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UniProtKB/Swiss-Prot entry Q8KEG8

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SAHH_CHLTE
Primary accession number Q8KEG8
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 44)
Name and origin of the protein
Protein name Adenosylhomocysteinase
Synonyms EC 3.3.1.1
S-adenosyl-L-homocysteine hydrolase
AdoHcyase
Gene name
Name: ahcY
Synonyms: sahH
OrderedLocusNames: CT0721
From
Chlorobium tepidum [TaxID: 1097] [HAMAP proteome]
Taxonomy Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / TLS;
DOI=10.1073/pnas.132181499; PubMed=12093901 [NCBI, ExPASy, EBI, Israel, Japan]
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006470; AAM71958.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_661616.1; -.
3D structure databases
HSSP P10760; 1B3R. [HSSP ENTRY / PDB]
ModBase Q8KEG8.
Enzyme and pathway databases
BioCyc CTEP194439:CT_0721-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004013; Molecular function: adenosylhomocysteinase activity (inferred from electronic annotation from HAMAP).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0006730; Biological process: one-carbon compound metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00563; -; 1.
PBIL [Tree]
InterPro IPR000043; Ad_hcy_hydrolase.
IPR015878; Ado_hCys_hydrolase_NAD-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.1480; Ad_hcy_hydrolase; 1.
PANTHER PTHR23420; Ad_hcy_hydrolase; 1.
Pfam PF05221; AdoHcyase; 1.
PF00670; AdoHcyase_NAD; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001109; Ad_hcy_hydrolase; 1.
TIGRFAMs TIGR00936; ahcY; 1.
PROSITE PS00738; ADOHCYASE_1; 1.
PS00739; ADOHCYASE_2; 1.
ProtoNet Q8KEG8.
Genome annotation databases
GeneID 1006351; -.
GenomeReviews AE006470_GR; CT0721.
KEGG cte:CT0721; -.
NMPDR fig|194439.1.peg.710; -.
TIGR CT0721; -.
Phylogenomic databases
HOGENOM Q8KEG8; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Hydrolase; NAD; One-carbon metabolism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   471  471     Adenosylhomocysteinase. PRO_0000116956
REGION   223   391  169     NAD binding (By similarity). 
BINDING   60    60        Substrate (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   196   196        Substrate (By similarity). 
BINDING   226   226        Substrate (By similarity). 
BINDING   230   230        Substrate (By similarity). 
Sequence information
Length: 471 AA [This is the length of the unprocessed precursor] Molecular weight: 51949 Da [This is the MW of the unprocessed precursor] CRC64: 31B082405D241047 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTTEAAVLDY KVADISLAEW GRKEIEIAEK EMPGLMATRK KYEGKKPLAG ARIAGSLHMT 

        70         80         90        100        110        120 
IQTAVLIETL VELGADVRWA SCNIFSTQDH AAAAIAAAGV PVFAWKGETL DEYWWCTRQI 

       130        140        150        160        170        180 
LEFEGGLGPN LIVDDGGDAT LMIHFGYKIE NDPSMLDKTP GNAEEKALLQ QLKAVFAEDN 

       190        200        210        220        230        240 
QRWHKVAAGM KGVSEETTTG VHRLYQMMEK GELLFPAINV NDSVTKSKFD NLYGCRESLA 

       250        260        270        280        290        300 
DGIKRATDVM IAGKVVVVLG YGDVGKGCAH SMRSYGARVI VTEIDPICAL QAAMEGFEVT 

       310        320        330        340        350        360 
TMEEAVKEGN IFVTATGNKD VITLDHIKQM RDEAIVCNIG HFDNEIQVDA LNNFKGATRI 

       370        380        390        400        410        420 
NIKPQVDKYV FENGNCIYLL AEGRLVNLGC ATGHPSFVMS NSFTNQTLAQ IELWQNDYKV 

       430        440        450        460        470 
GVYRLPKKLD EEVARLHLGQ IGAKLTTLTK EQADYIGVPV EGPYKPEHYR Y
Q8KEG8 in FASTA format

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