ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q8K1S3


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name UNC5B_MOUSE
Primary accession number Q8K1S3
Secondary accession numbers Q3U4F2 Q6PFH0 Q80Y85 Q9D398
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name Netrin receptor UNC5B [Precursor]
Synonyms Protein unc-5 homolog B
Unc-5 homolog 2
Gene name
Name: Unc5b
Synonyms: Unc5h2
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
DOI=10.1016/S0925-4773(02)00248-4; PubMed=12351186 [NCBI, ExPASy, EBI, Israel, Japan]
Engelkamp D.;
"Cloning of three mouse Unc5 genes and their expression patterns at mid-gestation.";
Mech. Dev. 118:191-197(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J, and NOD;
TISSUE=Medulla oblongata;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
STRAIN=C57BL/6;
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
TISSUE SPECIFICITY.
DOI=10.1016/S1567-133X(03)00047-4; PubMed=12799072 [NCBI, ExPASy, EBI, Israel, Japan]
Dalvin S., Anselmo M.A., Prodhan P., Komatsuzaki K., Schnitzer J.J., Kinane T.B.;
"Expression of Netrin-1 and its two receptors DCC and UNC5H2 in the developing mouse lung.";
Gene Expr. Patterns 3:279-283(2003).
[5]
X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 854-943.
RIKEN structural genomics initiative (RSGI);
"Crystal structure of the UNC5H2 death domain.";
Submitted (JAN-2005) to the PDB data bank.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ487853; CAD32251.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK018177; BAB31108.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK154271; BAE32479.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC048162; AAH48162.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC057560; AAH57560.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_084046.2; -.
UniGene Mm.290433
3D structure databases
PDB
1WMG; X-ray; 2.10 A; A/B/C/D/E/F=854-943.[ExPASy / RCSB / EBI]
PDBsum 1WMG; -.
ModBase Q8K1S3.
Organism-specific databases
MGI MGI:894703; Unc5b.
Gene expression databases
ArrayExpress Q8K1S3; -.
CleanEx MM_UNC5B; -.
GermOnline ENSMUSG00000020099; Mus musculus.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from electronic annotation from InterPro).
GO:0004872; Molecular function: receptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0006915; Biological process: apoptosis (inferred from electronic annotation from UniProtKB-KW).
GO:0007275; Biological process: multicellular organismal development (inferred from electronic annotation from UniProtKB-KW).
GO:0007165; Biological process: signal transduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR000488; Death.
IPR011029; DEATH_like.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR000884; TSP1.
IPR008085; TSP_1.
IPR000906; ZU5.
Graphical view of domain structure.
Gene3D G3DSA:1.10.533.10; DEATH_like; 1.
G3DSA:2.60.40.10; Ig-like_fold; 2.
Pfam PF00531; Death; 1.
PF07679; I-set; 1.
PF00090; TSP_1; 2.
PF00791; ZU5; 1.
Pfam graphical view of domain structure.
PRINTS PR01705; TSP1REPEAT.
SMART SM00005; DEATH; 1.
SM00408; IGc2; 1.
SM00209; TSP1; 2.
SM00218; ZU5; 1.
SMART graphical view of domain structure.
PROSITE PS50017; DEATH_DOMAIN; 1.
PS50835; IG_LIKE; 1.
PS50092; TSP1; 2.
PS51145; ZU5; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet Q8K1S3.
Genome annotation databases
Ensembl ENSMUSG00000020099; Mus musculus. [Contig view]
GeneID 107449; -.
KEGG mmu:107449; -.
Phylogenomic databases
HOGENOM Q8K1S3; -.
HOVERGEN Q8K1S3; -.
Other
NextBio 358822; -.
SOURCE Unc5b; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Alternative splicing; Apoptosis; Developmental protein; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Repeat; Signal; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    26  26     Potential. 
CHAIN   27   945  919     Netrin receptor UNC5B. PRO_0000036072
TOPO_DOM   27   377  351     Extracellular (Potential). 
TRANSMEM   378   398  21     Potential. 
TOPO_DOM   399   945  547     Cytoplasmic (Potential). 
DOMAIN   48   145  98     Ig-like. 
DOMAIN   153   242  90     Ig-like C2-type. 
DOMAIN   246   300  55     TSP type-1 1. 
DOMAIN   302   354  53     TSP type-1 2. 
DOMAIN   541   647  107     ZU5. 
DOMAIN   865   943  79     Death. 
REGION   707   725  19     Interaction with DCC (By similarity). 
SITE   412   413  2     Cleavage; by caspase-3 (By similarity). 
CARBOHYD   222   222        N-linked (GlcNAc...) (Potential). 
CARBOHYD   347   347        N-linked (GlcNAc...) (Potential). 
DISULFID   69   128        By similarity. 
DISULFID   174   225        By similarity. 
DISULFID   258   295        By similarity. 
DISULFID   262   299        By similarity. 
DISULFID   273   285        By similarity. 
VAR_SEQ   356   367        NQRTLNDPKSHP -> T (in isoform 2). VSP_011699
CONFLICT   238   238        T -> A (in Ref. 2; BAB31108). 
CONFLICT   394   394        V -> E (in Ref. 2; BAB31108). 
CONFLICT   679   679        T -> S (in Ref. 2; BAB31108). 
CONFLICT   874   874        N -> D (in Ref. 2; BAB31108). 
HELIX   860   871  12      
HELIX   873   875  3      
HELIX   880   886  7      
HELIX   890   892  3      
HELIX   893   897  5      
HELIX   902   913  12      
TURN   917   919  3      
HELIX   920   929  10      
HELIX   933   941  9      
Sequence information
Length: 945 AA [This is the length of the unprocessed precursor] Molecular weight: 103739 Da [This is the MW of the unprocessed precursor] CRC64: 80E896F0F0E06012 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRARSGVRSA LLLALLLCWD PTPSLAGVDS AGQVLPDSYP SAPAEQLPYF LLEPQDAYIV 

        70         80         90        100        110        120 
KNKPVELHCR AFPATQIYFK CNGEWVSQND HVTQESLDEA TGLRVREVQI EVSRQQVEEL 

       130        140        150        160        170        180 
FGLEDYWCQC VAWSSSGTTK SRRAYIRIAY LRKNFDQEPL AKEVPLDHEV LLQCRPPEGV 

       190        200        210        220        230        240 
PVAEVEWLKN EDVIDPAQDT NFLLTIDHNL IIRQARLSDT ANYTCVAKNI VAKRRSTTAT 

       250        260        270        280        290        300 
VIVYVNGGWS SWAEWSPCSN RCGRGWQKRT RTCTNPAPLN GGAFCEGQAF QKTACTTVCP 

       310        320        330        340        350        360 
VDGAWTEWSK WSACSTECAH WRSRECMAPP PQNGGRDCSG TLLDSKNCTD GLCVLNQRTL 

       370        380        390        400        410        420 
NDPKSHPLET SGDVALYAGL VVAVFVVVAV LMAVGVIVYR RNCRDFDTDI TDSSAALTGG 

       430        440        450        460        470        480 
FHPVNFKTAR PNNPQLLHPS APPDLTASAG IYRGPVYALQ DSADKIPMTN SPLLDPLPSL 

       490        500        510        520        530        540 
KIKVYNSSTI GSGSGLADGA DLLGVLPPGT YPGDFSRDTH FLHLRSASLG SQHLLGLPRD 

       550        560        570        580        590        600 
PSSSVSGTFG CLGGRLSLPG TGVSLLVPNG AIPQGKFYDL YLHINKAEST LPLSEGSQTV 

       610        620        630        640        650        660 
LSPSVTCGPT GLLLCRPVVL TVPHCAEVIA GDWIFQLKTQ AHQGHWEEVV TLDEETLNTP 

       670        680        690        700        710        720 
CYCQLEAKSC HILLDQLGTY VFMGESYSRS AVKRLQLAIF APALCTSLEY SLRVYCLEDT 

       730        740        750        760        770        780 
PVALKEVLEL ERTLGGYLVE EPKPLLFKDS YHNLRLSLHD IPHAHWRSKL LAKYQEIPFY 

       790        800        810        820        830        840 
HVWNGSQRAL HCTFTLERHS LASTEFTCKV CVRQVEGEGQ IFQLHTTLAE TPAGSLDALC 

       850        860        870        880        890        900 
SAPGNAITTQ LGPYAFKIPL SIRQKICSSL DAPNSRGNDW RLLAQKLSMD RYLNYFATKA 

       910        920        930        940 
SPTGVILDLW EARQQDDGDL NSLASALEEM GKSEMLVAMA TDGDC 

Q8K1S3 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!