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UniProtKB/Swiss-Prot entry Q8K9C3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name TYSY_BUCAP
Primary accession number Q8K9C3
Secondary accession numbers None
Integrated into Swiss-Prot on November 15, 2002
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 42)
Name and origin of the protein
Protein name Thymidylate synthase
Synonyms TS
TSase
EC 2.1.1.45
Gene name
Name: thyA
OrderedLocusNames: BUsg_425
From
Buchnera aphidicola subsp. Schizaphis graminum [TaxID: 98794] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Buchnera.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1126/science.1071278; PubMed=12089438 [NCBI, ExPASy, EBI, Israel, Japan]
Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S., Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
"50 million years of genomic stasis in endosymbiotic bacteria.";
Science 296:2376-2379(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE013218; AAM67968.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_660757.1; -.
3D structure databases
HSSP P00470; 1F4G. [HSSP ENTRY / PDB]
ModBase Q8K9C3.
Enzyme and pathway databases
BioCyc BAPH198804:BUSG425-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004799; Molecular function: thymidylate synthase activity (inferred from electronic annotation from HAMAP).
GO:0006231; Biological process: dTMP biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00008; -; 1.
PBIL [Tree]
InterPro IPR000398; Thymidylat_synth_C.
Graphical view of domain structure.
Gene3D G3DSA:3.30.572.10; Thymidylat_synth_C; 1.
PANTHER PTHR11549:SF2; Thymidylat_synth_C; 1.
Pfam PF00303; Thymidylat_synt; 1.
Pfam graphical view of domain structure.
PRINTS PR00108; THYMDSNTHASE.
ProDom PD001180; Thymidylat_synth; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR03284; thym_sym; 1.
PROSITE PS00091; THYMIDYLATE_SYNTHASE; 1.
ProtoNet Q8K9C3.
Genome annotation databases
GeneID 1005738; -.
GenomeReviews AE013218_GR; BUsg_425.
KEGG bas:BUsg425; -.
Phylogenomic databases
HOGENOM Q8K9C3; -.
Genome annotation databases
CMR Q8K9C3; BUsg_425.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Methyltransferase; Nucleotide biosynthesis; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   264  264     Thymidylate synthase. PRO_0000140945
ACT_SITE   146   146        By similarity. 
Sequence information
Length: 264 AA [This is the length of the unprocessed precursor] Molecular weight: 30716 Da [This is the MW of the unprocessed precursor] CRC64: 355E01002E2BF15A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKQYLDLIKK IIKNGNSKKD RTGTGTLSIF GHHMKFDLKK GFPLITTKKC HIPSIIHELL 

        70         80         90        100        110        120 
WFLRGETNIK YLNENKISIW DNWADKFGDL GPIYGKQWRS WDTSNGKKID QIKNVLKQIK 

       130        140        150        160        170        180 
EDPDSRRILV SSWNVGEIDK MSLAPCHILF QFYVLKKKLS CQLYQRSCDV FLGLPFNIAS 

       190        200        210        220        230        240 
YAILIHMIAQ QCNLQVGEFL WTGGDVHLYK NHVELAKKQI LRIPKKLPEL IILKKPQSLF 

       250        260 
QYSFEDFKIV GYKPYSLIKG KISV
Q8K9C3 in FASTA format

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