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UniProtKB/Swiss-Prot entry Q8KDK5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYRC_CHLTE
Primary accession number Q8KDK5
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 2003
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 43)
Name and origin of the protein
Protein name Dihydroorotase
Synonyms DHOase
EC 3.5.2.3
Gene name
Name: pyrC
OrderedLocusNames: CT1042
From
Chlorobium tepidum [TaxID: 1097] [HAMAP proteome]
Taxonomy Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / TLS;
DOI=10.1073/pnas.132181499; PubMed=12093901 [NCBI, ExPASy, EBI, Israel, Japan]
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006470; AAM72275.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_661933.1; -.
3D structure databases
ModBase Q8KDK5.
Enzyme and pathway databases
BioCyc CTEP194439:CT_1042-MON; -.
Ontologies
GO
GO:0004151; Molecular function: dihydroorotase activity (inferred from electronic annotation from HAMAP).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from HAMAP).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00220; -; 1.
PBIL [Tree]
InterPro IPR006680; Amidohydro_1.
IPR004722; DHOmult.
IPR002195; Dihydroorotase_CS.
Graphical view of domain structure.
Pfam PF01979; Amidohydro_1; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00857; pyrC_multi; 1.
PROSITE PS00482; DIHYDROOROTASE_1; FALSE_NEG.
PS00483; DIHYDROOROTASE_2; 1.
ProtoNet Q8KDK5.
Genome annotation databases
GeneID 1006973; -.
GenomeReviews AE006470_GR; CT1042.
KEGG cte:CT1042; -.
NMPDR fig|194439.1.peg.1027; -.
TIGR CT1042; -.
Phylogenomic databases
HOGENOM Q8KDK5; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Hydrolase; Metal-binding; Pyrimidine biosynthesis; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   439  439     Dihydroorotase. PRO_0000147230
METAL   65    65        Zinc 1 (By similarity). 
METAL   67    67        Zinc 1 (By similarity). 
METAL   183   183        Zinc 2 (By similarity). 
METAL   246   246        Zinc 2 (By similarity). 
METAL   321   321        Zinc 1 (By similarity). 
Sequence information
Length: 439 AA [This is the length of the unprocessed precursor] Molecular weight: 47039 Da [This is the MW of the unprocessed precursor] CRC64: 71FDCBCA995B7183 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTLFLNARL LNPAENLDTV GSIKIGDDGL IEAVATGGES IPAKAEDNVI DLAGKVLAPG 

        70         80         90        100        110        120 
LFDMHCHFRE PGQEYKETLE TGSAAAVAGG FTGVALMPNT RPVIDSPLGV AYIRHHSAGL 

       130        140        150        160        170        180 
PIDLEVIGAM TVESRGEALA PYGKYASYSV KAVSDDGTAI QSSQIMRLAI EYAANFDLLL 

       190        200        210        220        230        240 
IQHAEDKHLT AGGIMNDGAV SAMLGLKGIP EVAEPIMIAR DLQLIAWLKK HKLNGAVAEP 

       250        260        270        280        290        300 
RYHVAHISTA ESVALVRKAK AAGLKVTCEV TPHHFTLTEH DLSSSIEKGN FIMKPPLASV 

       310        320        330        340        350        360 
ENRDALIEGL RDGTIDAIAT DHAPHAKHEK ECPPDQAAFG IIGLETSLGL TITELVDKGV 

       370        380        390        400        410        420 
ITLSQAIELL STNPRRIMGL ETILFRAGRK ANLTIIDPDC EWIVSESDFG SKSRNTPFMG 

       430 
RKLKGRALGI YHNSKLIMR
Q8KDK5 in FASTA format

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