[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=DM4; PubMed=12055310 [NCBI, ExPASy, EBI, Israel, Japan] Kayser M.F., Ucurum Z., Vuilleumier S.; "Dichloromethane metabolism and C1 utilization genes in Methylobacterium strains."; Microbiology 148:1915-1922(2002).

Comments

FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl-H(4)MPT (By similarity).
CATALYTIC ACTIVITY: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H₂O = 5-formyl-5,6,7,8-tetrahydromethanopterin.
PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (H(4)MPT route): step 3/5 .
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the MCH family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ421477; CAD13315.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P94954; 1QLM. [HSSP ENTRY / PDB]

ModBase

Q8KMJ5.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0018759;	Molecular function: methenyltetrahydromethanopterin cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0006730;	Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00486; -; 1.
PBIL [Tree]

InterPro

IPR003209; METHMP_CycOHase.
Graphical view of domain structure.

Pfam

PF02289; MCH; 1.
Pfam graphical view of domain structure.

ProDom

PD011637; Cyclohydrolase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR03120; one_C_mch; 1.

ProtoNet

Q8KMJ5.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Hydrolase; One-carbon metabolism.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 323`	`323`		`Methenyltetrahydromethanopterin cyclohydrolase.`	`PRO_0000140894`

Sequence information

Length: 323 AA [This is the length of the unprocessed precursor]

Molecular weight: 33268 Da [This is the MW of the unprocessed precursor]

CRC64: 900FF2379E84F531 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSNTSAPSL NALAGPLVES LVADAAKLRL IVAQENGART VDAGANARGS IEAGRRIAEI 

        70         80         90        100        110        120 
CLGGLGTVTI APIGPVASWP YTVVVHSADP VLACLGSQYA GWSLADEDGD SGFFALGSGP 

       130        140        150        160        170        180 
GRAVAVVEEL YKELGYRDNA TTTALVLESG SAPPASVVNK VAAATGLAPE NVTFIYAPTQ 

       190        200        210        220        230        240 
SLAGSTQVVA RVLEVALHKA HTVGFDLHKI LDGIGSAPLS PPHPDFIQAM GRTNDAIIYG 

       250        260        270        280        290        300 
GRVQLFVDAD DADAKQLAEQ IPSTTSADHG APFAEIFSRV NGDFYKIDGA LFSPAEAIVT 

       310        320 
SVKTGKSFRG GRLEPQLVDA SFV

Q8KMJ5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools