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UniProtKB/Swiss-Prot entry Q8JZQ5

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ABP1_MOUSE
Primary accession number Q8JZQ5
Secondary accession numbers Q8R229 Q8VC36
Integrated into Swiss-Prot on May 24, 2004
Sequence was last modified on October 1, 2002 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 50)
Name and origin of the protein
Protein name Amiloride-sensitive amine oxidase [copper-containing] [Precursor]
Synonyms Diamine oxidase
DAO
EC 1.4.3.22
Amiloride-binding protein
ABP
Histaminase
Gene name
Name: Abp1
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC021880; AAH21880.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC022627; AAH22627.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC034215; AAH34215.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_083914.1; -.
UniGene Mm.213898
3D structure databases
ModBase Q8JZQ5.
PTM databases
PhosphoSite Q8JZQ5; -.
Organism-specific databases
MGI MGI:1923757; Abp1.
Gene expression databases
ArrayExpress Q8JZQ5; -.
GermOnline ENSMUSG00000029811; Mus musculus.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0008131; Molecular function: amine oxidase activity (inferred from electronic annotation from InterPro).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from InterPro).
GO:0008201; Molecular function: heparin binding (inferred from electronic annotation from UniProtKB-KW).
GO:0048038; Molecular function: quinone binding (inferred from electronic annotation from InterPro).
GO:0009308; Biological process: cellular amine metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000269; Cu_amine_oxidase.
IPR015798; Cu_amine_oxidase_C.
IPR015800; Cu_amine_oxidase_N2.
IPR015801; Cu_amine_oxidase_N2/3.
IPR015802; Cu_amine_oxidase_N3.
Graphical view of domain structure.
Gene3D G3DSA:3.10.450.40; CuNH_oxidase; 2.
G3DSA:2.70.98.20; Lyase_8_central; 1.
PANTHER PTHR10638; CuNH_oxidase; 1.
Pfam PF01179; Cu_amine_oxid; 1.
PF02727; Cu_amine_oxidN2; 1.
PF02728; Cu_amine_oxidN3; 1.
Pfam graphical view of domain structure.
PRINTS PR00766; CUDAOXIDASE.
PROSITE PS01164; COPPER_AMINE_OXID_1; 1.
PS01165; COPPER_AMINE_OXID_2; 1.
ProtoNet Q8JZQ5.
Genome annotation databases
Ensembl ENSMUSG00000029811; Mus musculus. [Contig view]
GeneID 76507; -.
KEGG mmu:76507; -.
NMPDR fig|10090.3.peg.14357; -.
Phylogenomic databases
HOVERGEN Q8JZQ5; -.
Other
NextBio 345286; -.
SOURCE Abp1; Mus musculus.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Copper; Glycoprotein; Heparin-binding; Metal-binding; Oxidoreductase; Secreted; Signal; TPQ.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    22  22     Potential. 
CHAIN   23   751  729     Amiloride-sensitive amine oxidase [copper-containing] (By similarity). PRO_0000035667
REGION   568   575  8     Heparin-binding (By similarity). 
ACT_SITE   373   373        Proton acceptor (By similarity). 
ACT_SITE   461   461        Schiff-base intermediate with substrate; via topaquinone (By similarity). 
METAL   510   510        Copper (By similarity). 
METAL   512   512        Copper (By similarity). 
METAL   519   519        Calcium 1 (By similarity). 
METAL   520   520        Calcium 1; via carbonyl oxygen (By similarity). 
METAL   521   521        Calcium 1 (By similarity). 
METAL   562   562        Calcium 2 (By similarity). 
METAL   653   653        Calcium 2; via carbonyl oxygen (By similarity). 
METAL   656   656        Calcium 2 (By similarity). 
METAL   658   658        Calcium 2 (By similarity). 
METAL   664   664        Calcium 1 (By similarity). 
METAL   665   665        Calcium 1; via carbonyl oxygen (By similarity). 
METAL   675   675        Copper (By similarity). 
MOD_RES   461   461        2',4',5'-topaquinone (By similarity). 
CARBOHYD   61    61        N-linked (GlcNAc...) (Potential). 
CARBOHYD   110   110        N-linked (GlcNAc...) (Potential). 
CARBOHYD   538   538        N-linked (GlcNAc...) (Potential). 
CARBOHYD   745   745        N-linked (GlcNAc...) (Potential). 
CONFLICT   20    20        A -> P (in Ref. 1; AAH21880). 
Sequence information
Length: 751 AA [This is the length of the unprocessed precursor] Molecular weight: 85424 Da [This is the MW of the unprocessed precursor] CRC64: 4E9682DA7C967AC7 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLAFGWAAV ILLLQTADTA SAVTTPHDKA RIFADLSPQE IKAVHSFLMS RKELGLESSK 

        70         80         90        100        110        120 
NLTLAKNSVF LIEMLLPKKK NVLKFLDEGR KSPVREARAI IFFGAQDHPN VTEFAVGPLP 

       130        140        150        160        170        180 
RPCYVQALSP RPGHHLSWSS RPISTAEYDL LYHMLNRAIT PLHQFFLDTT GFSFLGCDDR 

       190        200        210        220        230        240 
FLTFTDVAPR GVESGQRRSW LIVQRYVEGY FLHPTGLEIL VDHSSTDVQD WRVEQLWYNG 

       250        260        270        280        290        300 
KFYNSPEELA QKYAVGEVEA VVLEEVVLED PLPGATEQPP LFSSYKPRGE FHTPVTVAGP 

       310        320        330        340        350        360 
HVVQPSGPRY KLEGNVVLYG DWSFSYRLRS SSGLQIFNVL FGGERVAYEV SVQEAVALYG 

       370        380        390        400        410        420 
GHTPAGMQTK YIDVGWGLGS VTHELAPGID CPETATFLDA FHYYDSDGPV LYPRALCLFE 

       430        440        450        460        470        480 
MPTGVPLRRH FDSNFKGGFN FYAGLKGYVL VLRTTSTVYN YDYIWDFIFY PNGVMETKMH 

       490        500        510        520        530        540 
ATGYVHATFY TPEGLRHGTR LQTHLLGNIH THLVHYRVDL DVAGTKNSFR TLKTKLENIT 

       550        560        570        580        590        600 
NPWSPSHSLV QPTLEQTQYS HEHQAAFRFG QTLPKYLLFS SPQKNRWGHR RSYRLQIHSM 

       610        620        630        640        650        660 
AEQVLPPGWQ EERAVTWARY PLAVTKYRES ERYSSSLYNQ NDPWDPPVVF EEFLRNNENI 

       670        680        690        700        710        720 
ENEDLVAWVT VGFLHIPHSE DVPNTATPGN CVGFLIRPFN FFEEDPSLAS RDTVIVWPQD 

       730        740        750 
NGLNHVQRWI PENRDCLVSP PFSYNGTYKP V
Q8JZQ5 in FASTA format

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