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UniProtKB/Swiss-Prot entry Q8K2C8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PLCF_MOUSE
Primary accession number Q8K2C8
Secondary accession number Q3TF78
Integrated into Swiss-Prot on June 21, 2005
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name 1-acyl-sn-glycerol-3-phosphate acyltransferase zeta [Precursor]
Synonyms EC 2.3.1.51
1-AGP acyltransferase 6
1-AGPAT 6
Lysophosphatidic acid acyltransferase zeta
LPAAT-zeta
Gene name
Name: Agpat6
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II;
Guo J.H., Dai F.Y., Yu L.;
"A novel gene encodes a product of putative lysophosphatidic acid acyltransferase.";
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Heart, and Testis;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N;
TISSUE=Mammary tumor;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF406611; AAP97283.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK045235; BAC32273.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK077561; BAC36864.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK083589; BAC38962.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK161270; BAE36282.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK169257; BAE41020.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC031767; AAH31767.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_061213.2; -.
UniGene Mm.200898
3D structure databases
ModBase Q8K2C8.
Organism-specific databases
MGI MGI:2142716; Agpat6.
Gene expression databases
ArrayExpress Q8K2C8; -.
GermOnline ENSMUSG00000031545; Mus musculus.
Ontologies
GO
GO:0030176; Cellular component: integral to endoplasmic reticulum membrane (non-traceable author statement from UniProtKB).
GO:0003841; Molecular function: 1-acylglycerol-3-phosphate O-acyltransferase activity (inferred from electronic annotation from EC).
GO:0008780; Molecular function: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity (non-traceable author statement from UniProtKB).
GO:0046339; Biological process: diacylglycerol metabolic process (inferred from mutant phenotype from MGI).
GO:0006631; Biological process: fatty acid metabolic process (inferred from mutant phenotype from MGI).
GO:0002071; Biological process: glandular epithelial cell maturation (inferred from mutant phenotype from MGI).
GO:0007595; Biological process: lactation (inferred from mutant phenotype from UniProtKB).
GO:0030879; Biological process: mammary gland development (inferred from mutant phenotype from MGI).
GO:0040014; Biological process: regulation of multicellular organism growth (inferred from mutant phenotype from MGI).
GO:0019432; Biological process: triacylglycerol biosynthetic process (inferred from mutant phenotype from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002123; Acyltransferase.
Graphical view of domain structure.
Pfam PF01553; Acyltransferase; 1.
Pfam graphical view of domain structure.
SMART SM00563; PlsC; 1.
SMART graphical view of domain structure.
ProtoNet Q8K2C8.
Genome annotation databases
Ensembl ENSMUSG00000031545; Mus musculus. [Contig view]
GeneID 102247; -.
KEGG mmu:102247; -.
Phylogenomic databases
HOGENOM Q8K2C8; -.
HOVERGEN Q8K2C8; -.
Other
NextBio 355374; -.
SOURCE Agpat6; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Glycoprotein; Membrane; Phosphoprotein; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    37  37     Potential. 
CHAIN   38   456  419     1-acyl-sn-glycerol-3-phosphate acyltransferase zeta. PRO_0000024704
TRANSMEM   156   176  21     Potential. 
TRANSMEM   180   200  21     Potential. 
MOTIF   248   253  6     HXXXXD motif (By similarity). 
MOD_RES   218   218        Phosphotyrosine (By similarity). 
CARBOHYD   247   247        N-linked (GlcNAc...) (Potential). 
CARBOHYD   327   327        N-linked (GlcNAc...) (Potential). 
CARBOHYD   328   328        N-linked (GlcNAc...) (Potential). 
CARBOHYD   362   362        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 456 AA [This is the length of the unprocessed precursor] Molecular weight: 52181 Da [This is the MW of the unprocessed precursor] CRC64: 2C3E1C37044C14FA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MFLLLPFDSL IVNLLGISLT VLFTLLLVFI IVPAIFGVSF GIRKLYMKTL LKIFAWATLR 

        70         80         90        100        110        120 
MERGAKERNH QLYKPYTNGI IAKDPTSLEE EIKEIRRSGS SKALDKTPEF ELSDIFYFCR 

       130        140        150        160        170        180 
KGMETIMDDE VTKRFSAEEL ESWNLLSRTN YNFQYISLRL TILWGLGVLI RYCFLLPLRI 

       190        200        210        220        230        240 
ALAFTGIGLL VVGTTMVGYL PNGRFKEFLS KHVHLMCYRI CVRALTAIIT YHNRKNRPRN 

       250        260        270        280        290        300 
GGICVANHTS PIDVIILASD GYYAMVGQVH GGLMGVIQRA MVKACPHVWF ERSEVKDRHL 

       310        320        330        340        350        360 
VAKRLTEHVQ DKSKLPILIF PEGTCINNTS VMMFKKGSFE IGATVYPVAI KYDPQFGDAF 

       370        380        390        400        410        420 
WNSSKYGMVT YLLRMMTSWA IVCSVWYLPP MTREKDEDAV QFANRVKSAI ARQGGLVDLL 

       430        440        450 
WDGGLKREKV KDTFKEEQQK LYSKMIVGNH EDRSRS 

Q8K2C8 in FASTA format

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