ID   MTLD_BUCAP              Reviewed;         388 AA.
AC   Q8K912;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-NOV-2008, entry version 36.
DE   RecName: Full=Mannitol-1-phosphate 5-dehydrogenase;
DE            EC=1.1.1.17;
GN   Name=mtlD; OrderedLocusNames=BUsg_551;
OS   Buchnera aphidicola subsp. Schizaphis graminum.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Buchnera.
OX   NCBI_TaxID=98794;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   MEDLINE=22084549; PubMed=12089438; DOI=10.1126/science.1071278;
RA   Tamas I., Klasson L., Canbaeck B., Naeslund A.K., Eriksson A.-S.,
RA   Wernegreen J.J., Sandstroem J.P., Moran N.A., Andersson S.G.E.;
RT   "50 million years of genomic stasis in endosymbiotic bacteria.";
RL   Science 296:2376-2379(2002).
CC   -!- CATALYTIC ACTIVITY: D-mannitol 1-phosphate + NAD(+) = D-fructose
CC       6-phosphate + NADH.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
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DR   EMBL; AE013218; AAM68089.1; -; Genomic_DNA.
DR   RefSeq; NP_660878.1; -.
DR   GeneID; 1005536; -.
DR   GenomeReviews; AE013218_GR; BUsg_551.
DR   KEGG; bas:BUsg551; -.
DR   HOGENOM; Q8K912; -.
DR   BioCyc; BAPH198804:BUSG551-MON; -.
DR   GO; GO:0050662; F:coenzyme binding; IEA:InterPro.
DR   GO; GO:0008926; F:mannitol-1-phosphate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00196; -; 1.
DR   InterPro; IPR013328; DHase_multihelical.
DR   InterPro; IPR013118; Mannitol_DHase_C.
DR   InterPro; IPR000669; Mannitol_DHase_core.
DR   InterPro; IPR013131; Mannitol_DHase_N.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Gene3D; G3DSA:1.10.1040.10; Opine_DH; 1.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   PROSITE; PS00974; MANNITOL_DHGENASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    388       Mannitol-1-phosphate 5-dehydrogenase.
FT                                /FTId=PRO_0000170700.
FT   NP_BIND       3     14       NAD (By similarity).
SQ   SEQUENCE   388 AA;  44572 MW;  58A1E3D0EA624A82 CRC64;
     MRALHFGAGN IGRGFIARVL LKSDFNLIFS DVDQNIINAI NNYKKYKIKL IDNSFEKIIN
     INNISAINSY DPNVLNVISH VDLITTAAGV NALYKIASIL IEGIILRINL KCKKPLNIIA
     CENKIKATSF LKKIIFDKIP LKYHDYFDEY IGFVDCTIDT IVPTFSSFKE ENSLFVIAEN
     FKEWIVDVNQ FKGMVPKIID MTLSDNLTSF IDRKILTLNT GHAIAAYLGL MKNYKNICEA
     MSDFSIQRIV KDAMYESGLV LIKRYNFNKK DHLSYIDKIF VRFKNPFILD KLERIARNPL
     QKLSKDERLI QPFVEAMKYN LPYFNLVKGI AAALHYRNIN DIQSIKLSSL IKEEGLEETL
     VKVCKLNANS NEIRIIISEY HSIIKDFL
//