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UniProtKB/Swiss-Prot entry Q8K4X7


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PLCD_MOUSE
Primary accession number Q8K4X7
Secondary accession numbers Q3TKN0 Q9DB84
Integrated into Swiss-Prot on June 21, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 44)
Name and origin of the protein
Protein name 1-acyl-sn-glycerol-3-phosphate acyltransferase delta
Synonyms EC 2.3.1.51
1-AGP acyltransferase 4
1-AGPAT 4
Lysophosphatidic acid acyltransferase delta
LPAAT-delta
1-acylglycerol-3-phosphate O-acyltransferase 4
Gene name
Name: Agpat4
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Cerebellum;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D., Nagaraja R.;
"Genomic sequence analysis in the mouse T-complex region.";
Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AK005139; BAB23837.2; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK166917; BAE39115.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF485269; AAM33375.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC047281; AAH47281.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_080920.2; -.
UniGene Mm.258300
3D structure databases
ModBase Q8K4X7.
Protein-protein interaction databases
IntAct Q8K4X7; -.
Organism-specific databases
MGI MGI:1915512; Agpat4.
Gene expression databases
ArrayExpress Q8K4X7; -.
GermOnline ENSMUSG00000023827; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0003841; Molecular function: 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred from electronic annotation from EC).
GO:0008654; Biological process: phospholipid biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002123; Acyltransferase.
Graphical view of domain structure.
Pfam PF01553; Acyltransferase; 1.
Pfam graphical view of domain structure.
SMART SM00563; PlsC; 1.
SMART graphical view of domain structure.
ProtoNet Q8K4X7.
Genome annotation databases
Ensembl ENSMUSG00000023827; Mus musculus. [Contig view]
GeneID 68262; -.
KEGG mmu:68262; -.
Phylogenomic databases
HOGENOM Q8K4X7; -.
HOVERGEN Q8K4X7; -.
Other
NextBio 326850; -.
SOURCE Agpat4; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Membrane; Phospholipid biosynthesis; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   378  378     1-acyl-sn-glycerol-3-phosphate acyltransferase delta. PRO_0000208198
TRANSMEM   11    31  21     Potential. 
TRANSMEM   125   145  21     Potential. 
TRANSMEM   311   331  21     Potential. 
TRANSMEM   338   358  21     Potential. 
MOTIF   96   101  6     HXXXXD motif. 
Sequence information
Length: 378 AA [This is the length of the unprocessed precursor] Molecular weight: 43810 Da [This is the MW of the unprocessed precursor] CRC64: 3D9EF15B6A5E49BC [This is a checksum on the sequence]
        10         20         30         40         50         60 
MDLIGLLKSQ FLCHLVFCYV FIASGLIVNA IQLCTLVIWP INKQLFRKIN ARLCYCVSSQ 

        70         80         90        100        110        120 
LVMLLEWWSG TECTIYTDPK ACPHYGKENA IVVLNHKFEI DFLCGWSLAE RLGILGNSKV 

       130        140        150        160        170        180 
LAKKELAYVP IIGWMWYFVE MIFCTRKWEQ DRQTVAKSLL HLRDYPEKYL FLIHCEGTRF 

       190        200        210        220        230        240 
TEKKHQISMQ VAQAKGLPSL KHHLLPRTKG FAITVKCLRD VVPAVYDCTL NFRNNENPTL 

       250        260        270        280        290        300 
LGVLNGKKYH ADCYVRRIPM EDIPEDEDKC SAWLHKLYQE KDAFQEEYYR TGVFPETPWV 

       310        320        330        340        350        360 
PPRRPWSLVN WLFWASLLLY PFFQFLVSMV SSGSSVTLAS LVLIFCMASM GVRWMIGVTE 

       370 
IDKGSAYGNI DNKRKQTD 

Q8K4X7 in FASTA format

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View entry in raw text format (no links)
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BLAST logo BLAST submission on ExPASy/SIB
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