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UniProtKB/Swiss-Prot entry Q8K4T5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DUS19_MOUSE
Primary accession number Q8K4T5
Secondary accession numbers None
Integrated into Swiss-Prot on June 7, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 38)
Name and origin of the protein
Protein name Dual specificity protein phosphatase 19
Synonyms EC 3.1.3.48
EC 3.1.3.16
Stress-activated protein kinase pathway-regulating phosphatase 1
Protein phosphatase SKRP1
Gene name
Name: Dusp19
Synonyms: Skrp1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1074/jbc.M200837200; PubMed=11959861 [NCBI, ExPASy, EBI, Israel, Japan]
Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.;
"A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway.";
J. Biol. Chem. 277:23909-23918(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB051896; BAC01163.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
UniGene Mm.306818
3D structure databases
HSSP Q05923; 1M3G. [HSSP ENTRY / PDB]
ModBase Q8K4T5.
Organism-specific databases
MGI MGI:1915332; Dusp19.
Gene expression databases
ArrayExpress Q8K4T5; -.
CleanEx MM_DUSP19; -.
GermOnline ENSMUSG00000027001; Mus musculus.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from direct assay from MGI).
GO:0008579; Molecular function: JUN kinase phosphatase activity (inferred from direct assay from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from MGI).
GO:0004725; Molecular function: protein tyrosine phosphatase activity (inferred from electronic annotation from EC).
GO:0008330; Molecular function: protein tyrosine/threonine phosphatase activity (inferred from direct assay from MGI).
GO:0000188; Biological process: inactivation of MAPK activity (inferred from direct assay from MGI).
GO:0007254; Biological process: JNK cascade (inferred from direct assay from MGI).
GO:0006470; Biological process: protein amino acid dephosphorylation (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR000387; Tyr_Pase.
IPR016130; Tyr_Pase_AS.
IPR000340; Tyr_Pase_dual_specific.
Graphical view of domain structure.
Pfam PF00782; DSPc; 1.
Pfam graphical view of domain structure.
SMART SM00195; DSPc; 1.
SMART graphical view of domain structure.
PROSITE PS00383; TYR_PHOSPHATASE_1; FALSE_NEG.
PS50056; TYR_PHOSPHATASE_2; 1.
PS50054; TYR_PHOSPHATASE_DUAL; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8K4T5.
Genome annotation databases
Ensembl ENSMUSG00000027001; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q8K4T5; -.
HOVERGEN Q8K4T5; -.
Other
SOURCE Dusp19; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Hydrolase; Protein phosphatase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   220  220     Dual specificity protein phosphatase 19. PRO_0000094833
DOMAIN   132   196  65     Tyrosine-protein phosphatase. 
ACT_SITE   149   149        Phosphocysteine intermediate (By similarity). 
Sequence information
Length: 220 AA [This is the length of the unprocessed precursor] Molecular weight: 24181 Da [This is the MW of the unprocessed precursor] CRC64: 5977D907CA7D3EDD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG GGCGYVQDLT 

        70         80         90        100        110        120 
LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG VENAFLSEFT YKTISILDVP 

       130        140        150        160        170        180 
ETNILSYFPE CFEFIEQAKL KDGVVLVHCN AGVSRAAAIV IGFLMSSEEA TFTTALSLVK 

       190        200        210        220 
EARPSICPNP GFMEQLRTYQ VGKESNGGDK VPAEDTTHGL
Q8K4T5 in FASTA format

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