ID   G6PD_BUCAP              Reviewed;         490 AA.
AC   Q8K9M2;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-NOV-2008, entry version 46.
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf; OrderedLocusNames=BUsg_312;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: D-glucose 6-phosphate + NADP(+) = D-glucono-
CC       1,5-lactone 6-phosphate + NADPH.
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage):
CC       step 1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase
CC       family.
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DR   EMBL; AE013218; AAM67866.1; -; Genomic_DNA.
DR   RefSeq; NP_660655.1; -.
DR   HSSP; P11411; 1DPG.
DR   GeneID; 1005516; -.
DR   GenomeReviews; AE013218_GR; BUsg_312.
DR   KEGG; bas:BUsg312; -.
DR   HOGENOM; Q8K9M2; -.
DR   BioCyc; BAPH198804:BUSG312-MON; -.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001282; Glc-6-P_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR23429; G6PDH; 1.
DR   Pfam; PF02781; G6PD_C; 1.
DR   Pfam; PF00479; G6PD_N; 1.
DR   PIRSF; PIRSF000110; G6PD; 1.
DR   PRINTS; PR00079; G6PDHDRGNASE.
DR   ProDom; PD001129; G6PD; 1.
DR   TIGRFAMs; TIGR00871; zwf; 1.
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    490       Glucose-6-phosphate 1-dehydrogenase.
FT                                /FTId=PRO_0000068113.
FT   ACT_SITE    238    238       Proton acceptor (By similarity).
FT   BINDING      17     17       NADP (By similarity).
FT   BINDING      49     49       NADP (By similarity).
FT   BINDING     176    176       Substrate (By similarity).
FT   BINDING     180    180       Substrate (By similarity).
FT   BINDING     343    343       Substrate (By similarity).
SQ   SEQUENCE   490 AA;  57531 MW;  8554072078E042D9 CRC64;
     MIIETNQACD LVIFGTKGDL ARRKLLPALY KLEKSQKIHP DTRIIGTGRA DWNTEDYIKI
     VKKAIKMFLN EKIDEKIWKK LRSRLNFFYI DVFQDLHFLE LKNILNQKKN IIIYYCAVPS
     NTFNAIFTGL GKVNLNSFPS RIIIEKPLGV SLETSKKINN QIAKYFLESQ IFRIDHYLGK
     ESILNLLALR FSNSFFFHSW NNKIIDHIQI TVSEEVGIEN RWNYFDQMGQ TRDMVQNHLL
     QILTIVSMDK PKNITPEGIR DEKLKILRSL KKIDLNEIHI KTARGQYASG IINGKKVPSY
     IEENGANKHS KTETFVSIKV DINNDRWFGV PFYLRTGKRL AYKYSEIVIV FKKISKNLFQ
     EFNKNLSPNK LIIRLEPNES IKIYFLNKVP GLSKEYKLKS DKMEFNFNIN NTKNFVDAYE
     RLLFESMRGI QSLFVCREEV EEAWKWIDPI INGWKKTNIN TVQLYKSGTW GPKSSDEIIM
     RDGRFWETFN
//