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[1]
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NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE, AND FUNCTION.
TISSUE=Embryo;
DOI=10.1016/S0006-291X(02)00641-1; PubMed=12083771 [NCBI, ExPASy, EBI, Israel, Japan]
Satow R.,
Chan T.C.,
Asashima M.;
"Molecular cloning and characterization of dullard: a novel gene required for neural development.";
Biochem. Biophys. Res. Commun. 295:85-91(2002).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
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[3]
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FUNCTION, MUTAGENESIS OF ASP-67 AND ASP-69, INTERACTION WITH BMPR1A; BMPR1B AND BMPR2, AND SUBCELLULAR LOCATION.
DOI=10.1016/j.devcel.2006.10.001; PubMed=17141153 [NCBI, ExPASy, EBI, Israel, Japan]
Satow R.,
Kurisaki A.,
Chan T.C.,
Hamazaki T.S.,
Asashima M.;
"Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction.";
Dev. Cell 11:763-774(2006).
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- FUNCTION: Serine/threonine phosphatase which may be required for proper nuclear membrane morphology (By similarity). Induces neuronal differentiation by antagonizing BMP signaling. Acts both by dephosphorylating BMPR1A and by promoting BMPR2 proteasomal degradation.
- CATALYTIC ACTIVITY: A phosphoprotein + H2O = a protein + phosphate.
- SUBUNIT: Interacts with bmpr1a, bmpr1b and bmpr2.
- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Cytoplasm, perinuclear region.
- DEVELOPMENTAL STAGE: Expressed from egg to stage 35. Expression is restricted to the neural region as gastrulation proceeds, and is subsequently localized to neural tissues, branchial arches and pronephroi at the tail-bud stages.
- SIMILARITY: Belongs to the dullard family.
- SIMILARITY: Contains 1 FCP1 homology domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 244 AA [This is the length of the unprocessed precursor] |
Molecular weight: 28169 Da [This is the MW of the unprocessed precursor] |
CRC64: 57E95520F55D26CC [This is a checksum on the sequence] |
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10 20 30 40 50 60
MMRTPGLLGL RGFVAFAAKL WSFVLYLLRR QFRTIIQYQT VRYDVLPLSP ASRNRLSQVK
70 80 90 100 110 120
RKVLVLDLDE TLIHSHHDGV LRPTVRPGTP PDFILKVVID KHPVRFFVHK RPHVDFFLEV
130 140 150 160 170 180
VSQWYELVVF TASMEIYGSA VADKLDNNKG VLRRRFYRQH CTLELGSYIK DLSVVHSDLS
190 200 210 220 230 240
SVVILDNSPG AYRSHPDNAI PIKSWFSDPS DTALLNLLPM LDALRFTADV RSVLSRNLHQ
HRLW
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Q8JIL9 in FASTA format |
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