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UniProtKB/Swiss-Prot entry Q8KAW7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name KHSE_CHLTE
Primary accession number Q8KAW7
Secondary accession numbers None
Integrated into Swiss-Prot on February 15, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 39)
Name and origin of the protein
Protein name Homoserine kinase
Synonyms HSK
HK
EC 2.7.1.39
Gene name
Name: thrB
OrderedLocusNames: CT2034
From
Chlorobium tepidum [TaxID: 1097] [HAMAP proteome]
Taxonomy Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 49652 / DSM 12025 / TLS;
DOI=10.1073/pnas.132181499; PubMed=12093901 [NCBI, ExPASy, EBI, Israel, Japan]
Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium.";
Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE006470; AAM73251.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_662909.1; -.
3D structure databases
HSSP Q58504; 1H74. [HSSP ENTRY / PDB]
ModBase Q8KAW7.
Enzyme and pathway databases
BioCyc CTEP194439:CT_2034-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0004413; Molecular function: homoserine kinase activity (inferred from electronic annotation from HAMAP).
GO:0016310; Biological process: phosphorylation (inferred from electronic annotation from InterPro).
GO:0009088; Biological process: threonine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00384; -; 1.
PBIL [Tree]
InterPro IPR006204; GHMP_kinase.
IPR013750; GHMP_kinase_C.
IPR006203; GHMP_knse_ATP_bd_CS.
IPR000870; Homoser_kin.
IPR014721; Ribosomal_S5_D2-type_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
Pfam PF08544; GHMP_kinases_C; 1.
PF00288; GHMP_kinases_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000676; Homoser_kin; 1.
PRINTS PR00958; HOMSERKINASE.
TIGRFAMs TIGR00191; thrB; 1.
PROSITE PS00627; GHMP_KINASES_ATP; 1.
ProtoNet Q8KAW7.
Genome annotation databases
GeneID 1007526; -.
GenomeReviews AE006470_GR; CT2034.
KEGG cte:CT2034; -.
NMPDR fig|194439.1.peg.2003; -.
TIGR CT2034; -.
Phylogenomic databases
HOGENOM Q8KAW7; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Threonine biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   324  324     Homoserine kinase. PRO_0000156560
NP_BIND   100   110  11     ATP (Potential). 
Sequence information
Length: 324 AA [This is the length of the unprocessed precursor] Molecular weight: 33771 Da [This is the MW of the unprocessed precursor] CRC64: DA228CBDC45330DE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTVTGFASA TVGNVACGFD VLGFAITEPG DEVVLALHDE RRSDCPVSIT SIVGDGGALP 

        70         80         90        100        110        120 
LDPKKNTSSF VVLKFLEYIR TTKGISFDGH IDLVLKKNLP LSSGMGSSAA SAAAALIAAN 

       130        140        150        160        170        180 
ELFGSPCTKM ELVHFAIEGE RVACGSAHAD NAAPAMLGNF ILIRSYNPLD LITIKPPKNL 

       190        200        210        220        230        240 
FGTLVHPHTE LKTSFARSVL PKSIPLSTAT QQWGNVGALI AGLLMEDYDL IGRALVDVVA 

       250        260        270        280        290        300 
EPKRAPLIPG FNEVKQAALD AGALGCSIAG SGPSVFAFSS SRQTAEAVGS AMQSAFLHSR 

       310        320 
AALQSDMWVS PICSQGARII STTS
Q8KAW7 in FASTA format

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