ID   PYRB_BUCAP              Reviewed;         311 AA.
AC   Q8K9H9;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-NOV-2008, entry version 44.
DE   RecName: Full=Aspartate carbamoyltransferase;
DE            EC=2.1.3.2;
DE   AltName: Full=Aspartate transcarbamylase;
DE            Short=ATCase;
GN   Name=pyrB; OrderedLocusNames=BUsg_357;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: Carbamoyl phosphate + L-aspartate = phosphate
CC       + N-carbamoyl-L-aspartate.
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo
CC       pathway; UMP from HCO(3)(-): step 2/6.
CC   -!- SIMILARITY: Belongs to the ATCase/OTCase family.
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DR   EMBL; AE013218; AAM67910.1; -; Genomic_DNA.
DR   RefSeq; NP_660699.1; -.
DR   HSSP; P00479; 1GQ3.
DR   GeneID; 1005798; -.
DR   GenomeReviews; AE013218_GR; BUsg_357.
DR   KEGG; bas:BUsg357; -.
DR   HOGENOM; Q8K9H9; -.
DR   BioCyc; BAPH198804:BUSG357-MON; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:HAMAP.
DR   GO; GO:0006207; P:'de novo' pyrimidine base biosynthetic process; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00001; -; 1.
DR   InterPro; IPR006130; Asp/Orn_carbamoyltranf.
DR   InterPro; IPR006132; Asp/Orn_carbamoyltranf_P_bd.
DR   InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
DR   InterPro; IPR002082; Aspartate_carbamoyltransf_euk.
DR   Pfam; PF00185; OTCace; 1.
DR   Pfam; PF02729; OTCace_N; 1.
DR   PRINTS; PR00100; AOTCASE.
DR   PRINTS; PR00101; ATCASE.
DR   TIGRFAMs; TIGR00670; asp_carb_tr; 1.
DR   PROSITE; PS00097; CARBAMOYLTRANSFERASE; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Pyrimidine biosynthesis; Transferase.
FT   CHAIN         1    311       Aspartate carbamoyltransferase.
FT                                /FTId=PRO_0000113111.
SQ   SEQUENCE   311 AA;  35315 MW;  4225C7BDDE2C11BD CRC64;
     MRNSLYKKNI ISISDLNQNE LELVLKKSAF LKVKAQPNLL KNKIIASCFF EASTRTRLSF
     ETAVHRLGAS IIGFSDGSNI SLGKKGETLS DTISVISSYV DAIIIRHPQE GSARLAAQFS
     NGVPIFNAGD GANQHPTQTL LDLFTIKETQ NKLNNLNIAM VGDLKYGRTV HSLTQALAKY
     KNNQFFFVSP DSLTMPNYIN DMLYKKEIHW KRYKNIEEII SEIDILYMTR VQKERLDSTE
     YASAKSKFVL QTSTLKNARN NLKILHPLPR IDEIDNNVDF TPYAWYFKQA ANGIYARQAI
     LSLVLIEKHF E
//