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[1]
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NUCLEOTIDE SEQUENCE [GENOMIC RNA].
DOI=10.1016/S0168-1702(02)00087-4; PubMed=12191779 [NCBI, ExPASy, EBI, Israel, Japan]
Groseth A.,
Stroeher U.,
Theriault S.,
Feldmann H.;
"Molecular characterization of an isolate from the 1989/90 epizootic of Ebola virus Reston among macaques imported into the United States.";
Virus Res. 87:155-163(2002).
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[2]
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NUCLEOTIDE SEQUENCE [GENOMIC RNA].
STRAIN=Isolate Pennsylvania-89;
DOI=10.1016/j.virol.2004.11.018; PubMed=15661171 [NCBI, ExPASy, EBI, Israel, Japan]
Boehmann Y.,
Enterlein S.,
Randolf A.,
Muehlberger E.I.;
"A reconstituted replication and transcription system for Ebola virus Reston and comparison with Ebola virus Zaire.";
Virology 332:406-417(2005).
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- FUNCTION: Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The transcriptase stutters on a specific sequence, resulting on a cotranscriptional editing of the glycoprotein (GP) mRNA. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
- CATALYTIC ACTIVITY: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
- SUBCELLULAR LOCATION: Cytoplasm. Virion (By similarity).
- SIMILARITY: Contains 1 RdRp catalytic domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 2212 AA [This is the length of the unprocessed precursor] |
Molecular weight: 252549 Da [This is the MW of the unprocessed precursor] |
CRC64: C28CE580881136E3 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MATQHTQYPD ARLSSPIVLD QCDLVTRACG LYSSYSLNPQ LRQCKLPKHI YRLKFDTIVS
70 80 90 100 110 120
KFLSDTPVAT LPIDYLVPIL LRSLTGHGDR PLTPTCNQFL DEIINYTLHD AAFLDYYLKA
130 140 150 160 170 180
TGAQDHLTNI ATREKLKNEI LNNDYVHQLF FWHDLSILAR RGRLNRGNNR STWFVHDEFI
190 200 210 220 230 240
DILGYGDYIF WKIPLSLLPV TIDGVPHAAT DWYQPTLFKE SILGHSQILS VSTAEILIMC
250 260 270 280 290 300
KDIITCRFNT SLIASIAKLE DVDVSDYPDP SDILKIYNAG DYVISILGSE GYKIIKYLEP
310 320 330 340 350 360
LCLAKIQLCS KFTERKGRFL TQMHLSVIND LRELISNRRL KDYQQEKIRD FHKILLQLQL
370 380 390 400 410 420
SPQQFCELFS VQKHWGHPIL HSEKAIQKVK RHATILKALR PNVIFETYCV FKYNIAKHYF
430 440 450 460 470 480
DSQGTWYSVI SDRNLTPGLN SFIKRNHFPS LPMIKDLLWE FYHLNHPPLF STKVISDLSI
490 500 510 520 530 540
FIKDRATAVE QTCWDAVFEP NVLGYNPPNK FSTKRVPEQF LEQEDFSIES VLNYAQELHY
550 560 570 580 590 600
LLPQNRNFSF SLKEKELNIG RTFGKLPYLT RNVQTLCEAL LADGLAKAFP SNMMVVTERE
610 620 630 640 650 660
QKESLLHQAS WHHTSDDFGE NATVRGSSFV TDLEKYNLAF RYEFTAPFIE YCNHCYGVRN
670 680 690 700 710 720
VFNWMHYLIP QCYMHVSDYY NPPHNVNLSN REYPPEGPSS YRGHLGGIEG LQQKLWTSIS
730 740 750 760 770 780
CAQISLVEIK TGFKLRSAVM GDNQCITVLS VFPLKTDPEE QEQSAEDNAA RVAASLAKVT
790 800 810 820 830 840
SACGIFLKPD ETFVHSGFIY FGKKQYLNGV QLPQSLKTAA RMAPLSDAIF DDLQGTLASI
850 860 870 880 890 900
GTAFERAISE TRHILPCRIV AAFHTYFAVR ILQYHHLGFN KGIDLGQLSL SKPLDYGTIT
910 920 930 940 950 960
LTLAVPQVLG GLSFLNPEKC FYRNFGDPVT SGLFQLRVYL EMVNMKDLFC PLISKNPGNC
970 980 990 1000 1010 1020
SAIDFVLNPS GLNVPGSQDL TSFLRQIVRR SITLTARNKL INTLFHASAD LEDEMVCKWL
1030 1040 1050 1060 1070 1080
LSSNPVMSRF AADIFSRTPS GKRLQILGYL EGTRTLLASK IINNNSETPV LDKLRKITLQ
1090 1100 1110 1120 1130 1140
RWNLWFSYLD HCDQLLADAL QKISCTVDLA QILREYTWSH ILEGRSLIGA TLPCMVEQFK
1150 1160 1170 1180 1190 1200
VKWLGQYEPC PECLNKKGSN AYVSVAVKDQ VVSAWPNTSR ISWTIGSGVP YIGSRTEDKI
1210 1220 1230 1240 1250 1260
GQPAIKPRCP SSALKEAIEL ASRLTWVTQG GSNSEQLIRP FLEARVNLSV SEVLQMTPSH
1270 1280 1290 1300 1310 1320
YSGNIVHRYN DQYSPHSFMA NRMSNTATRL IVSTNTLGEF SGGGQAARDS NIIFQNVINL
1330 1340 1350 1360 1370 1380
AVALYDIRFR NTNTSDIRHN RAHLHLTECC TKEVPAQYLT YTSALNLDLS RYRDNELIYD
1390 1400 1410 1420 1430 1440
SNPLKGGLNC NLTIDSPLVK GPRLNMIEDD LLRFPHLSGW ELAKTVVQSI ISDNSNSSTD
1450 1460 1470 1480 1490 1500
PISSGETRSF TTHFLTYPQI GLLYSFGAVL CFYLGNTILW TKKLDYEQFL YYLHNQLHNL
1510 1520 1530 1540 1550 1560
PHRALRVFKP TFKHASVMSR LMEIDSNFSI YIGGTSGDRG LSDAARLFLR TAIASFLQFL
1570 1580 1590 1600 1610 1620
KSWIIDRQKT IPLWIVYPLE GQQPESINEF LHKILGLLKQ GPKSIPKEVS IQNDGHLDLA
1630 1640 1650 1660 1670 1680
ENNYVYNSKS TASNFFHASL AYWRSRKSRK TQDHNDFSRG DGTLTEPVRK FSSNHQSDEK
1690 1700 1710 1720 1730 1740
YYNVTCGKSP KPQERKDFSQ YRLSNNGQTM SNHRKKGKFH KWNPCKMLME SQRGTVLTEG
1750 1760 1770 1780 1790 1800
DYFQNNTPPT DDVSSPHRLI LPFFKLGNHN HAHDQDAQEL MNQNIKQYLH QLRSMLDTTI
1810 1820 1830 1840 1850 1860
YCRFTGIVSS MHYKLDEVLL EYNSFDSAIT LAEGEGSGAL LLLQKYSTRL LFLNTLATEH
1870 1880 1890 1900 1910 1920
SIESEVVSGF STPRMLLPIM QKVHEGQVTV ILNNSASQIT DITSSMWLSN QKYNLPCQVE
1930 1940 1950 1960 1970 1980
IIMMDAETTE NLNRSQLYRA VYNLILDHID PQYLKVVVLK VFLSDIEGIL WINDYLAPLF
1990 2000 2010 2020 2030 2040
GAGYLIKPIT SSARSSEWYL CLSNLISTNR RSAHQTHKAC LGVIRDALQA QVQRGVYWLS
2050 2060 2070 2080 2090 2100
HIAQYATKNL HCEYIGLGFP SLEKVLYHRY NLVDTGLGPL SSVIRHLTNL QAEIRDLVLD
2110 2120 2130 2140 2150 2160
YNLMRESRTQ TYHFIKTAKG RITKLVNDFL KFSLIVQALK NNSSWYTELK KLPEVINVCN
2170 2180 2190 2200 2210
RFYHTHNCEC QEKFFVQTLY LQRLRDAEIK LIERLTGLMR FYPEGLIYSN HT
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Q8JPX5 in FASTA format |
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