

       190        200        210        220        230        240 
GKWKVTGMVD EICGDFKVPQ AHITEGFSNT DFVMYVASVP SEEGVLAWAT TCQVFSDGHP 

       250        260        270        280        290        300 
AVGVINIPAA NIASRYDQLV TRVVTHEMAH ALGFSEEFFT AARIVAHVSN VRHKTLKVPV 

       310        320        330        340        350        360 
VNSSTAVAKA REQYGCGTLE YLEIEDQGGA GSAGSHIKMR NAQDELMAPA AAGGYYTALT 

       370        380        390        400        410        420 
MAVFQDLGFY QADFNKAKVM PWGRNAGCAF LSEKCMEQNI TKWRAMFCNE SEDVMRCPTS 

       430        440        450        460        470        480 
RLSLGTCGIR GYRPPLPRYW QYFTNASLGG YSPFMDYCPV VIGYANGSCN QDASSAAEFL 

       490        500        510        520        530        540 
AAFNVFSEAA RCIDGAFTPK NRTAADGYYA GLCANVRCDT ATRTYSVQVR GSMDYVSCTP 

       550        560        570        580        590        600 
GLRVELSTVS NAFEEGGCIT CPPYVEVCQG NVKGAKDFAG DSDSSSSADD AAGKAAMLRW 

       610        620        630        640        650 
NDRMVGLATA ATVLLGMVLS LMALVVVWLL LVSCPWWCCK LGGPPASVTP ACSPETE
Q8MNZ1 in FASTA format

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