ID   BDH2_MOUSE              Reviewed;         245 AA.
AC   Q8JZV9;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-NOV-2008, entry version 47.
DE   RecName: Full=3-hydroxybutyrate dehydrogenase type 2;
DE            EC=1.1.1.30;
DE   AltName: Full=R-beta-hydroxybutyrate dehydrogenase;
DE   AltName: Full=Dehydrogenase/reductase SDR family member 6;
GN   Name=Bdh2; Synonyms=Dhrs6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate
CC       + NADH.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; BC036998; AAH36998.1; -; mRNA.
DR   RefSeq; NP_081484.1; -.
DR   UniGene; Mm.45121; -.
DR   HSSP; P97852; 1GZ6.
DR   SMR; Q8JZV9; 1-245.
DR   PhosphoSite; Q8JZV9; -.
DR   Ensembl; ENSMUSG00000028167; Mus musculus.
DR   GeneID; 69772; -.
DR   KEGG; mmu:69772; -.
DR   NMPDR; fig|10090.3.peg.9033; -.
DR   MGI; MGI:1917022; Bdh2.
DR   HOVERGEN; Q8JZV9; -.
DR   NextBio; 330302; -.
DR   ArrayExpress; Q8JZV9; -.
DR   CleanEx; MM_BDH2; -.
DR   GermOnline; ENSMUSG00000028167; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; ISS:HGNC.
DR   GO; GO:0003858; F:3-hydroxybutyrate dehydrogenase activity; ISS:HGNC.
DR   GO; GO:0051287; F:NAD binding; ISS:HGNC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; ISS:HGNC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR002198; DHase_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DHase.
DR   InterPro; IPR016040; NAD(P)-bd.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; NAD; Oxidoreductase; Phosphoprotein.
FT   CHAIN         1    245       3-hydroxybutyrate dehydrogenase type 2.
FT                                /FTId=PRO_0000042581.
FT   NP_BIND      10     37       NAD (By similarity).
FT   NP_BIND     180    184       NAD (By similarity).
FT   ACT_SITE    147    147       Proton acceptor (By similarity).
FT   BINDING      58     58       NAD (By similarity).
FT   BINDING     144    144       Substrate (By similarity).
FT   BINDING     151    151       NAD (By similarity).
FT   BINDING     188    188       Substrate (By similarity).
FT   BINDING     205    205       Substrate (By similarity).
FT   MOD_RES     132    132       Phosphoserine (By similarity).
SQ   SEQUENCE   245 AA;  26753 MW;  343A25B1F56B9CCF CRC64;
     MGRLDGKVIV LTAAAQGIGR ASALAFAREG AKVIATDINE SKLQELESYR GIQTRVLDVT
     KKRQIDQFAS EIERIDVLFN VAGFVHHGTI LDCEEKDWDF SMNLNVRSMF LMIKAFLPKM
     LAQKSGNIIN MSSVASSIKG VENRCVYSAT KAAVIGLTKS VAADFIQQGI RCNCVCPGTV
     DTPSLQERIQ ARDNPKEALK TFLNRQKTGR FASAEEVALL CVYLASDESA YVTGNPVIID
     GGWSL
//