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UniProtKB/Swiss-Prot entry Q8K2X1

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AT10D_MOUSE
Primary accession number Q8K2X1
Secondary accession numbers None
Integrated into Swiss-Prot on March 25, 2003
Sequence was last modified on March 25, 2003 (Sequence version 2)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Probable phospholipid-transporting ATPase VD
Synonyms ATPVD
EC 3.6.3.1
Gene name
Name: Atp10d
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS ALA-700 AND LEU-716.
STRAIN=BALB/c, C57BL/6, CAST, MAI, MBT, and PWK;
TISSUE=Monocyte;
DOI=10.1007/s00335-002-3032-3; PubMed=12532265 [NCBI, ExPASy, EBI, Israel, Japan]
Flamant S., Pescher P., Lemercier B., Clement-Ziza M., Kepes F., Fellous M., Milon G., Marchal G., Besmond C.;
"Characterization of a putative type IV aminophospholipid transporter P-type ATPase.";
Mamm. Genome 14:21-30(2003).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1079-1416 (ISOFORM 2).
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ441079; CAD29578.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC029551; AAH29551.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_700438.2; -.
UniGene Mm.32775
3D structure databases
ModBase Q8K2X1.
PTM databases
PhosphoSite Q8K2X1; -.
Organism-specific databases
MGI MGI:2450125; Atp10d.
Gene expression databases
ArrayExpress Q8K2X1; -.
CleanEx MM_ATP10D; -.
GermOnline ENSMUSG00000046808; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (non-traceable author statement from UniProtKB).
GO:0005524; Molecular function: ATP binding (non-traceable author statement from UniProtKB).
GO:0015662; Molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism (inferred from electronic annotation from InterPro).
GO:0000287; Molecular function: magnesium ion binding (non-traceable author statement from UniProtKB).
GO:0004012; Molecular function: phospholipid-translocating ATPase activity (non-traceable author statement from UniProtKB).
GO:0006812; Biological process: cation transport (non-traceable author statement from UniProtKB).
GO:0015914; Biological process: phospholipid transport (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR001757; ATPase_P.
IPR006539; Flippase.
Graphical view of domain structure.
PANTHER PTHR11939; ATPase_P; 1.
PRINTS PR00119; CATATPASE.
TIGRFAMs TIGR01652; ATPase-Plipid; 1.
TIGR01494; ATPase_P-type; 3.
PROSITE PS00154; ATPASE_E1_E2; 1.
ProtoNet Q8K2X1.
Genome annotation databases
Ensembl ENSMUSG00000046808; Mus musculus. [Contig view]
GeneID 231287; -.
KEGG mmu:231287; -.
Phylogenomic databases
HOGENOM Q8K2X1; -.
HOVERGEN Q8K2X1; -.
Other
NextBio 380484; -.
SOURCE Atp10d; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; ATP-binding; Hydrolase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1416  1416     Probable phospholipid-transporting ATPase VD. PRO_0000046384
TOPO_DOM   1     97  97     Cytoplasmic (Potential). 
TRANSMEM   98    118  21     Potential. 
TOPO_DOM   119    120  2     Extracellular (Potential). 
TRANSMEM   121    141  21     Potential. 
TOPO_DOM   142    321  180     Cytoplasmic (Potential). 
TRANSMEM   322    342  21     Potential. 
TOPO_DOM   343    365  23     Extracellular (Potential). 
TRANSMEM   366    386  21     Potential. 
TOPO_DOM   387   1110  724     Cytoplasmic (Potential). 
TRANSMEM   1111   1131  21     Potential. 
TOPO_DOM   1132   1142  11     Extracellular (Potential). 
TRANSMEM   1143   1163  21     Potential. 
TOPO_DOM   1164   1192  29     Cytoplasmic (Potential). 
TRANSMEM   1193   1213  21     Potential. 
TOPO_DOM   1214   1221  8     Extracellular (Potential). 
TRANSMEM   1222   1242  21     Potential. 
TOPO_DOM   1243   1252  10     Cytoplasmic (Potential). 
TRANSMEM   1253   1273  21     Potential. 
TOPO_DOM   1274   1289  16     Extracellular (Potential). 
TRANSMEM   1290   1310  21     Potential. 
TOPO_DOM   1311   1416  106     Cytoplasmic (Potential). 
NP_BIND   993   1000  8     ATP (Potential). 
NP_BIND   1361   1368  8     ATP (Potential). 
ACT_SITE   438    438        4-aspartylphosphate intermediate (By similarity). 
METAL   1053   1053        Magnesium (By similarity). 
METAL   1057   1057        Magnesium (By similarity). 
VAR_SEQ   1120   1135        Missing (in isoform 2). VSP_006959
VARIANT   700    700  1     V -> A (in strain: CAST, MAI, MBT and PWK). 
VARIANT   716    716  1     S -> L (in strain: CAST, MAI, MBT and PWK). 
CONFLICT   1239   1239        L -> F (in Ref. 2; AAH29551). 
Sequence information
Length: 1416 AA [This is the length of the unprocessed precursor] Molecular weight: 158330 Da [This is the MW of the unprocessed precursor] CRC64: 1799CCF062E22BB0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTELLQWARH HWRRLSHGRA QGEDERPYNY ASLLACGGKS SRTPRPAGKH RVVIPHLQCF 

        70         80         90        100        110        120 
KDEYERFSGT YVNNRIRTTK YTLLNFVPRN LFEQFHRAAN LYFLFLVVLN WVPLVEAFQK 

       130        140        150        160        170        180 
EITMLPLVVV LTIIAIKDGL EDYRKYKIDK QINNLITKVY SRKEKKYIDC CWKNVTVGDF 

       190        200        210        220        230        240 
IRLSCNEIIP ADMVLLFSTD PDGICHIETS GLDGESNLKQ RQVVRGYTEQ DSEVDPEKFS 

       250        260        270        280        290        300 
SRIECESPNN DLSRFRGFLE HANKERVGLS KENLLLRGCT IRNTEAVVGI VVYAGHETKA 

       310        320        330        340        350        360 
MLNNSGPRYK RSKLERRANT DVLWCVLLLI VMCLTGALGH GIWLSRYENM LFFNIPEPDG 

       370        380        390        400        410        420 
RVISPVLTGF YVFWTMIILL QVLIPISLYV SIEIVKLGQI YFIQSDVDFY NEKMDSTIQC 

       430        440        450        460        470        480 
RALNITEDLG QIQYLFSDKT GTLTENKMVF RRCSVAGFDY CHEENAKRLE SYQEAVSEEE 

       490        500        510        520        530        540 
ECTDTLGGSL SNMARPRAQG CRTVPSGPLG KPSAQLSGST SAVGNGEGSG EVPHSRQAAF 

       550        560        570        580        590        600 
SSPMETDVVP DTRLLDKFSQ LTPQLLTGLD GTAQSSPLET LYIMDFFIAL AICNTVVVSA 

       610        620        630        640        650        660 
PNQPRQKIGL SSLGGMPIKS LEEIKNIFQK LSVRRSSSPS LASGKDSSSG TPCAFVSRIS 

       670        680        690        700        710        720 
FFSRPKLSPP MEDESSQMDE IPQASNSACC TETEAQNRAV GLSVSSAEAL SGPPPSASNL 

       730        740        750        760        770        780 
CYEAESPDEA ALVYAARAYR CTLQSRTPEQ VMVDFAALGS LTFQLLHILP FDSVRKRMSV 

       790        800        810        820        830        840 
VVRHPLSKQV VVYTKGADSV IMELLSVAAS DGTNPEQQMI IRERTQRHLD EYAKRGLRTL 

       850        860        870        880        890        900 
CVAKKVMSDT EYAEWLRNHF LAETSIDNRE ELLVESAMRL ENKLTLLGAT GIEDRLQEGV 

       910        920        930        940        950        960 
PESIEALHQA GIKIWMLTGD KQETAVNIAY ACKLLEPDDK LFILNTQSQD ACGMLMSAIL 

       970        980        990       1000       1010       1020 
EELQKRAQVS PELASSRKNF PQPSDAQGQG RAGLVITGKT LEFALQESLQ RQFLELTAWC 

      1030       1040       1050       1060       1070       1080 
QAVICCRATP LQKSEVVKLV RNHHHVLTLP IGDGANDVSM IQVADIGIGV SGQEGMQAVM 

      1090       1100       1110       1120       1130       1140 
ASDFAISQFR HLSKLLLVHG HWCYTRLSNM ILYFFYKNVA YVNLLFWYQF FCGFSGTSMT 

      1150       1160       1170       1180       1190       1200 
DYWVLIFFNL LFTSVPPIIY GVLEKDVSAE TLLQLPELYR SGQRSEEYLP LTFWITLLDA 

      1210       1220       1230       1240       1250       1260 
FYQSLVCFFV PYFTYQGSDI DIFTFGNPLN TAALFIILLH LVIESKSLTW IHMLVTVGSI 

      1270       1280       1290       1300       1310       1320 
LSYFFFALAF GALCVTCNPP SNPYGIMRKH MLDPVFYLVC VLTTFVALLP RFLYRVLQGS 

      1330       1340       1350       1360       1370       1380 
VFPSPVLRAK YFDRLPPEER AEALKRWRGT AKVNHVASKH ASQSAAMSGR PTPGSSAVLA 

      1390       1400       1410 
MKSATVSTVE QSTRETALDR GCSEPGASKM TGSSAS
Q8K2X1 in FASTA format

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