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UniProtKB/Swiss-Prot entry Q8K9U7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PANC_BUCAP
Primary accession number Q8K9U7
Secondary accession numbers None
Integrated into Swiss-Prot on November 15, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 37)
Name and origin of the protein
Protein name Pantothenate synthetase
Synonyms PS
EC 6.3.2.1
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene name
Name: panC
OrderedLocusNames: BUsg_190
From
Buchnera aphidicola subsp. Schizaphis graminum [TaxID: 98794] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1071278; PubMed=12089438 [NCBI, ExPASy, EBI, Israel, Japan]
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
"50 million years of genomic stasis in endosymbiotic bacteria.";
Science 296:2376-2379(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE013218; AAM67755.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_660544.1; -.
3D structure databases
HSSP P31663; 1IHO. [HSSP ENTRY / PDB]
ModBase Q8K9U7.
Enzyme and pathway databases
BioCyc BAPH198804:BUSG190-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004592; Molecular function: pantoate-beta-alanine ligase activity (inferred from electronic annotation from HAMAP).
GO:0015940; Biological process: pantothenate biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00158; -; 1.
PBIL [Tree]
InterPro IPR003721; Pantoate_ligase.
IPR014729; Rossmann-like_a/b/a_fold.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.620; Rossmann-like_a/b/a_fold; 1.
PANTHER PTHR21299:SF1; Pantoate_ligase; 1.
Pfam PF02569; Pantoate_ligase; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00018; panC; 1.
ProtoNet Q8K9U7.
Genome annotation databases
GeneID 1005387; -.
GenomeReviews AE013218_GR; BUsg_190.
KEGG bas:BUsg190; -.
Phylogenomic databases
HOGENOM Q8K9U7; -.
Genome annotation databases
CMR Q8K9U7; BUsg_190.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding; Pantothenate biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   285  285     Pantothenate synthetase. PRO_0000128213
NP_BIND   30    37  8     ATP (By similarity). 
NP_BIND   149   152  4     ATP (By similarity). 
NP_BIND   186   189  4     ATP (By similarity). 
ACT_SITE   37    37        Proton donor (By similarity). 
BINDING   61    61        Beta-alanine (By similarity). 
BINDING   61    61        Pantoate (By similarity). 
BINDING   155   155        Pantoate (By similarity). 
BINDING   178   178        ATP; via amide nitrogen and carbonyl oxygen (By similarity). 
Sequence information
Length: 285 AA [This is the length of the unprocessed precursor] Molecular weight: 32965 Da [This is the MW of the unprocessed precursor] CRC64: 28DEE9F09FE84B53 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNIIKNINLL EKKIKELKKK NKIIGLVPTM GNLHDGHIKL ILLAKKNVDI VIVSIFINPM 

        70         80         90        100        110        120 
QFEDLLDLKK YPKTFEQDCC ILKQEKVEIL FCPDVNEMYP LGLKNHTYID VPKLSKIIEG 

       130        140        150        160        170        180 
KVRPGHFIGV TTIVCKLFNL IQPNFSFFGE KDYQQLLIIK KLVKELNYPI KIISLPIIRL 

       190        200        210        220        230        240 
KNGLAFSSRN KHLSDLAQQK ASYLYQAIKQ TCNFIKNNNG KNIKKNIHTS RKYLIKKGFY 

       250        260        270        280 
IDIFNAYDSK TLDPISKDSK NIIIIASVWL GKIRLIDNKK IILRD
Q8K9U7 in FASTA format

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